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Farthing              M, Salam              MA, Lindberg              G, Dite              P, Khalif              I,                Salazar-Lindo              E,                Ramakrishna              BS, Goh              KL, Thomson              A, Khan              AG, et            al. WGO2013.            Acute diarrhea in adults and children: a global            perspective. J Clin Gastroenterol 47:            12\u201320.","DOI":"10.1097\/MCG.0b013e31826df662"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Schiller              LR, Pardi              DS, Sellin              JH. 2017.            Chronic diarrhea: diagnosis and management. Clin            Gastroenterol Hepatol 15:            182\u2013193.e3.","DOI":"10.1016\/j.cgh.2016.07.028"},{"key":"3","unstructured":"3. GBD 2016            Diarrhoeal Disease Collaborators2018.            Estimates of the global, regional, and national morbidity, mortality, and            aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden            of Disease Study 2016. Lancet Infect Dis 18: 1211\u20131228."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hartman              RM, Cohen              AL, Antoni              S, Mwenda              J,                Weldegebriel              G, Biey              J, Shaba              K, de                Oliveira              L, Rey              G, Ortiz              C, et            al. 2023. Risk factors for mortality            among children younger than age 5 years with severe diarrhea in low- and middle-income            countries: findings from the world health organization-coordinated global rotavirus and            pediatric diarrhea surveillance networks. Clin Infect            Dis 76: e1047\u2013e1053.","DOI":"10.1093\/cid\/ciac561"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Zhang              CY, Peng              XX, Shao              HQ, Li              XY, Wu              Y, Tan              ZJ. 2021.            Gut microbiota comparison between intestinal contents and mucosa in mice            with repeated stress-related diarrhea provides novel insight.            Front Microbiol 12: 626691.","DOI":"10.3389\/fmicb.2021.626691"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Paone              P, Cani              PD. 2020.            Mucus barrier, mucins and gut microbiota: the expected slimy            partners? Gut 69:            2232\u20132243.","DOI":"10.1136\/gutjnl-2020-322260"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Yang              Q, Wang              Y, Jia              A, Wang              Y, Bi              Y, Liu              G. 2021.            The crosstalk between gut bacteria and host immunity in intestinal            inflammation. J Cell Physiol 236:            2239\u20132254.","DOI":"10.1002\/jcp.30024"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Turner              JR. 2009.            Intestinal mucosal barrier function in health and          disease. Nat Rev Immunol 9:            799\u2013809.","DOI":"10.1038\/nri2653"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. An              J, Liu              Y, Wang              Y, Fan              R, Hu              X, Zhang              F, Yang              J, Chen              J. 2022.            The role of intestinal mucosal barrier in autoimmune disease: a potential            target. Front Immunol 13:            871713.","DOI":"10.3389\/fimmu.2022.871713"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Untersmayr              E, Brandt              A, Koidl              L, Bergheim              I. 2022.            The intestinal barrier dysfunction as driving factor of            inflammaging. Nutrients 14:            949.","DOI":"10.3390\/nu14050949"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Thursby              E, Juge              N. 2017.            Introduction to the human gut microbiota. Biochem            J 474: 1823\u20131836.","DOI":"10.1042\/BCJ20160510"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Fu              Q, Song              T, Ma              X, Cui              J. 2022.            Research progress on the relationship between intestinal microecology and            intestinal bowel disease. Animal Model Exp Med 5: 297\u2013310.","DOI":"10.1002\/ame2.12262"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Carding              S, Verbeke              K, Vipond              DT, Corfe              BM, Owen              LJ. 2015.            Dysbiosis of the gut microbiota in disease.            Microb Ecol Health Dis 26: 26191.","DOI":"10.3402\/mehd.v26.26191"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Piovezani Ramos              G, Camilleri              M. 2023.            Current and future therapeutic options for irritable bowel syndrome with            diarrhea and functional diarrhea. Dig Dis Sci 68: 1677\u20131690.","DOI":"10.1007\/s10620-022-07700-8"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Yao              CJ, Li              YL, Pu              MJ, Luo              LH, Feng              PM. 2020.            Traditional Chinese medicine for irritable bowel syndrome: a protocol for            meta-analysis. Medicine (Baltimore) 99: e23394.","DOI":"10.1097\/MD.0000000000023394"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Meng              M, Bai              C, Wan              B, Zhao              L, Li              Z, Li              D, Zhang              S. 2021.            A network pharmacology-based study on irritable bowel syndrome prevention            and treatment utilizing Shenling Baizhu powder. BioMed Res            Int 2021: 4579850.","DOI":"10.1155\/2021\/4579850"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Liu              J, Qiao              B, Cai              Y, Tan              Z, Deng              N. 2023.            