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Daimon              T, Kiuchi              T, Takasu              Y. 2014.            Recent progress in genome engineering techniques in the silkworm,              <i>Bombyx mori<\/i>. Dev Growth            Differ 56: 14\u201325.","DOI":"10.1111\/dgd.12096"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Goldsmith              MR, Shimada              T, Abe              H. 2005.            The genetics and genomics of the silkworm, <i>Bombyx            mori<\/i>. Annu Rev Entomol 50:            71\u2013100.","DOI":"10.1146\/annurev.ento.50.071803.130456"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Itoh              K, Kobayashi              I, Nishioka              S, Sezutsu              H, Machii              H, Tamura              T. 2016.            Recent progress in development of transgenic silkworms overexpressing            recombinant human proteins with therapeutic potential in silk glands.            Drug Discov Ther 10:            34\u201339.","DOI":"10.5582\/ddt.2016.01024"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Tomita              M, Munetsuna              H, Sato              T, Adachi              T, Hino              R, Hayashi              M, Shimizu              K, Nakamura              N, Tamura              T, Yoshizato              K. 2003.            Transgenic silkworms produce recombinant human type III procollagen in            cocoons. Nat Biotechnol 21:            52\u201356.","DOI":"10.1038\/nbt771"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Tomita              M. 2011.            Transgenic silkworms that weave recombinant proteins into silk            cocoons. Biotechnol Lett 33:            645\u2013654.","DOI":"10.1007\/s10529-010-0498-z"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kato              T, Kajikawa              M, Maenaka              K, Park              EY. 2010.            Silkworm expression system as a platform technology in life            science. Appl Microbiol Biotechnol 85:            459\u2013470.","DOI":"10.1007\/s00253-009-2267-2"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Marzoli              F, Antonelli              P, Saviane              A, Tassoni              L,                Cappellozza              S, Belluco              S. 2022.              <i>Bombyx mori<\/i> from a food safety perspective: a            systematic review. Food Res Int 160:            111679.","DOI":"10.1016\/j.foodres.2022.111679"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hayes              BJ, Lewin              HA, Goddard              ME. 2013.            The future of livestock breeding: genomic selection for efficiency,            reduced emissions intensity, and adaptation. Trends            Genet 29: 206\u2013214.","DOI":"10.1016\/j.tig.2012.11.009"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Park              SJ, Kim              KY, Baik              MY, Koh              YH. 2022.            Sericulture and the edible-insect industry can help humanity survive:            insects are more than just bugs, food, or feed. Food Sci            Biotechnol 31: 657\u2013668.","DOI":"10.1007\/s10068-022-01090-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ros-Bar\u00f3              M,                Casas-Agustench              P,                D\u00edaz-Rizzolo              DA,                Batlle-Bayer              L,                Adri\u00e0-Acosta              F,                Aguilar-Mart\u00ednez              A, Medina              FX, Pujol\u00e0              M, Bach-Faig              A. 2022.            Edible insect consumption for human and planetary health: a systematic            review. Int J Environ Res Public Health 19: 11653.","DOI":"10.3390\/ijerph191811653"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Osimani              A, Garofalo              C, Milanovi\u0107              V, Taccari              M, Cardinali              F, Aquilanti              L, Pasquini              M, Mozzon              M, Raffaelli              N, Ruschioni              S, et            al. 2017. Insight into the proximate            composition and microbial diversity of edible insects marketed in the European            Union. Eur Food Res Technol 243:            1157\u20131171.","DOI":"10.1007\/s00217-016-2828-4"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Zhang              YQ. 2002.            Applications of natural silk protein sericin in            biomaterials. Biotechnol Adv 20:            91\u2013100.","DOI":"10.1016\/S0734-9750(02)00003-4"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Sultan              MT, Hong              H, Lee              OJ, Ajiteru              O, Lee              YJ, Lee              JS, Lee              H, Kim              SH, Park              CH. 2022.            Silk fibroin-based biomaterials for hemostatic            applications. Biomolecules 12:            660.","DOI":"10.3390\/biom12050660"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Gupta              D, Agrawal              A, Chaudhary              H, Gulrajani              M, Gupta              C. 2013.            Cleaner process for extraction of sericin using infrared.            