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Pharmacological therapies are useful in slowing disease progression and improving liver function tests; however, for many people liver transplantation is the only viable treatment for end-stage liver disease. This article provides an overview of the hypothesized aetiological factors, disease presentation, diagnosis and current treatment options. <\/jats:p>","DOI":"10.12968\/bjon.2008.17.9.29241","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T14:15:46Z","timestamp":1400854546000},"page":"566-570","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosing and treating a patient with primary biliary cirrhosis"],"prefix":"10.12968","volume":"17","author":[{"given":"Suzanne","family":"Sargent","sequence":"first","affiliation":[{"name":"Institute of Liver Studies"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Fullwood","sequence":"additional","affiliation":[{"name":"Liver Intensive Care Unit, King\u2019s College Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"p_2","volume-title":"There may also be a genetic component, as some studies have shown that first-degree relatives of patients with PBC are more likely to suffer from the disease (Levy and Lindor","author":"Poupon","year":"2003"},{"key":"p_3","volume-title":"McFarlane et al (2000)","author":"From","year":"2000"},{"key":"p_52","volume-title":"such as corticosteroids and cholestyramine (Newton et al","year":"2001"},{"key":"p_53","volume-title":"it may also be useful in aiding decisions regarding liver transplantation (Neuberger","author":"However","year":"2000"},{"key":"p_55","volume-title":"Nursing care and management of patients","author":"Davies A","year":"2007"},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.03.001"},{"key":"p_58","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20907"},{"key":"p_59","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5984"},{"key":"p_60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00471.x"},{"key":"p_61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043898"},{"key":"p_62","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06633-7.50019-3"},{"key":"p_63","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00006-0"},{"key":"p_64","volume-title":"Primary Biliary Cirrhosis.West End Studios LTD, United Kingdom","author":"Lombard M","year":"2000"},{"key":"p_65","volume-title":"Fast Facts: Liver Disorders","author":"Mahl T","year":"2006"},{"key":"p_66","volume-title":"Liver Disease and Laboratory Medicine","author":"McFarlane I","year":"2000"},{"key":"p_67","volume-title":"United Kingdom","author":"Neuberger J","year":"2000"},{"key":"p_68","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.2.282"},{"key":"p_69","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.qjmed.a030137"},{"key":"p_70","volume-title":"Hepatitis and Liver Disease","author":"Palmer M","year":"2004"},{"key":"p_71","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-03675-7.50023-8"},{"key":"p_72","volume-title":"Primary biliary cirrhosis emedicine. 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