{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:04:20Z","timestamp":1781226260134,"version":"3.54.1"},"reference-count":46,"publisher":"Japanese Society of Toxicologic Pathology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Toxicol Pathol"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1293\/tox.2021-0058","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T22:08:58Z","timestamp":1637186938000},"page":"7-17","source":"Crossref","is-referenced-by-count":10,"title":["Luteal toxicity evaluation in rats"],"prefix":"10.1293","volume":"35","author":[{"given":"Yoshikazu","family":"Taketa","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Niigata University of              Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 950-3198,            Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"121","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1.  Sanbuissho              A,                Yoshida              M,                Hisada              S,                Sagami              F,                Kudo              S,                Kumazawa              T,                Ube              M,                Komatsu              S, and                Ohno              Y.            Collaborative work on evaluation of ovarian toxicity by repeated-dose and            fertility studies in female rats. J Toxicol Sci.            34(Suppl 1):            SP1\u2013SP22. 2009.","DOI":"10.2131\/jts.34.S1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2.  Stouffer              RL. Structure, function, and          regulation of the corpus luteum. In: Knobil and Neill\u2019s Physiology of Reproduction, 3rd          ed. JD Neill (ed). Elsevier Academic Press, San Diego. 475\u2013526.          2006.","DOI":"10.1016\/B978-012515400-0\/50017-8"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3.  Rothchild              I. The            regulation of the mammalian corpus luteum. Recent Prog Horm            Res. 37: 183\u2013298.            1981.","DOI":"10.1016\/B978-0-12-571137-1.50009-8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4.  Yoshida              M,                Sanbuissyo              A,                Hisada              S,                Takahashi              M,                Ohno              Y, and                Nishikawa              A.            Morphological characterization of the ovary under normal cycling in rats            and its viewpoints of ovarian toxicity detection. J Toxicol            Sci. 34(Suppl 1):            SP189\u2013SP197. 2009.","DOI":"10.2131\/jts.34.S189"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5.  Kaneko              S,                Sato              N,                Sato              K, and                Hashimoto              I. Changes in            plasma progesterone, estradiol, follicle-stimulating hormone and luteinizing hormone            during diestrus and ovulation in rats with 5-day estrous cycles: effect of antibody            against progesterone. Biol Reprod. 34:            488\u2013494. 1986.","DOI":"10.1095\/biolreprod34.3.488"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6.  Smith              MS,                Freeman              ME, and                Neill              JD. The control            of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat:            prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum            of pseudopregnancy. Endocrinology. 96:            219\u2013226. 1975.","DOI":"10.1210\/endo-96-1-219"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7.  Watanabe              G,                Taya              K, and                Sasamoto              S. Dynamics of            ovarian inhibin secretion during the oestrous cycle of the rat.            J Endocrinol. 126:            151\u2013157. 1990.","DOI":"10.1677\/joe.0.1260151"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8.  Espey              LL, and                Richards              JS. Ovulation. In: Knobil and          Neill\u2019s Physiology of Reproduction, 3rd ed. JD Neill (ed). Elsevier Academic Press, San          Diego. 475\u2013526. 2006.","DOI":"10.1016\/B978-012515400-0\/50016-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9.  Kim              J,                Sato              M,                Li              Q,                Lydon              JP,                Demayo              FJ,                Bagchi              IC, and                Bagchi              MK. Peroxisome            proliferator-activated receptor gamma is a target of progesterone regulation in the            preovulatory follicles and controls ovulation in mice. Mol Cell            Biol. 28: 1770\u20131782.            2008.","DOI":"10.1128\/MCB.01556-07"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10.  Hall              AP,                Ashton              S,                Horner              J,                Wilson              Z,                Reens              J,                Richmond              GHP,                Barry              ST, and                Wedge              SR. PDGFR            inhibition results in pericyte depletion and hemorrhage into the corpus luteum of the            rat ovary. Toxicol Pathol. 44:            98\u2013111. 2016.","DOI":"10.1177\/0192623315613452"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11.  Bowen              JM, and                Keyes              PL. Repeated            exposure to prolactin is required to induce luteal regression in the hypophysectomized            rat. Biol Reprod. 63:            1179\u20131184. 2000.","DOI":"10.1095\/biolreprod63.4.1179"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12.  