J Clean Prod 52:          488\u2013494.","DOI":"10.1016\/j.jclepro.2013.03.016"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Aramwit              P,                Siritientong              T, Srichana              T. 2012.            Potential applications of silk sericin, a natural protein from textile            industry by-products. Waste Manag Res 30: 217\u2013224.","DOI":"10.1177\/0734242X11404733"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kundu              SC, Dash              BC, Dash              R, Kaplan              DL. 2008.            Natural protective glue protein, sericin bioengineered by silkworms:            potential for biomedical and biotechnological applications. Prog            Polym Sci 33: 998\u20131012.","DOI":"10.1016\/j.progpolymsci.2008.08.002"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sasaki              M, Kato              Y, Yamada              H, Terada              S. 2005.            Development of a novel serum-free freezing medium for mammalian cells            using the silk protein sericin. Biotechnol Appl            Biochem 42: 183\u2013188.","DOI":"10.1042\/BA20050019"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Terada              S, Nishimura              T, Sasaki              M, Yamada              H, Miki              M. 2002.            Sericin, a protein derived from silkworms, accelerates the proliferation            of several mammalian cell lines including a hybridoma.            Cytotechnology 40: 3\u201312.","DOI":"10.1023\/A:1023993400608"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kato              N, Iwami              K. 2002.            Resistant protein; its existence and function beneficial to            health. J Nutr Sci Vitaminol (Tokyo) 48: 1\u20135.","DOI":"10.3177\/jnsv.48.1"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sasaki              M, Yamada              H, Kato              N. 2000.            A resistant protein, sericin improves atropine-induced constipation in            rats. Food Sci Technol Res 6:            280\u2013283.","DOI":"10.3136\/fstr.6.280"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Okazaki              Y, Tomotake              H, Tsujimoto              K, Sasaki              M, Kato              N. 2011.            Consumption of a resistant protein, sericin, elevates fecal            immunoglobulin A, mucins, and cecal organic acids in rats fed a high-fat            diet. J Nutr 141:            1975\u20131981.","DOI":"10.3945\/jn.111.144246"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chouhan              D, Mandal              BB. 2020.            Silk biomaterials in wound healing and skin regeneration therapeutics:            from bench to bedside. Acta Biomater 103: 24\u201351.","DOI":"10.1016\/j.actbio.2019.11.050"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Rodriguez-Nogales              A,                Lozano-P\u00e9rez              AA,                Aznar-Cervantes              SD, Algieri              F,                Garrido-Mesa              J,                Garrido-Mesa              N, Vezza              T, Utrilla              MP, Cenis              JL,                Rodr\u00edguez-Cabezas              ME, et            al. 2016. Effect of aqueous and            particulate silk fibroin in a rat model of experimental colitis.            Int J Pharm 511: 1\u20139.","DOI":"10.1016\/j.ijpharm.2016.06.120"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Adolfsson              O, Meydani              SN, Russell              RM. 2004.            Yogurt and gut function. Am J Clin            Nutr 80: 245\u2013256.","DOI":"10.1093\/ajcn\/80.2.245"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Sanders              ME. 2008.            Probiotics: definition, sources, selection, and uses.            Clin Infect Dis 46 Suppl 2:          S58\u2013S61, discussion S144\u2013S151.","DOI":"10.1086\/523341"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Cotter              PD, Ross              RP, Hill              C. 2013.            Bacteriocins\u2014a viable alternative to            antibiotics? Nat Rev Microbiol 11:            95\u2013105.","DOI":"10.1038\/nrmicro2937"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Liu              W, Pang              H, Zhang              H, Cai              Y. 2014.          Biodiversity of lactic acid bacteria. <i>In<\/i> Bacteria Fundamentals and          Practice, Zhang H, Cai Y (eds), Springer, Heidelberg, pp. 103\u2013203.","DOI":"10.1007\/978-94-017-8841-0_2"},{"key":"28","unstructured":"28. Sugiyama              M, Noda              M. 2011.            Health science of plant-derived lactic acid bacteria.            New Food Industry 53:            7\u201314."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Higashikawa              F, Noda              M, Awaya              T,                Danshiitsoodol              N, Matoba              Y, Kumagai              T, Sugiyama              M. 2016.            Antiobesity effect of <i>Pediococcus pentosaceus<\/i> LP28 on            overweight subjects: a randomized, double-blind, placebo-controlled clinical            trial. Eur J Clin Nutr 70:            582\u2013587.","DOI":"10.1038\/ejcn.2016.17"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. Noda              M, Kanno              K,                Danshiitsoodol              N,                Higashikawa              F, Sugiyama              M. 2021.            