Diarrhea accompanies intestinal inflammation and intestinal mucosal            microbiota dysbiosis during fatigue combined with a high-fat diet.            BMC Microbiol 23: 151.","DOI":"10.1186\/s12866-023-02896-9"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Liu              J, Qiao              B, Deng              N, Wu              Y, Li              D, Tan              Z. 2023.            The diarrheal mechanism of mice with a high-fat diet in a fatigued state            is associated with intestinal mucosa microbiota. 3            Biotech 13: 77.","DOI":"10.1007\/s13205-023-03491-5"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Qiao              B, Liu              J, Deng              N, Cai              Y, Bian              Y, Wu              Y, Tan              Z, Tan              Z. 2023.            Gut content microbiota dysbiosis and dysregulated lipid metabolism in            diarrhea caused by high-fat diet in a fatigued state. Food            Funct 14: 3880\u20133892.","DOI":"10.1039\/D3FO00378G"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Qiao              B, Liu              J, Peng              X, Cai              Y, Peng              M, Li              X, Tan              Z, Deng              N. 2023.            Association of short-chain fatty acids with gut microbiota and lipid            metabolism in mice with diarrhea induced by high-fat diet in a fatigued            state. Mol Nutr Food Res 67:            e2300452.","DOI":"10.1002\/mnfr.202300452"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Peng              X, Yi              X, Deng              N, Liu              J, Tan              Z, Cai              Y. 2023.            Zhishi Daozhi decoction alleviates constipation induced by a high-fat and            high-protein diet via regulating intestinal mucosal microbiota and oxidative            stress. Front Microbiol 14:            1214577.","DOI":"10.3389\/fmicb.2023.1214577"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Di              J, Guo              M, Peng              M, Fang              L, Shen              J, Xiao              N, Tan              Z. 2025.            Effect of sodium butyrate and Sishen pill combination on diarrhea with            kidney-Yang deficiency syndrome was associated with intestinal mucosal microbiota and            immune barrier. J Inflamm Res 18:            10467\u201310487.","DOI":"10.2147\/JIR.S518370"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Qiao              B, Xiao              N, Deng              N, Tan              Z. 2024.            Shenling Baizhu powder attenuates lard diet in a fatigued state-induced            diarrhea via targeting microbial metabolites short chain fatty acids-mediated lipid            metabolism. 3 Biotech 14:            203.","DOI":"10.1007\/s13205-024-04045-z"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Chen              J, Shen              B, Jiang              Z. 2022.            Traditional Chinese medicine prescription Shenling BaiZhu powder to treat            ulcerative colitis: clinical evidence and potential mechanisms.            Front Pharmacol 13: 978558.","DOI":"10.3389\/fphar.2022.978558"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Wang              H, Hou              YN, Yang              M, Feng              Y, Zhang              YL, Smith              CM, Hou              W, Mao              JJ, Deng              G. 2022.            Herbal formula Shenling Baizhu San for chronic diarrhea in adults: a            systematic review and meta-analysis. Integr Cancer            Ther 21: 15347354221081214.","DOI":"10.1177\/15347354221081214"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Wu              Y, Peng              X, Li              X, Li              D, Tan              Z, Yu              R. 2022.            Sex hormones influence the intestinal microbiota composition in            mice. Front Microbiol 13:            964847.","DOI":"10.3389\/fmicb.2022.964847"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Liu              J, Wu              Y, Cai              Y, Tan              Z, Deng              N.              2023. Long-term consumption of different            doses of <i>Grifola frondosa<\/i> affects immunity and metabolism: correlation            with intestinal mucosal microbiota and blood lipids. 3            Biotech 13: 189.","DOI":"10.1007\/s13205-023-03617-9"},{"key":"28","unstructured":"28. Tao              H. 2020. The          Formulaology of TCM. Shandong Science &amp; Technology Press, Shandong, pp.          76\u2013109."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Zhu              J, Li              X, Deng              N, Zhou              K, Qiao              B, Li              D, Tan              Z. 2023.            Intestinal mucosal flora of the intestine-kidney remediation process of            diarrhea with deficiency kidney-Yang syndrome in Sishen Pill treatment: association with            interactions between <i>Lactobacillus johnsonii<\/i>,              Ca<sup>2+<\/sup>-Mg<sup>2+<\/sup>-ATP-ase, and            Na<sup>+<\/sup>-K<sup>+<\/sup>-ATP-ase. Heliyon 9: e16166.","DOI":"10.1016\/j.heliyon.2023.e16166"},{"key":"30","unstructured":"30. Lu              C, Zhou              L, Cao              D, Wang              SG, Yang              XJ. 1999.            Experimental study on the effect of Shenling Baizhu Granule on splenic            strength of mice with spleen deficiency syndrome. Zhongguo            Shiyan Fangjixue Zazhi41\u201343."},{"key":"31","unstructured":"31. Li              Y, Han              Y, Zhu              K. 2011.            