Dixon              D,                Alison              R,                Bach              U,                Colman              K,                Foley              GL,                Harleman              JH,                Haworth              R,                Herbert              R,                Heuser              A,                Long              G,                Mirsky              M,                Regan              K,                Van Esch              E,                Westwood              FR,                Vidal              J, and                Yoshida              M.            Nonproliferative and proliferative lesions of the rat and mouse female            reproductive system. J Toxicol Pathol.            27(Suppl):            1S\u2013107S. 2014.","DOI":"10.1293\/tox.27.1S"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13.  Sato              J,                Hashimoto              S,                Doi              T,                Yamada              N, and                Tsuchitani              M. Histological            characteristics of the regression of corpora lutea in wistar hannover rats: the            comparisons with sprague-dawley rats. J Toxicol Pathol.            27: 107\u2013113. 2014.","DOI":"10.1293\/tox.2013-0054"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14.  Taketa              Y,                Inomata              A,                Hosokawa              S,                Sonoda              J,                Hayakawa              K,                Nakano              K,                Momozawa              Y,                Yamate              J,                Yoshida              M,                Aoki              T, and                Tsukidate              K.            Histopathological characteristics of luteal hypertrophy induced by            ethylene glycol monomethyl ether with a comparison to normal luteal morphology in            rats. Toxicol Pathol. 39:            372\u2013380. 2011.","DOI":"10.1177\/0192623310388429"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15.  T\u00e9bar              M,                Ruiz              A,                Gayt\u00e1n              F, and                S\u00e1nchez-Criado              JE. Follicular            and luteal progesterone play different roles synchronizing pituitary and ovarian events            in the 4-day cyclic rat. Biol Reprod.            53: 1183\u20131189. 1995.","DOI":"10.1095\/biolreprod53.5.1183"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16.  Bruot              BC,                Wiest              WG, and                Collins              DC. Effect of            low density and high density lipoproteins on progesterone secretion by dispersed corpora            luteal cells from rats treated with aminopyrazolo-(3,4-d)pyrimidine.            Endocrinology. 110:            1572\u20131578. 1982.","DOI":"10.1210\/endo-110-5-1572"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17.  Schuler              LA,                Langenberg              KK,                Gwynne              JT, and                Strauss                  JF 3rd.           High density lipoprotein utilization by dispersed rat            luteal cells. Biochim Biophys Acta.            664: 583\u2013601. 1981.","DOI":"10.1016\/0005-2760(81)90135-1"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18.  Acton              S,                Rigotti              A,                Landschulz              KT,                Xu              S,                Hobbs              HH, and                Krieger              M.            Identification of scavenger receptor SR-BI as a high density lipoprotein            receptor. Science. 271:            518\u2013520. 1996.","DOI":"10.1126\/science.271.5248.518"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19.  Stocco              DM. StAR            protein and the regulation of steroid hormone biosynthesis. Annu            Rev Physiol. 63: 193\u2013213.            2001.","DOI":"10.1146\/annurev.physiol.63.1.193"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20.  Oonk              RB,                Krasnow              JS,                Beattie              WG, and                Richards              JS. Cyclic            AMP-dependent and -independent regulation of cholesterol side chain cleavage cytochrome            P-450 (P-450scc) in rat ovarian granulosa cells and corpora lutea. cDNA and deduced            amino acid sequence of rat P-450scc. J Biol Chem.            264: 21934\u201321942. 1989.","DOI":"10.1016\/S0021-9258(20)88275-1"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21.  Peng              L,                Arensburg              J,                Orly              J, and                Payne              AH. The murine            3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene family: a postulated role for            3beta-HSD VI during early pregnancy. Mol Cell            Endocrinol. 187: 213\u2013221.            2002.","DOI":"10.1016\/S0303-7207(01)00689-X"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22.  Stocco              CO,                Zhong              L,                Sugimoto              Y,                Ichikawa              A,                Lau              LF, and                Gibori              G.            Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid            dehydrogenase involves the transcription factor NUR77. J Biol            Chem. 275: 37202\u201337211.            2000.","DOI":"10.1074\/jbc.M006016200"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23.  Taketa              Y,                Yoshida              M,                Inoue              K,                Takahashi              M,                Sakamoto              Y,                Watanabe              G,                Taya              K,                Yamate              J, and                Nishikawa              A. The newly            formed corpora lutea of normal cycling rats exhibit drastic changes in steroidogenic and            luteolytic gene expressions. Exp Toxicol Pathol.            64: 775\u2013782. 