Plant-derived <i>Lactobacillus paracasei<\/i> IJH-SONE68            improves chronic allergy status: a randomized, double-blind, placebo-controlled clinical            trial. Nutrients 13:            4022.","DOI":"10.3390\/nu13114022"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Fei              W, Noda              M,                Danshiitsoodol              N, Sugiyama              M. 2024.            Skin anti-aging efficacy of a <i>Lactobacillus plantarum<\/i>            GT-17F fermented <i>Dendrobium officinale<\/i> ingredient: a randomized,            double-blind, placebo-controlled clinical study.            Cosmetics 11: 26.","DOI":"10.3390\/cosmetics11010026"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. Higashikawa              F, Noda              M, Awaya              T, Nomura              K, Oku              H, Sugiyama              M. 2010.            Improvement of constipation and liver function by plant-derived lactic            acid bacteria: a double-blind, randomized trial.            Nutrition 26: 367\u2013374.","DOI":"10.1016\/j.nut.2009.05.008"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Higashikawa              F,                Danshiitsoodol              N, Kanno              K, Ishida              R, Tazuma              S, Sugiyama              M. 2020.              <i>Lactobacillus plantarum<\/i> SN13T cells improve hepatic            dysfunction and fecal microbiota: a randomized pilot study. Arch            Clin Biomed Res 4: 605\u2013625.","DOI":"10.26502\/acbr.50170129"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Noda              M, Sugimoto              S, Hayashi              I,                Danshiitsoodol              N, Fukamachi              M, Sugiyama              M. 2018.            A novel structure of exopolysaccharide produced by a plant-derived lactic            acid bacterium <i>Lactobacillus paracasei<\/i> IJH-SONE68.            J Biochem 164: 87\u201392.","DOI":"10.1093\/jb\/mvy048"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Hiraishi              A. 1992.            Direct automated sequencing of 16S rDNA amplified by polymerase chain            reaction from bacterial cultures without DNA purification. Lett            Appl Microbiol 15: 210\u2013213.","DOI":"10.1111\/j.1472-765X.1992.tb00765.x"},{"key":"36","unstructured":"36. Lane              DJ. 1991. 16S\/23S          rRNA sequencing. <i>In<\/i> Nucleic Acid Techniques in Bacterial Systematics,          Stackebrandt E, Goodfellow M (eds), John Wiley and Sons, Chichester, pp.          115\u2013175."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Weisburg              WG, Barns              SM, Pelletier              DA, Lane              DJ. 1991.            16S ribosomal DNA amplification for phylogenetic study.            J Bacteriol 173:          697\u2013703.","DOI":"10.1128\/jb.173.2.697-703.1991"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Altschul              SF, Gish              W, Miller              W, Myers              EW, Lipman              DJ. 1990.            Basic local alignment search tool. J Mol            Biol 215: 403\u2013410.","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Oda              Y, Funasaka              K, Kitano              M, Nakama              A, Yoshikura              T. 2004.            Use of a high-throughput <i>umu<\/i>-microplate test system for            rapid detection of genotoxicity produced by mutagenic carcinogens and airborne            particulate matter. Environ Mol Mutagen 43: 10\u201319.","DOI":"10.1002\/em.10209"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Sakura              A, Suzuki              S, Satoh              T. 2004.          Improvement of the Ames test using human liver S9 preparation. <i>In<\/i>          Optimization in Drug Discovery: In Vitro Methods. Methods in Pharmacology and Toxicology,          Yan Z, Caldwell G (eds), Humana Press, Totowa, pp. 325\u2013336.","DOI":"10.1385\/1-59259-800-5:325"},{"key":"41","unstructured":"41. Iida              N, Tsurui              Y, Tsuneyama              I. 2018.            Breeding of a new silkworm race named as \u2018Ryokken 2 gou\u2019 for obtaining            flavonoid-rich cocoons. J Dainippon Silk            Foundation 65:          9\u201315."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Lewis              SJ, Heaton              KW. 1997.            Stool form scale as a useful guide to intestinal transit            time. Scand J Gastroenterol 32:            920\u2013924.","DOI":"10.3109\/00365529709011203"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Riegler              G, Esposito              I. 2001.            Bristol scale stool form. A still valid help in medical practice and            clinical research. Tech Coloproctol 5:            163\u2013164.","DOI":"10.1007\/s101510100019"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Ellis              KJ. 2000.            