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ICH S8 guideline: Immunotoxicity studies for human pharmaceuticals. 2005. http:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Safety\/S8\/Step4\/S8_Guideline.pdf."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Luster MI, Dean JH, and Boorman GA. Cell-mediated immunity and its application in toxicology.Environ Health Perspect.<b>43<\/b>: 31-36. 1982.","DOI":"10.1289\/ehp.824331"},{"key":"3","unstructured":"3. Descotes J, Tedone R, and Evreux JC. Immunotoxicity screening of drugs and chemicals: value of contact hypersensitivity to picryl chloride in the mouse.Methods Find Exp Clin Pharmacol.<b>7:<\/b>303-305. 1985."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dietert RR, Bunn TL, and Lee JE. The delayed type hypersensitivity assay using protein and xenogeneic cell antigens.Methods Mol Biol.<b>598:<\/b>185-194. 2010.","DOI":"10.1007\/978-1-60761-401-2_13"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Smith MJ, and White KLJrEstablishment and comparison of delayed-type hypersensitivity models in the B6C3F1 mouse.J Immunotoxicol.<b>7<\/b>: 308-317. 2010.","DOI":"10.3109\/1547691X.2010.509707"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Bussiere JL. Species selection considerations for preclinical toxicology studies for biotherapeutics.Expert Opin Drug Metab Toxicol.<b>4<\/b>: 871-877. 2008.","DOI":"10.1517\/17425255.4.7.871"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Bleavins MR, and de la Iglesia FA. Cynomolgus monkeys (<i>Macaca fascicularis<\/i>) in preclinical immune function safety testing: development of a delayed-type hypersensitivity procedure.Toxicology.<b>95<\/b>: 103-112. 1995.","DOI":"10.1016\/0300-483X(95)90402-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. C &oacute;rdoba F, Wieczorek G, Preussing E, and Bigaud M.Modeling of delayed type hypersensitivity (DTH) in the non-human primate (NHP).Drug Discov Today Anim Models.<b>5:<\/b>63-71. 2008.","DOI":"10.1016\/j.ddmod.2008.05.002"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Price K. Cellular immune response in delayed-type hypersensitivity tests. In: Immunotoxicology Strategies for Pharmaceutical Safety Assessment. DJ Herzyk, and JL Bussiere (eds). Wiley, New York. 87-103. 2008.","DOI":"10.1002\/9780470386385.ch8"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Palestine AG, Roberge F, Charous BL, Lane HC, Fauci AS, and Nussenblatt RB. The effect of cyclosporine on immunization with tetanus and keyhole limpet hemocyanin (KLH) in humans.J Clin Immunol.<b>5:<\/b>115-121. 1985.","DOI":"10.1007\/BF00915009"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. French AL, McCullough ME, Rice KT, Schultz ME, and Gordin FM. 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Vocanson M, Hennino A, Chavagnac C, Saint-Mezard P, Dubois B, Kaiserlian D, and Nicolas JF. Contribution of CD4<sup>+<\/sup> and CD8<sup>+<\/sup> T-cells in contact hypersensitivity and allergic contact dermatitis.Expert Rev Clin Immunol.<b>1:<\/b>75-86. 2005.","DOI":"10.1586\/1744666X.1.1.75"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Luster MI, Portier C, Pait DG, White KLJr, Gennings C, Munson AE, and Rosenthal GJ. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests.Fundam Appl Toxicol.<b>18<\/b>: 200-210. 1992.","DOI":"10.1016\/0272-0590(92)90047-L"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Galant SP, Flod N, Shimizu I, Granger GA, and Groncy CE. 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