2012.","DOI":"10.1016\/j.etp.2011.01.015"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24.  Stocco              C,                Telleria              C, and                Gibori              G. The            molecular control of corpus luteum formation, function, and regression.            Endocr Rev. 28: 117\u2013149.            2007.","DOI":"10.1210\/er.2006-0022"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25.  Pharriss              BB, and                Wyngarden              LJ. The effect            of prostaglandin F 2alpha on the progestogen content of ovaries from pseudopregnant            rats. Proc Soc Exp Biol Med. 130:            92\u201394. 1969.","DOI":"10.3181\/00379727-130-33495"},{"key":"26","unstructured":"26.  Plas-Roser              S,                Muller              B, and                Aron              C. Estradiol            involvement in the luteolytic action of LH during the estrous cycle in the            rat. Exp Clin Endocrinol. 92:            145\u2013153. 1988."},{"key":"27","doi-asserted-by":"publisher","unstructured":"27.  Stocco              C,                Callegari              E, and                Gibori              G. Opposite            effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as            revealed by rat cDNA expression array. Endocrinology.            142: 4158\u20134161. 2001.","DOI":"10.1210\/en.142.9.4158"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28.  Gayt\u00e1n              F,                Morales              C,                Bellido              C,                Aguilar              R,                Mill\u00e1n              Y,                Mart\u00edn De Las Mulas              J, and                S\u00e1nchez-Criado              JE.            Progesterone on an oestrogen background enhances prolactin-induced            apoptosis in regressing corpora lutea in the cyclic rat: possible involvement of luteal            endothelial cell progesterone receptors. J Endocrinol.            165: 715\u2013724. 2000.","DOI":"10.1677\/joe.0.1650715"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29.  Roughton              SA,                Lareu              RR,                Bittles              AH, and                Dharmarajan              AM. Fas and Fas            ligand messenger ribonucleic acid and protein expression in the rat corpus luteum during            apoptosis-mediated luteolysis. Biol Reprod.            60: 797\u2013804. 1999.","DOI":"10.1095\/biolreprod60.4.797"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30.  Yadav              VK,                Lakshmi              G, and                Medhamurthy              R.            Prostaglandin F2alpha-mediated activation of apoptotic signaling cascades            in the corpus luteum during apoptosis: involvement of caspase-activated            DNase. J Biol Chem. 280:            10357\u201310367. 2005.","DOI":"10.1074\/jbc.M409596200"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31.  Vidal              JD. The impact            of age on the female reproductive system: a pathologist\u2019s perspective.            Toxicol Pathol. 45:            206\u2013215. 2017.","DOI":"10.1177\/0192623316673754"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32.  Patyna              S,                Arrigoni              C,                Terron              A,                Kim              TW,                Heward              JK,                Vonderfecht              SL,                Denlinger              R,                Turnquist              SE, and                Evering              W. Nonclinical            safety evaluation of sunitinib: a potent inhibitor of VEGF, PDGF, KIT, FLT3, and RET            receptors. Toxicol Pathol. 36:            905\u2013916. 2008.","DOI":"10.1177\/0192623308326151"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33.  Chapin              RE,                Gulati              DK,                Barnes              LH, and                Teague              JL. The effects            of feed restriction on reproductive function in Sprague-Dawley rats.            Fundam Appl Toxicol. 20:            23\u201329. 1993.","DOI":"10.1093\/toxsci\/20.1.23"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34.  Hayashi              S,                Taketa              Y,                Inoue              K,                Takahashi              M,                Matsuo              S,                Irie              K,                Watanabe              G, and                Yoshida              M. Effects of            pyperonyl butoxide on the female reproductive tract in rats. J            Toxicol Sci. 38: 891\u2013902.            2013.","DOI":"10.2131\/jts.38.891"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35.  Taketa              Y,                Yoshida              M,                Inoue              K,                Takahashi              M,                Sakamoto              Y,                Watanabe              G,                Taya              K,                Yamate              J, and                Nishikawa              A. Differential            stimulation pathways of progesterone secretion from newly formed corpora lutea in rats            treated with ethylene glycol monomethyl ether, sulpiride, or atrazine.            Toxicol Sci. 121:            267\u2013278. 2011.","DOI":"10.1093\/toxsci\/kfr062"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36.  Davis              BJ,                Almekinder              JL,                Flagler              N,                Travlos              G,                Wilson              R, and                Maronpot              RR. Ovarian            luteal cell toxicity of ethylene glycol monomethyl ether and methoxy acetic acid in vivo            and in vitro. Toxicol Appl Pharmacol.            142: 328\u2013337. 1997.","DOI":"10.1006\/taap.1996.8035"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37.  