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Here, we tested whether early-life aerobic exercise rescues hippocampus-dependent memory impairment and canonical Wnt\/\u03b2-catenin signaling deficits in offspring born to dams with streptozotocin-induced GDM. Pregnant C57BL\/6 mice received streptozotocin (40 mg\/kg, gestational day 7) or saline. Male offspring were weaned and assigned to sedentary control or treadmill exercise (15 m\/min, 60 min\/day, 5 days\/wk, 2 weeks), generat-ing four groups: saline control (Sal-CON, n=12), saline exercise (Sal-Ex, n=12), GDM control (GDM-CON, n=12), and GDM exercise (GDM-Ex, n=12). Spatial learning and reference memory were assessed using the Morris water maze, and spatial working memory was evaluated with a T-maze task. Hippocampal expression of Wnt3, \u03b2-catenin, and glycogen synthase kinase-3\u03b2 (GSK-3\u03b2) was quantified by Western blot-ting. GDM offspring exhibited impaired hippocampal memory perfor-mance, evidenced by a reduced hidden-to-visible platform latency ratio in the Morris water maze and loss of novelty preference in the T-maze. These behavioral deficits were accompanied by suppression of canon-ical Wnt signaling, with decreased hippocampal Wnt3 and \u03b2-catenin and increased GSK-3\u03b2 in GDM-CON compared with controls. Notably, postnatal treadmill exercise significantly improved both reference and working memory and normalized Wnt\/\u03b2-catenin pathway components in GDM offspring. Collectively, these findings indicate that early-life aer-obic exercise mitigates GDM-associated cognitive vulnerability, at least in part, by reactivating hippocampal Wnt\/\u03b2-catenin signaling.<\/jats:p>","DOI":"10.12965\/jer.2550884.442","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T23:25:23Z","timestamp":1771889123000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.12965\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postnatal treadmill exercise alleviates cognitive deficits in offspring exposed to gestational diabetes mellitus via reactivation of the hippocampal Wnt\/\u03b2-catenin signaling 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