Human body composition: in vivo methods. Physiol            Rev 80: 649\u2013680.","DOI":"10.1152\/physrev.2000.80.2.649"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Umemura              S, Arima              H, Arima              S, Asayama              K, Dohi              Y, Hirooka              Y, Horio              T, Hoshide              S, Ikeda              S, Ishimitsu              T, et            al. 2019. The Japanese Society of            Hypertension Guidelines for the Management of Hypertension (JSH 2019).            Hypertens Res 42:            1235\u20131481.","DOI":"10.1038\/s41440-019-0284-9"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Morita              H, Kuwahara              T, Ohshima              K, Sasamoto              H, Itoh              K, Hattori              M, Hayashi              Y, Takami              H. 2007.            An improved DNA isolation method for metagenomic analysis of the            microbial flora of the human intestine. Microbes            Environ 22: 214\u2013222.","DOI":"10.1264\/jsme2.22.214"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Kim              SW, Suda              W, Kim              S, Oshima              K, Fukuda              S, Ohno              H, Morita              H, Hattori              M. 2013.            Robustness of gut microbiota of healthy adults in response to probiotic            intervention revealed by high-throughput pyrosequencing. DNA            Res 20: 241\u2013253.","DOI":"10.1093\/dnares\/dst006"},{"key":"48","doi-asserted-by":"publisher","unstructured":"48. Danshiitsoodol              N, Noda              M, Kanno              K, Uchida              T, Sugiyama              M. 2022.            Plant-derived <i>Lactobacillus paracasei<\/i> IJH-SONE68            improves the gut microbiota associated with hepatic disorders: a randomized,            double-blind, and placebo-controlled clinical trial.            Nutrients 14: 4492.","DOI":"10.3390\/nu14214492"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Caporaso              JG, Kuczynski              J, Stombaugh              J, Bittinger              K, Bushman              FD, Costello              EK, Fierer              N, Pe\u00f1a              AG, Goodrich              JK, Gordon              JI, et            al. 2010. QIIME allows analysis of            high-throughput community sequencing data. Nat            Methods 7: 335\u2013336.","DOI":"10.1038\/nmeth.f.303"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Li              P, Stuart              EA, Allison              DB. 2015.            Multiple imputation: a flexible tool for handling missing            data. JAMA 314:            1966\u20131967.","DOI":"10.1001\/jama.2015.15281"},{"key":"51","first-page":"28","volume":"34","year":"1947","unstructured":"51. Welch              BL. 1947.            The generalisation of student\u2019s problems when several different            population variances are involved. Biometrika 34: 28\u201335.","journal-title":"Biometrika","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3444","issn-type":"print"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Bharucha              AE. 2007.            Constipation. Best Pract Res Clin            Gastroenterol 21: 709\u2013731.","DOI":"10.1016\/j.bpg.2007.07.001"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Ohkusa              T, Koido              S, Nishikawa              Y, Sato              N. 2019.            Gut microbiota and chronic constipation: a review and            update. Front Med (Lausanne) 6:            19.","DOI":"10.3389\/fmed.2019.00019"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Dimidi              E,                Christodoulides              S, Scott              SM, Whelan              K. 2017.            Mechanisms of action of probiotics and the gastrointestinal microbiota on            gut motility and constipation. Adv Nutr 8: 484\u2013494.","DOI":"10.3945\/an.116.014407"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Chassard              C, Dapoigny              M, Scott              KP, Crouzet              L, Del\u2019homme              C, Marquet              P, Martin              JC, Pickering              G, Ardid              D, Eschalier              A, et            al. 2012. Functional dysbiosis within            the gut microbiota of patients with constipated-irritable bowel          syndrome. Aliment Pharmacol Ther 35:            828\u2013838.","DOI":"10.1111\/j.1365-2036.2012.05007.x"},{"key":"56","doi-asserted-by":"publisher","unstructured":"56. Parthasarathy              G, Chen              J, Chen              X, Chia              N, O\u2019Connor              HM, Wolf              PG, Gaskins              HR, Bharucha              AE. 2016.            Relationship between microbiota of the colonic mucosa vs feces and            symptoms, colonic transit, and methane production in female patients with chronic            constipation. Gastroenterology 150:            367\u201379.e1.","DOI":"10.1053\/j.gastro.2015.10.005"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Dimidi              E, Mark Scott              S, Whelan              K. 2020.            Probiotics and constipation: mechanisms of action, evidence for            effectiveness and utilisation by patients and healthcare professionals.            Proc Nutr Soc 79:            147\u2013157.","DOI":"10.1017\/S0029665119000934"},{"key":"58","doi-asserted-by":"publisher","unstructured":"58. Holscher              HD. 2017.            