Almekinder              JL,                Lennard              DE,                Walmer              DK, and                Davis              BJ. Toxicity of            methoxyacetic acid in cultured human luteal cells. Fundam Appl            Toxicol. 38: 191\u2013194.            1997.","DOI":"10.1093\/toxsci\/38.2.191"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38.  Taketa              Y,                Inoue              K,                Takahashi              M,                Yamate              J, and                Yoshida              M. Differential            morphological effects in rat corpora lutea among ethylene glycol monomethyl ether,            atrazine, and bromocriptine. Toxicol Pathol.            41: 736\u2013743. 2013.","DOI":"10.1177\/0192623312464305"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39.  Cooper              RL,                Laws              SC,                Das              PC,                Narotsky              MG,                Goldman              JM,                Lee Tyrey              E, and                Stoker              TE. Atrazine            and reproductive function: mode and mechanism of action studies.            Birth Defects Res B Dev Reprod Toxicol. 80:            98\u2013112. 2007.","DOI":"10.1002\/bdrb.20110"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40.  Rehm              S,                Stanislaus              DJ, and                Wier              PJ.            Identification of drug-induced hyper- or hypoprolactinemia in the female            rat based on general and reproductive toxicity study parameters.            Birth Defects Res B Dev Reprod Toxicol. 80:            253\u2013257. 2007.","DOI":"10.1002\/bdrb.20126"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41.  Comereski              CR,                Peden              WM,                Davidson              TJ,                Warner              GL,                Hirth              RS, and                Frantz              JD.            BR96-doxorubicin conjugate (BMS-182248) versus doxorubicin: a comparative            toxicity assessment in rats. Toxicol Pathol.            22: 473\u2013488. 1994.","DOI":"10.1177\/019262339402200502"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42.  Tamura              T,                Yokoi              R,                Okuhara              Y,                Harada              C,                Terashima              Y,                Hayashi              M,                Nagasawa              T,                Onozato              T,                Kobayashi              K,                Kuroda              J, and                Kusama              H.            Collaborative work on evaluation of ovarian toxicity. 2) Two- or            four-week repeated dose studies and fertility study of mifepristone in female            rats. J Toxicol Sci.            34(Suppl 1):            SP31\u2013SP42. 2009.","DOI":"10.2131\/jts.34.S31"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43.  Tsubota              K,                Kushima              K,                Yamauchi              K,                Matsuo              S,                Saegusa              T,                Ito              S,                Fujiwara              M,                Matsumoto              M,                Nakatsuji              S,                Seki              J, and                Oishi              Y.            Collaborative work on evaluation of ovarian toxicity. 12) Effects of 2-            or 4-week repeated dose studies and fertility study of indomethacin in female            rats. J Toxicol Sci.            34(Suppl 1):            SP129\u2013SP136. 2009.","DOI":"10.2131\/jts.34.S129"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44.  Sato              N,                Uchida              K,                Nakajima              M,                Watanabe              A, and                Kohira              T.            Collaborative work on evaluation of ovarian toxicity. 13) Two- or            four-week repeated dose studies and fertility study of PPAR alpha\/gamma dual agonist in            female rats. J Toxicol Sci.            34(Suppl 1):            SP137\u2013SP146. 2009.","DOI":"10.2131\/jts.34.S137"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45.  Kumazawa              T,                Nakajima              A,                Ishiguro              T,                Jiuxin              Z,                Tanaharu              T,                Nishitani              H,                Inoue              Y,                Harada              S,                Hayasaka              I, and                Tagawa              Y.            Collaborative work on evaluation of ovarian toxicity. 15) Two- or            four-week repeated-dose studies and fertility study of bromocriptine in female            rats. J Toxicol Sci.            34(Suppl 1):            SP157\u2013SP165. 2009.","DOI":"10.2131\/jts.34.S157"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46.  L\u00f6seke              A, and                Spanel-Borowski              K. Simple or            repeated induction of superovulation: a study on ovulation rates and microvessel            corrosion casts in ovaries of golden hamsters. Ann          Anat. 178: 5\u201314.          1996.","DOI":"10.1016\/S0940-9602(96)80003-3"}],"container-title":["Journal of Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tox\/35\/1\/35_2021-0058\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T04:23:10Z","timestamp":1643430190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/tox\/35\/1\/35_2021-0058\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1293\/tox.2021-0058","relation":{},"ISSN":["0914-9198","1881-915X"],"issn-type":[{"value":"0914-9198","type":"print"},{"value":"1881-915X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"2021-0058"}}