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This product focus gives an overview of the inflammatory phase of the wound healing continuum; discusses how the imbalance of matrix metalloproteinases\/tissue inhibitors of matrix metalloproteinases occurs; how this imbalance manifests itself clinically within the wound; and what health professionals can do in order to tip the balance in favour of healing. It discusses a new wound dressing, Drawtex, which combines three modes of action to maintain a moist wound environment in order to debride, manage exudate and reduce bioburden by locking harmful proteases into its core. Case studies are presented where Drawtex has been used to achieve healing in wounds that were not responding to treatment. <\/jats:p>","DOI":"10.12968\/bjcn.2013.18.sup12.s42","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T17:44:12Z","timestamp":1403545452000},"page":"S42-S49","source":"Crossref","is-referenced-by-count":1,"title":["Drawtex: breaking the vicious circle of cellular and molecular imbalances"],"prefix":"10.12968","volume":"18","author":[{"given":"Annemarie","family":"Brown","sequence":"first","affiliation":[{"name":"Independent Consultant, Tissue Viability Solutions"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Yorke","sequence":"additional","affiliation":[{"name":"Clinical Manager, Solent NHS Trust Podiatry Team"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"issue":"1","key":"R1","first-page":"58","volume":"7","author":"Bianchi J","year":"2012","journal-title":"Wound Essentials"},{"key":"R3","volume-title":"Acute and Chronic Wounds","author":"Bryant R.","year":"2000","edition":"2"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"R5","volume-title":"Les Fontaines Publiques de la Ville de Dijon","author":"Darcy H","year":"1856"},{"key":"R6","volume-title":"Wound Healing and Skin Integrity","author":"Davis P","year":"2008"},{"issue":"3","key":"R9","first-page":"14","volume":"5","author":"Dowsett C","year":"2009","journal-title":"Wounds UK"},{"issue":"3","key":"R10","first-page":"58","volume":"1","author":"Dowsett C","year":"2005","journal-title":"Wounds UK"},{"issue":"4","key":"R15","first-page":"107","volume":"27","author":"Gray D","year":"2013","journal-title":"J Community Nursing"},{"issue":"11","key":"R17","first-page":"55","volume":"46","author":"Inlow S","year":"2000","journal-title":"Ostomy Wound Manage"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00321.x"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2006.15.Sup2.21237"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690040093015"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.7748\/ns2012.05.26.38.42.c9111"},{"key":"R24","volume-title":"In European Wound Management Association (EWMA) Position Document: Wound Bed Preparation in Practice","author":"Moffatt C","year":"2004"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00547.x"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2006.15.21.22374"},{"issue":"2","key":"R27","first-page":"76","volume":"2","author":"Mulder M","year":"2009","journal-title":"Wound Healing Southern Africa"},{"issue":"9","key":"R28","first-page":"6","volume":"24","author":"Ochs D","year":"2012","journal-title":"Wounds"},{"issue":"9","key":"R29","first-page":"3","volume":"24","author":"Ortiz RT","year":"2012","journal-title":"Wounds"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2010.15.Sup1.46908"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00184.x"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481x.2004.00007.x"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.11.628"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.11.s2.1.x"},{"issue":"11","key":"R37","first-page":"14","volume":"46","author":"Sibbald RG","year":"2000","journal-title":"Ostomy Wound Manage"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00388.x"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.03.009"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.4236\/ss.2013.45052"},{"issue":"7","key":"R41","first-page":"2","volume":"58","author":"Spruce P","year":"2012","journal-title":"Ostomy Wound Manage"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1999.00442.x"},{"issue":"9","key":"R43","first-page":"11","volume":"24","author":"Wendelken M","year":"2012","journal-title":"Wounds"},{"issue":"9","key":"R44","first-page":"14","volume":"24","author":"Wolcott RD","year":"2012","journal-title":"Wounds"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2008.17.8.30796"},{"issue":"9","key":"R46","first-page":"9","volume":"24","author":"Wolvos T","year":"2012","journal-title":"Wounds"},{"key":"R49","volume-title":"Principles of Best Practice: Wound Infection in Clinical Practice. 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