Comprehensive evaluation of symptoms of spleen deficiency model mice by            eating disorder method. Hunan Journal of Traditional Chinese            Medicine. 27:          126\u2013127."},{"key":"32","unstructured":"32. Ma              J, Liu              J, Liu              Y, Li              F, Song              YH, Han              CX. 2015.            Based on behavioral experiments to explore the weary change of small            platform station water environment model. Acta Chinese            Medicine. 30:          843\u2013845."},{"key":"33","unstructured":"33. Yang              X, Li              F, Ma              J, Mao              M, Wu              F, Du              Q, Wang              S. 2016.            Establishment and evaluation of a spleen-deficiency rat model by small            platform with water beneath. Shandong Journal of Traditional            Chinese Medicine. 35:          452\u2013457."},{"key":"34","unstructured":"34. Gao              YX, Li              H, Song              L, Wu              Y, Chen              FT, Ye              H. 2022.            Pharmacodynamic study of Shenling Jianpiwei Keii on gastrointesinal            regulation in spleen deficiency model rats. Yaowu Pingjia            Yanjiu 45:          1992\u20132001."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Xie              G, Tan              K, Peng              M, Long              C, Li              D, Tan              Z. 2019.            Bacterial diversity in intestinal mucosa of antibiotic-associated            diarrhea mice. 3 Biotech 9:            444.","DOI":"10.1007\/s13205-019-1967-2"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Camilleri              M, Madsen              K, Spiller              R, Greenwood-Van                Meerveld              B, Verne              GN. 2012.            Intestinal barrier function in health and gastrointestinal            disease. Neurogastroenterol Motil 24:            503\u2013512.","DOI":"10.1111\/j.1365-2982.2012.01921.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Tatiya-Aphiradee              N,                Chatuphonprasert              W,                Jarukamjorn              K. 2018.            Immune response and inflammatory pathway of ulcerative            colitis. J Basic Clin Physiol Pharmacol 30: 1\u201310.","DOI":"10.1515\/jbcpp-2018-0036"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Chen              XW, Zhou              SF. 2015.            Inflammation, cytokines, the IL-17\/IL-6\/STAT3\/NF-\u03baB axis, and            tumorigenesis. Drug Des Devel Ther 9:            2941\u20132946.","DOI":"10.2147\/DDDT.S86396"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Pietrzak              B, Tomela              K,                Olejnik-Schmidt              A, Mackiewicz              A, Schmidt              M. 2020.            Secretory IgA in intestinal mucosal secretions as an adaptive barrier            against microbial cells. Int J Mol Sci 21: 9254.","DOI":"10.3390\/ijms21239254"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Panah              FM, Lauridsen              C, H\u00f8jberg              O, Jensen              HE, Nielsen              TS. 2023.            Composition of mucus- and digesta-associated bacteria in growing pigs            with and without diarrhea differed according to the presence of colonic            inflammation. BMC Microbiol 23:            145.","DOI":"10.1186\/s12866-023-02874-1"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Liu              B, Yu              D, Ge              C, Luo              X, Du              L, Zhang              X, Hui              C. 2023.            Combined effects of microplastics and chlortetracycline on the intestinal            barrier, gut microbiota, and antibiotic resistome of Muscovy ducks (Cairina            moschata). Sci Total Environ 887:            164050.","DOI":"10.1016\/j.scitotenv.2023.164050"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Forster              SC, Clare              S,                Beresford-Jones              BS, Harcourt              K, Notley              G, Stares              MD, Kumar              N, Soderholm              AT, Adoum              A, Wong              H, et            al. 2022. Identification of gut            microbial species linked with disease variability in a widely used mouse model of            colitis. Nat Microbiol 7:            590\u2013599.","DOI":"10.1038\/s41564-022-01094-z"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Chang              CS, Liao              YC, Huang              CT, Lin              CM, Cheung              CHY, Ruan              JW, Yu              WH, Tsai              YT, Lin              IJ, Huang              CH, et            al. 2021. Identification of a gut            microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced            Dusp6-deficient mice. Cell Rep 37:            110016.","DOI":"10.1016\/j.celrep.2021.110016"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Chen              S, Li              Y, Chu              B, Yuan              L, Liu              N, Zhu              Y, Wang              J. 2021.              <i>Lactobacillus johnsonii<\/i> L531 alleviates the damage            caused by <i>Salmonella<\/i> Typhimurium via Inhibiting TLR4, NF-\u03baB, and NLRP3            inflammasome signaling pathways. Microorganisms 9: 1983.","DOI":"10.3390\/microorganisms9091983"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Nagano              T,                Higashimura              Y, Nakano              M, Nishiuchi              T, Lelo              AP. 2025.            High-viscosity dietary fibers modulate gut microbiota and liver            metabolism to prevent obesity in high-fat diet-fed mice. 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