Dietary fiber and prebiotics and the gastrointestinal            microbiota. Gut Microbes 8:            172\u2013184.","DOI":"10.1080\/19490976.2017.1290756"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Miyazawa              K, Yoda              K, Harata              G, Ida              M, Hirayama              I, Fang              HE, Hiramatsu              M. 2017.            Effects of ingesting <i>Lactobacillus rhamnosus<\/i> GG on            defecation, fecal properties and skin condition in healthy female volunteers with            constipation tendency. Nihon Nyusankin            Gakkaishi 28:          12\u201317.","DOI":"10.4109\/jslab.28.12"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Mori              N, Kano              M, Masuoka              N, Konno              T, Suzuki              Y, Miyazaki              K, Ueki              Y. 2016.            Effect of probiotic and prebiotic fermented milk on skin and intestinal            conditions in healthy young female students. Biosci Microbiota            Food Health 35: 105\u2013112.","DOI":"10.12938\/bmfh.2015-022"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Costa              ML, Oliveira              JN, Tahan              S, Morais              MB. 2011.            Overweight and constipation in adolescents. BMC            Gastroenterol 11: 40.","DOI":"10.1186\/1471-230X-11-40"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Smith-Norowitz              TA, Bluth              MH. 2016.            Probiotics and diseases of altered IgE regulation: a short            review. J Immunotoxicol 13:            136\u2013140.","DOI":"10.3109\/1547691X.2015.1044053"},{"key":"63","doi-asserted-by":"publisher","unstructured":"63. Park              S, Zhang              T, Qiu              JY, Wu              X, Lee              JY, Lee              BY. 2020.            Acid hydrolyzed silk peptide consumption improves anti-diabetic symptoms            by potentiating insulin secretion and preventing gut microbiome dysbiosis in non-obese            type 2 diabetic animals. Nutrients 12:            311.","DOI":"10.3390\/nu12020311"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Xourgia              E,                Papazafiropoulou              A, Papanas              N, Melidonis              A. 2019.            Anti-diabetic treatment leads to changes in gut            microbiome. Front Biosci (Landmark Ed) 24: 688\u2013699.","DOI":"10.2741\/4743"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Kunz              RI,                Brancalh\u00e3o              RMC, Ribeiro              LFC, Natali              MRM. 2016.            Silkworm sericin: properties and biomedical applications.            BioMed Res Int 2016: 8175701.","DOI":"10.1155\/2016\/8175701"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Ben Bra\u00efek              O, Smaoui              S. 2019.            Enterococci: between emerging pathogens and potential            probiotics. BioMed Res Int 2019:            5938210.","DOI":"10.1155\/2019\/5938210"},{"key":"67","doi-asserted-by":"publisher","unstructured":"67. Krawczyk              B, Wityk              P, Ga\u0142\u0119cka              M, Michalik              M. 2021.            The many faces of <i>Enterococcus<\/i> spp.\u2014commensal, probiotic            and opportunistic pathogen. Microorganisms 9: 1900.","DOI":"10.3390\/microorganisms9091900"},{"key":"68","doi-asserted-by":"publisher","unstructured":"68. Ouwehand              AC, Salminen              S, Isolauri              E. 2002.            Probiotics: an overview of beneficial effects.            Antonie van Leeuwenhoek 82:            279\u2013289.","DOI":"10.1023\/A:1020620607611"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Marteau              P, Seksik              P, Lepage              P, Dor\u00e9              J. 2004.            Cellular and physiological effects of probiotics and            prebiotics. Mini Rev Med Chem 4:            889\u2013896.","DOI":"10.2174\/1389557043403369"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Tsukahara              T, Bukawa              W, Kan              T, Ushida              K. 2005.            Effect of a cell preparation of <i>Enterococcus faecalis<\/i>            strain EC-12 on digesta flow recovery from constipation in a pig model and human            subjects. Microb Ecol Health Dis 17:            107\u2013113.","DOI":"10.1080\/08910600510044507"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Inatomi              T, Honma              M. 2021.            Effects of probiotics on loperamide-induced constipation in            rats. Sci Rep 11:          24098.","DOI":"10.1038\/s41598-021-02931-7"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Zhang              X, Hu              L, Li              L, Wang              Y, Zhang              C, Su              J, Di              H, Gao              Q, Tai              X, Guo              T. 2022.            Pediatric <i>Tuina<\/i> for functional constipation in children:            study protocol for a randomized controlled trail.            Trials 23: 750.","DOI":"10.1186\/s13063-022-06678-y"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. D\u00fcrre              P. 2014.            