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Taubenberger JK, Morens DM. 2010. Influenza: the once and future pandemic. Public Health Rep 125 Suppl 3: 16\u201326.","DOI":"10.1177\/00333549101250S305"},{"key":"2","unstructured":"2. McCaughey C. 2010. Influenza: a virus of our times. Ulster Med J 79: 46\u201351."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Van Reeth K, Nauwynck H, Pensaert M. 1998. Bronchoalveolar interferon-alpha, tumor necrosis factor-alpha, interleukin-1, and inflammation during acute influenza in pigs: a possible model for humans? J Infect Dis 177: 1076\u20131079.","DOI":"10.1086\/517398"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Julkunen I, Sareneva T, Pirhonen J, Ronni T, Mel\u00e9n K, Matikainen S. 2001. Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev 12: 171\u2013180.","DOI":"10.1016\/S1359-6101(00)00026-5"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kaiser L, Fritz RS, Straus SE, Gubareva L, Hayden FG. 2001. Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses. J Med Virol 64: 262\u2013268.","DOI":"10.1002\/jmv.1045"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Mok KP, Wong CHK, Cheung CY, Chan MC, Lee SMY, Nicholls JM, Guan Y, Peiris JSM. 2009. Viral genetic determinants of H5N1 influenza viruses that contribute to cytokine dysregulation. J Infect Dis 200: 1104\u20131112.","DOI":"10.1086\/605606"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Boyd M, Clezy K, Lindley R, Pearce R. 2006. Pandemic influenza: clinical issues. Med J Aust 185 Suppl: S44\u2013S47.","DOI":"10.5694\/j.1326-5377.2006.tb00706.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lynch JP 3rd, Walsh EE. 2007. Influenza: evolving strategies in treatment and prevention. Semin Respir Crit Care Med 28: 144\u2013158.","DOI":"10.1055\/s-2007-976487"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Tsai YT, Cheng PC, Pan TM. 2012. The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits. Appl Microbiol Biotechnol 96: 853\u2013862.","DOI":"10.1007\/s00253-012-4407-3"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Vinderola G, Perdig\u00f3n G, Duarte J, Farnworth E, Matar C. 2006. Effects of the oral administration of the exopolysaccharide produced by <i>Lactobacillus kefiranofaciens<\/i> on the gut mucosal immunity. Cytokine 36: 254\u2013260.","DOI":"10.1016\/j.cyto.2007.01.003"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Nakayama Y, Moriya T, Sakai F, Ikeda N, Shiozaki T, Hosoya T, Nakagawa H, Miyazaki T. 2014. Oral administration of <i>Lactobacillus gasseri<\/i> SBT2055 is effective for preventing influenza in mice. Sci Rep 4: 4638.","DOI":"10.1038\/srep04638"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Asama T, Arima TH, Gomi T, Keishi T, Tani H, Kimura Y, Tatefuji T, Hashimoto K. 2015. <i>Lactobacillus kunkeei<\/i> YB38 from honeybee products enhances IgA production in healthy adults. J Appl Microbiol 119: 818\u2013826.","DOI":"10.1111\/jam.12889"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Fagarasan S, Honjo T. 2003. Intestinal IgA synthesis: regulation of front-line body defences. Nat Rev Immunol 3: 63\u201372.","DOI":"10.1038\/nri982"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Shvartsman YS, Zykov MP. 1976. Secretory anti-influenza immunity. Adv Immunol 22: 291\u2013330.","DOI":"10.1016\/S0065-2776(08)60551-9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kobayashi N, Saito T, Uematsu T, Kishi K, Toba M, Kohda N, Suzuki T. 2011. Oral administration of heat-killed <i>Lactobacillus pentosus<\/i> strain b240 augments protection against influenza virus infection in mice. Int Immunopharmacol 11: 199\u2013203.","DOI":"10.1016\/j.intimp.2010.11.019"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Seki M, Yanagihara K, Higashiyama Y, Fukuda Y, Kaneko Y, Ohno H, Miyazaki Y, Hirakata Y, Tomono K, Kadota J, Tashiro T, Kohno S. 2004. Immunokinetics in severe pneumonia due to influenza virus and bacteria coinfection in mice. Eur Respir J 24: 143\u2013149.","DOI":"10.1183\/09031936.04.00126103"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Seki M, Kohno S, Newstead MW, Zeng X, Bhan U, Lukacs NW, Kunkel SL, Standiford TJ. 2010. Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia. J Immunol 184: 1410\u20131418.","DOI":"10.4049\/jimmunol.0901709"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Uematsu T, Iizasa E, Kobayashi N, Yoshida H, Hara H. 2015. Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity. Sci Rep 5: 17577.","DOI":"10.1038\/srep17577"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Hoffmann E, Stech J, Guan Y, Webster RG, Perez DR. 2001. Universal primer set for the full-length amplification of all influenza A viruses. Arch Virol 146: 2275\u20132289.","DOI":"10.1007\/s007050170002"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S. 2007. Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. J Immunol 179: 4711\u20134720.","DOI":"10.4049\/jimmunol.179.7.4711"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y, Kim JH, Halfmann P, Hatta M, Feldmann F, Alimonti JB, Fernando L, Li Y, Katze MG, Feldmann H, Kawaoka Y. 2007. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445: 319\u2013323.","DOI":"10.1038\/nature05495"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Cill\u00f3niz C, Shinya K, Peng X, Korth MJ, Proll SC, Aicher LD, Carter VS, Chang JH, Kobasa D, Feldmann F, Strong JE, Feldmann H, Kawaoka Y, Katze MG. 2009. Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathog 5: e1000604.","DOI":"10.1371\/journal.ppat.1000604"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Suzuki T, Kawaguchi A, Ainai A, Tamura S, Ito R, Multihartina P, Setiawaty V, Pangesti KNA, Odagiri T, Tashiro M, Hasegawa H. 2015. Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus. Proc Natl Acad Sci USA 112: 7809\u20137814.","DOI":"10.1073\/pnas.1503885112"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kikuchi Y, Kunitoh-Asari A, Hayakawa K, Imai S, Kasuya K, Abe K, Adachi Y, Fukudome S, Takahashi Y, Hachimura S. 2014. Oral administration of <i>Lactobacillus plantarum<\/i> strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice. PLoS One 9: e86416.","DOI":"10.1371\/journal.pone.0086416"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Brandtzaeg P. 1995. The role of humoral mucosal immunity in the induction and maintenance of chronic airway infections. Am J Respir Crit Care Med 151: 2081\u20132086, discussion 2086\u20132087.","DOI":"10.1164\/ajrccm.151.6.7767561"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Sonoda E, Matsumoto R, Hitoshi Y, Ishii T, Sugimoto M, Araki S, Tominaga A, Yamaguchi N, Takatsu K. 1989. Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production. J Exp Med 170: 1415\u20131420.","DOI":"10.1084\/jem.170.4.1415"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Coffman RL, Lebman DA, Shrader B. 1989. Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J Exp Med 170: 1039\u20131044.","DOI":"10.1084\/jem.170.3.1039"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Kim PH, Kagnoff MF. 1990. Transforming growth factor-beta 1 is a costimulator for IgA production. J Immunol 144: 3411\u20133416.","DOI":"10.4049\/jimmunol.144.9.3411"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. He B, Xu W, Santini PA, Polydorides AD, Chiu A, Estrella J, Shan M, Chadburn A, Villanacci V, Plebani A, Knowles DM, Rescigno M, Cerutti A. 2007. Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity 26: 812\u2013826.","DOI":"10.1016\/j.immuni.2007.04.014"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Xu W, He B, Chiu A, Chadburn A, Shan M, Buldys M, Ding A, Knowles DM, Santini PA, Cerutti A. 2007. Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nat Immunol 8: 294\u2013303.","DOI":"10.1038\/ni1434"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Castigli E, Wilson SA, Scott S, Dedeoglu F, Xu S, Lam KP, Bram RJ, Jabara H, Geha RS. 2005. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med 201: 35\u201339.","DOI":"10.1084\/jem.20032000"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. Mora JR, Iwata M, Eksteen B, Song SY, Junt T, Senman B, Otipoby KL, Yokota A, Takeuchi H, Ricciardi-Castagnoli P, Rajewsky K, Adams DH, von Andrian UH. 2006. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 314: 1157\u20131160.","DOI":"10.1126\/science.1132742"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Mora JR, von Andrian UH. 2008. Differentiation and homing of IgA-secreting cells. Mucosal Immunol 1: 96\u2013109.","DOI":"10.1038\/mi.2007.14"},{"key":"34","doi-asserted-by":"publisher","unstructured":"34. Tezuka H, Abe Y, Iwata M, Takeuchi H, Ishikawa H, Matsushita M, Shiohara T, Akira S, Ohteki T. 2007. Regulation of IgA production by naturally occurring TNF\/iNOS-producing dendritic cells. 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