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Cheng              C, Wang              Q, Huang              Y, Xue              Q, Wang              Y, Wu              P, Liao              F, Miao              C. 2023.            Gandouling inhibits hepatic fibrosis in Wilson\u2019s disease through            Wnt-1\/\u03b2-catenin signaling pathway. J            Ethnopharmacol 311: 116445.","DOI":"10.1016\/j.jep.2023.116445"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Zhang              J, Xiao              L, Yang              W. 2020.            Combined sodium Dimercaptopropanesulfonate and zinc versus            D-penicillamine as first-line therapy for neurological Wilson\u2019s disease.            BMC Neurol 20: 255.","DOI":"10.1186\/s12883-020-01827-9"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Tang              L, Zhao              C, Zhang              J, Dong              T, Chen              H, Wei              T, Wang              J, Yang              W. 2023.            Discussion on the mechanism of gandoufumu decoction attenuates liver            damage of Wilson\u2019s disease by inhibiting autophagy through the PI3K\/Akt\/mTOR pathway            based on network pharmacology and experimental verification.            Mediators Inflamm 2023: 3236911.","DOI":"10.1155\/2023\/3236911"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Iwa\u0144ski              S, Seni\u00f3w              J, Le\u015bniak              M, Litwin              T,                Cz\u0142onkowska              A. 2015.            Diverse attention deficits in patients with neurologically symptomatic            and asymptomatic Wilson\u2019s disease.            Neuropsychology 29:            25\u201330.","DOI":"10.1037\/neu0000103"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Gerosa              C, Fanni              D, Congiu              T, Piras              M, Cau              F, Moi              M, Faa              G. 2019.            Liver pathology in Wilson\u2019s disease: from copper overload to            cirrhosis. J Inorg Biochem 193:            106\u2013111.","DOI":"10.1016\/j.jinorgbio.2019.01.008"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Bandmann              O, Weiss              KH, Kaler              SG. 2015.            Wilson\u2019s disease and other neurological copper disorders.            Lancet Neurol 14:            103\u2013113.","DOI":"10.1016\/S1474-4422(14)70190-5"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Xia              S, Huang              Y, Zhang              Y, Zhang              M, Zhao              K, Han              P, Tian              D, Liao              J, Liu              J. 2023.            Role of macrophage-to-myofibroblast transition in chronic liver injury            and liver fibrosis. Eur J Med Res 28:            502.","DOI":"10.1186\/s40001-023-01488-7"},{"key":"8","unstructured":"8. Zhang              W, Shao              M, Zhang              H, Wu              Z, Miao              T, Zheng              H, Xie              X, Wang              R. 2018.            Study on the regulation of miR-122 gene related factors expression in            liver fibrosis by Fuzheng Huayu tablets. J Beijing Univ            Traditional Chinese Med 41:            76\u201382 (in Chinese)."},{"key":"9","unstructured":"9. Lu              WM, Yan              LX, Ye              JS, Du              J, Zhou              L. 2024.            Progress of mesenchymal stem cell exosomes in the treatment of liver            fibrosis. JiangXi Medical Journal 59:            509\u2013513(Chinese)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Zhang              Z, Yuan              Y, Hu              L, Tang              J, Meng              Z, Dai              L, Gao              Y, Ma              S, Wang              X, Yuan              Y, et            al. 2023. ANGPTL8 accelerates liver            fibrosis mediated by HFD-induced inflammatory activity via LILRB2\/ERK signaling            pathways. J Adv Res 47:            41\u201356.","DOI":"10.1016\/j.jare.2022.08.006"},{"key":"11","unstructured":"11. Wang              N, Wu              W, Wen              B, Deng              X. 2024.            Research progress of traditional Chinese medicine and hepaticfibrosis            based on the theory of \u201cgut-liver axis\u201d. J Shanxi Univ            Traditional Chinese Med 25: 109\u2013112, 118 (in          Chinese)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Collins              SL, Stine              JG, Bisanz              JE, Okafor              CD, Patterson              AD. 2023.            Bile acids and the gut microbiota: metabolic interactions and impacts on            disease. Nat Rev Microbiol 21:            236\u2013247.","DOI":"10.1038\/s41579-022-00805-x"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Ch\u00e1vez-Talavera              O, Tailleux              A, Lefebvre              P, Staels              B. 2017.            Bile acid control of metabolism and inflammation in obesity, type 2            diabetes, dyslipidemia, and nonalcoholic fatty liver disease.            