Physiology and sporulation in            <i>Clostridium<\/i>. Microbiol Spectr 2: TBS-0010\u2013TBS-2012.","DOI":"10.1128\/microbiolspec.TBS-0010-2012"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Yaghoubi              A, Ghazvini              K, Khazaei              M, Hasanian              SM, Avan              A,                Soleimanpour              S. 2022.            The use of <i>Clostridium<\/i> in cancer therapy: a promising            way. Rev Res Med Microbiol 33:            121\u2013127.","DOI":"10.1097\/MRM.0000000000000281"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Lee              JC, Chiu              CW, Tsai              PJ, Lee              CC, Huang              IH, Ko              WC, Hung              YP. 2022.              <i>Clostridium butyricum<\/i> therapy for mild-moderate              <i>Clostridioides difficile<\/i> infection and the impact of diabetes            mellitus. Biosci Microbiota Food Health 41: 37\u201344.","DOI":"10.12938\/bmfh.2021-049"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Wilkens              E, Ringel              AK, Hortig              D, Willke              T, Vorlop              KD. 2012.            High-level production of 1,3-propanediol from crude glycerol by              <i>Clostridium butyricum<\/i> AKR102a. Appl Microbiol            Biotechnol 93: 1057\u20131063.","DOI":"10.1007\/s00253-011-3595-6"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Ma              C, Ou              J, Miller              M, McFann              S, Liu              X. 2015.            High production of butyric acid by <i>Clostridium              tyrobutyricum<\/i> mutant. Front Chem Sci            Eng 9: 369\u2013375.","DOI":"10.1007\/s11705-015-1525-3"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Fukumoto              S, Tatewaki              M, Yamada              T, Fujimiya              M, Mantyh              C, Voss              M, Eubanks              S, Harris              M, Pappas              TN, Takahashi              T. 2003.            Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT            release in rats. Am J Physiol Regul Integr Comp            Physiol 284: R1269\u2013R1276.","DOI":"10.1152\/ajpregu.00442.2002"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Wang              L, Cen              S, Wang              G, Lee              YK, Zhao              J, Zhang              H, Chen              W. 2020.            Acetic acid and butyric acid released in large intestine play different            roles in the alleviation of constipation. J Funct            Foods 69: 103953.","DOI":"10.1016\/j.jff.2020.103953"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Pituch              A, Walkowiak              J,                Banaszkiewicz              A. 2013.            Butyric acid in functional constipation. Prz            Gastroenterol 8: 295\u2013298.","DOI":"10.5114\/pg.2013.38731"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Koh              GY, Kane              A, Lee              K, Xu              Q, Wu              X, Roper              J, Mason              JB, Crott              JW. 2018.              <i>Parabacteroides distasonis<\/i> attenuates toll-like            receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat            diet-fed azoxymethane-treated mice. Int J            Cancer 143: 1797\u20131805.","DOI":"10.1002\/ijc.31559"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Boureau              H, Decr\u00e9              D, Carlier              JP, Guichet              C, Bourlioux              P. 1993.            Identification of a <i>Clostridium cocleatum<\/i> strain            involved in an anti-<i>Clostridium difficile<\/i> barrier effect and            determination of its mucin-degrading enzymes. Res            Microbiol 144: 405\u2013410.","DOI":"10.1016\/0923-2508(93)90198-B"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Kim              DW, Hwang              HS, Kim              DS, Sheen              SH, Heo              DH, Hwang              G, Kang              SH, Kweon              H, Jo              YY, Kang              SW, et            al. 2011. Effect of silk fibroin            peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in            a mice edema model. BMB Rep 44:            787\u2013792.","DOI":"10.5483\/BMBRep.2011.44.12.787"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Rahimpour              S, Jabbari              H, Yousofi              H, Fathi              A, Mahmoodi              S, Jafarian              MJ, Shomali              N, Shotorbani              SS. 2023.            Regulatory effect of sericin protein in inflammatory pathways; a            comprehensive review. Pathol Res Pract 243: 154369.","DOI":"10.1016\/j.prp.2023.154369"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Salminen              S, Collado              MC, Endo              A, Hill              C, Lebeer              S, Quigley              EMM, Sanders              ME, Shamir              R, Swann              JR, Szajewska              H, et            al. 2021. The International Scientific            Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition            and scope of postbiotics. 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