{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:20:46Z","timestamp":1777627246624,"version":"3.51.4"},"reference-count":29,"publisher":"Mark Allen Group","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nurs"],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:p> Haemoglobinopathies refer to a range of genetically inherited disorders of red blood cell haemoglobin and include sickle cell disorders and thalassaemias. They occur most commonly in populations whose ancestors come from Africa, Asia, Mediterranean Islands, and the Middle and Far East. Haemoglobin (Hb) abnormalities (or haemoglobinopathies) are caused by (i) abnormalities of the protein structure; (ii) imbalanced globin chain production owing to reduced rate of synthesis of normal a or b globin chains; or (iii) a combination of the two. This article will focus on the biological basis of sickle cell disorders and will discuss the history and pathology of the conditions. <\/jats:p>","DOI":"10.12968\/bjon.2006.15.18.22024","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T14:19:28Z","timestamp":1400854768000},"page":"994-998","source":"Crossref","is-referenced-by-count":2,"title":["Care of patients with haemoglobin abnormalities: history and biology"],"prefix":"10.12968","volume":"15","author":[{"given":"Ahmed D","family":"Khattab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Rawlings","sequence":"additional","affiliation":[{"name":"Institute of Health & Community Studies, Department of Nursing, Bournemouth University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtisam S","family":"Ali","sequence":"additional","affiliation":[{"name":"Royal Bournemouth Hospital."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"p_6","volume-title":"leading to synthesis of an abnormal haemoglobin, e.g. sickle cell disease (Hoffbrand et al","author":"Abnormalities","year":"2002"},{"key":"p_7","volume-title":"The globins produced in these disorders are structurally normal but their relative amounts are incorrect and therefore lead to the thalassaemias (Provan et al","author":"Imbalanced","year":"1997"},{"key":"p_8","volume-title":"abnormal structure and reduced rate of synthesis) (Turgeon","year":"2005"},{"key":"p_13","volume-title":"or with a carrier of another variant Hb (Allen","year":"2005"},{"key":"p_19","first-page":"25","volume":"275","author":"Allen S","year":"2005","journal-title":"The Pharmaceutical Journal"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.1996.tb00061.x"},{"key":"p_21","volume-title":"The Politics of Sickle Cell and Thalassaemia","author":"Anionwu EN","year":"2001"},{"key":"p_22","volume-title":"Hosp Phys Sept: 17-28","author":"Behrens RJ","year":"2000"},{"key":"p_23","volume-title":"Cecil Essentials of Medicine","author":"Berliner N","year":"2004","edition":"6"},{"key":"p_24","volume-title":"Sickle Cell Disease: Critical Elements of Care","author":"Centre","year":"2003","edition":"3"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.656"},{"key":"p_26","volume-title":"Southampton","author":"Davies SC","year":"2000"},{"key":"p_27","volume-title":"Sickle Cell Information Centre Protocols. 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