Gastroenterology 152:          1679\u20131694.e3.","DOI":"10.1053\/j.gastro.2017.01.055"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Xie              G, Wang              X, Huang              F, Zhao              A, Chen              W, Yan              J, Zhang              Y, Lei              S, Ge              K, Zheng              X, et            al. 2016. Dysregulated hepatic bile            acids collaboratively promote liver carcinogenesis. Int J            Cancer 139: 1764\u20131775.","DOI":"10.1002\/ijc.30219"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Zhang              HL, Yu              LX, Yang              W, Tang              L, Lin              Y, Wu              H, Zhai              B, Tan              YX, Shan              L, Liu              Q, et            al. 2012. Profound impact of gut            homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis            in rats. J Hepatol 57:            803\u2013812.","DOI":"10.1016\/j.jhep.2012.06.011"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Soca\u0142a              K,                Doboszewska              U, Szopa              A, Serefko              A, W\u0142odarczyk              M, Zieli\u0144ska              A, Poleszak              E, Fichna              J, Wla\u017a              P. 2021.            The role of microbiota-gut-brain axis in neuropsychiatric and            neurological disorders. Pharmacol Res 172: 105840.","DOI":"10.1016\/j.phrs.2021.105840"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Guan              H, Zhang              X, Kuang              M, Yu              J. 2022.            The gut-liver axis in immune remodeling of hepatic            cirrhosis. Front Immunol 13:            946628.","DOI":"10.3389\/fimmu.2022.946628"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Milosevic              I, Vujovic              A, Barac              A, Djelic              M, Korac              M, Radovanovic                Spurnic              A, Gmizic              I, Stevanovic              O, Djordjevic              V, Lekic              N, et            al. 2019. Gut-liver axis, gut            microbiota, and its modulation in the management of liver diseases: a review of the            literature. Int J Mol Sci 20:            395.","DOI":"10.3390\/ijms20020395"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Wang              L, Cao              ZM, Zhang              LL, Li              JM, Lv              WL. 2022.            The role of gut microbiota in some liver diseases: from an immunological            perspective. Front Immunol 13:            923599.","DOI":"10.3389\/fimmu.2022.923599"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Lee              NY, Suk              KT. 2020.            The role of the gut microbiome in liver cirrhosis            treatment. Int J Mol Sci 22:            199.","DOI":"10.3390\/ijms22010199"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Zhang              YL, Li              ZJ, Gou              HZ, Song              XJ, Zhang              L. 2022.            The gut microbiota-bile acid axis: a potential therapeutic target for            liver fibrosis. Front Cell Infect Microbiol 12: 945368.","DOI":"10.3389\/fcimb.2022.945368"},{"key":"22","unstructured":"22. Wei              TH, Qian              NN, Yang              WM, Xie              DJ, Bao              YC, Tong              JB, Hao              WJ, Yang              Y. 2022.            Exploring the clinical characteristics of liver fibrosis in Wilson\u2019s            disease of different Chinese medicine certificates based on liver stiffness value            combined with multidimensional indexes. Chinese J Integrative            Med Cardio-\/Cerebrovascuiar Disease 20:            2738-2742 (in Chinese)."},{"key":"23","unstructured":"23. Dong              W, Hao              WJ, Yang              WM, Huang              P. 2023.            Study on the correlation between the degree of hepatic fibrosis and            Chinese medicine evidence in hepatoblastic nuclear degeneration.            J Anhui Univ Chinese Med 42:            19\u201323(Chinese)."},{"key":"24","unstructured":"24. Neurogenetics            Group, Neurology Branch, Chinese Medical Association. 2021.            Chinese guidelines for the diagnosis and treatment of hepatolenticular            degeneration 2021. Chin J Neurol 54:            310\u2013319 (in Chinese)."},{"key":"25","unstructured":"25. Xu              L, Liu              P, Shen              X, Wu              Y, Ping              J. 2019.            Guidelines for the diagnosis and treatment of liver fibrosis by combining            traditional chinese and western medicine (2019 edition). Chinese            J Integrated Traditional Western Med 39:            1286\u20131295 (in Chinese)."},{"key":"26","unstructured":"26. Neurogenetics            Group of the Neurology Section of the Chinese Medical Association.            2021. Guidelines for the diagnosis and treatment of            hepatomegaly in China 2021. Chin J Neurol 54: 310\u2013319 (in          Chinese)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Liu              YT, Qi              SL, Sun              KW. 2021.            Traditional Chinese medicine, liver fibrosis, intestinal flora: is there            any connection?