{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:05:51Z","timestamp":1780445151807,"version":"3.54.1"},"reference-count":29,"publisher":"Mark Allen Group","issue":"Sup2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nurs"],"published-print":{"date-parts":[[2009,3,26]]},"abstract":"<jats:p> The management of hard-to-heal or chronic wounds places a high economic burden on healthcare services. This problem is exacerbated by the increasing age of the general population, an increasing diabetes population and a high prevalence of such wounds in the elderly, patients with diabetes and those with venous insufficiency. Standard treatments for such wounds, such as compression therapy in venous leg ulcers, debridement and wound care for diabetic foot ulcers, can still -leave a significant population with non-healing wounds, resulting in extended hospital stays and reduced quality of life. The use of amelogenin (Xelma<jats:sup>\u00ae&gt;<\/jats:sup>, M\u00f6lnlycke Health Care) for the treatment of a variety of chronic wounds has been assessed in both case studies and larger clinical trials with encouraging findings. This article examines the findings of studies relating to amelogenin in the treatment of hard-to-heal wounds. <\/jats:p>","DOI":"10.12968\/bjon.2009.18.sup2.40778","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T14:24:40Z","timestamp":1400855080000},"page":"S22-S29","source":"Crossref","is-referenced-by-count":17,"title":["The use of amelogenin protein in the treatment of hard-to-heal wounds"],"prefix":"10.12968","volume":"18","author":[{"given":"Paul","family":"Chadwick","sequence":"first","affiliation":[{"name":"Salford PCT, Podiatry and Foot Health, Hope Hospital, Salford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Acton","sequence":"additional","affiliation":[{"name":"Surgical Directorate, Queen Elizabeth Hospital NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"p_52","volume-title":"European Wound Management Association Conference","author":"Acton"},{"key":"p_53","first-page":"20","volume":"1","author":"Anderson I","year":"2006","journal-title":"Wound Essentials"},{"key":"p_54","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16353-8"},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"p_56","volume-title":"FDA: Diabetic Foot Ulcer Gel Regranex to Carry Cancer Warning. Available at: http:\/\/www.efluxmedia.com\/news_FDA_Diabetic_Foot_ Ulcer_Gel_Regranex_to_Carry_Cancer_Warning_18691.html (accessed 11\/3\/09)","author":"Boyd A","year":"2008"},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v33.i6.10"},{"key":"p_58","volume-title":"Barbanera S (2007)","author":"Dini V"},{"key":"p_59","volume-title":"Position Document: Understanding Compression Therapy","author":"EWMA","year":"2003"},{"key":"p_60","volume-title":"An Evaluation of a Matrix Replacement Treatment in Intractable Wounds","author":"Hampton S","year":"2007"},{"key":"p_61","volume-title":"An Update on the Norwegian Experience. (Poster) European Wound Management Association Conference","author":"Huldt-Nystrom T"},{"key":"p_62","first-page":"1","volume":"4","author":"Huldt-Nystrom T","year":"2008","journal-title":"Wounds UK"},{"key":"p_63","first-page":"7","volume":"39","author":"Lithner F","year":"1992","journal-title":"IDF Bull"},{"key":"p_64","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2005.130303.x"},{"key":"p_65","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05222.x"},{"key":"p_66","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.12.005"},{"key":"p_67","volume-title":"Glasgow","author":"Meuleneire F","year":"2007"},{"key":"p_68","volume-title":"Diabetes in America","author":"National Diabetes Data Group","year":"1995","edition":"2"},{"key":"p_69","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199805)15:5<412::AID-DIA584>3.0.CO;2-1"},{"key":"p_70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00311.x"},{"key":"p_71","first-page":"58","volume":"3","author":"Rippon M","year":"2007","journal-title":"Wounds UK"},{"key":"p_72","volume-title":"Prague","author":"Romanelli M","year":"2006"},{"key":"p_73","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2008.17.1.27916"},{"key":"p_74","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1998.7.1.47"},{"key":"p_75","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"p_76","first-page":"92","volume":"2","author":"Soon K","year":"2006","journal-title":"Wounds UK"},{"key":"p_77","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2007.16.5.27043"},{"key":"p_78","volume-title":"Glasgow, UK","author":"Vowden K","year":"2007"},{"key":"p_79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00117.x"},{"key":"p_80","volume-title":"3rd Congress of the World Union of World Healing Societies","author":"White"}],"container-title":["British Journal of Nursing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/bjon.2009.18.Sup2.40778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:33:01Z","timestamp":1653352381000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/bjon.2009.18.Sup2.40778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,26]]},"references-count":29,"journal-issue":{"issue":"Sup2","published-print":{"date-parts":[[2009,3,26]]}},"alternative-id":["10.12968\/bjon.2009.18.Sup2.40778"],"URL":"https:\/\/doi.org\/10.12968\/bjon.2009.18.sup2.40778","relation":{},"ISSN":["0966-0461","2052-2819"],"issn-type":[{"value":"0966-0461","type":"print"},{"value":"2052-2819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,26]]}}}