\u2014a narrative review. Ann Palliat            Med 10: 4846\u20134857.","DOI":"10.21037\/apm-20-2129"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Albhaisi              SAM, Bajaj              JS, Sanyal              AJ. 2020.            Role of gut microbiota in liver disease. Am J            Physiol Gastrointest Liver Physiol 318:            G84\u2013G98.","DOI":"10.1152\/ajpgi.00118.2019"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Pushpanathan              P, Mathew              GS,                Selvarajan              S, Seshadri              KG, Srikanth              P. 2019.            Gut microbiota and its mysteries. Indian J Med            Microbiol 37: 268\u2013277.","DOI":"10.4103\/ijmm.IJMM_19_373"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. Chen              T, Ding              R, Chen              X, Lu              Y, Shi              J, L\u00fc              Y, Tang              B, Zhang              W, Ye              C, Yuan              M, et            al. 2021. <i>Firmicutes<\/i>            and <i>Blautia<\/i> in gut microbiota lessened in chronic liver diseases and            hepatocellular carcinoma patients: a pilot study.            Bioengineered 12:            8233\u20138246.","DOI":"10.1080\/21655979.2021.1982273"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Seong              CN, Kang              JW, Lee              JH, Seo              SY, Woo              JJ, Park              C, Bae              KS, Kim              MS. 2018.            Taxonomic hierarchy of the phylum Firmicutes and novel Firmicutes species            originated from various environments in Korea. J            Microbiol 56: 1\u201310.","DOI":"10.1007\/s12275-018-7318-x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Binda              C, Lopetuso              LR, Rizzatti              G, Gibiino              G, Cennamo              V, Gasbarrini              A. 2018.            Actinobacteria: a relevant minority for the maintenance of gut            homeostasis. Dig Liver Dis 50:            421\u2013428.","DOI":"10.1016\/j.dld.2018.02.012"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Usami              M, Miyoshi              M, Yamashita              H. 2015.            Gut microbiota and host metabolism in liver cirrhosis.            World J Gastroenterol 21:            11597\u201311608.","DOI":"10.3748\/wjg.v21.i41.11597"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Ashour              Z, Shahin              R, Ali-Eldin              Z, El-Shayeb              M, El-Tayeb              T, Bakr              S. 2022.            Potential impact of gut <i>Lactobacillus acidophilus<\/i> and              <i>Bifidobacterium bifidum<\/i> on hepatic histopathological changes in            non-cirrhotic hepatitis C virus patients with different viral load.            Gut Pathog 14: 25.","DOI":"10.1186\/s13099-022-00501-4"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Corth\u00e9sy              B, Gaskins              HR, Mercenier              A. 2007.            Cross-talk between probiotic bacteria and the host immune            system. J Nutr 137 Suppl            2: 781S\u2013790S.","DOI":"10.1093\/jn\/137.3.781S"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Xue              L, He              J, Gao              N, Lu              X, Li              M, Wu              X, Liu              Z, Jin              Y, Liu              J, Xu              J, et            al. 2017. Probiotics may delay the            progression of nonalcoholic fatty liver disease by restoring the gut microbiota            structure and improving intestinal endotoxemia. Sci            Rep 7: 45176.","DOI":"10.1038\/srep45176"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Cuesta              S, Burdisso              P, Segev              A, Kourrich              S, Sperandio              V. 2022.            Gut colonization by Proteobacteria alters host metabolism and modulates            cocaine neurobehavioral responses. Cell Host            Microbe 30: 1615\u20131629.e5.","DOI":"10.1016\/j.chom.2022.09.014"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Mou              H, Yang              F, Zhou              J, Bao              C. 2018.            Correlation of liver function with intestinal flora, vitamin deficiency            and IL-17A in patients with liver cirrhosis. Exp Ther            Med 16: 4082\u20134088.","DOI":"10.3892\/etm.2018.6663"},{"key":"39","unstructured":"39. Wang              C, Ji              Y. 2021.            Preliminary study and application of the theory of \u201cconnection between            the liver and the large intestine\u201d. J Zhejiang Chinese Med            Univ 45: 339\u2013344 (in            Chinese)."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Szabo              G, Bala              S, Petrasek              J, Gattu              A. 2010.            Gut-liver axis and sensing microbes. Dig            Dis 28: 737\u2013744.","DOI":"10.1159\/000324281"},{"key":"41","unstructured":"41. Huang              P, Dong              T, Li              X, Wang              H, Wang              MX, Yang              WM. 2022.            Comparison the changes of related indexes of different traditional            Chinese medicine syndrome types in patients with hepatolenticular            degeneration. 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