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Children with the severe phenotype show developmental delay and changes in behaviour patterns at about 18 months to 4 years of age. To varying degrees, patients with the severe form manifest behavioural disorders such as hyperactivity, aggression, impulsivity, anxiety and sleep disturbances. Medications, such as antipsychotics, benzodiazepines and anticonvulsants, have been tried with varying degrees of success. Behavioural management strategies may be a worthwhile approach, although published data are lacking. For sleep disturbances, behavioural modification plus melatonin or benzodiazepine may be effective treatments. <\/jats:p>","DOI":"10.12968\/bjon.2016.25.1.22","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T14:26:27Z","timestamp":1452867987000},"page":"22-30","source":"Crossref","is-referenced-by-count":25,"title":["Management of the behavioural manifestations of Hunter syndrome"],"prefix":"10.12968","volume":"25","author":[{"given":"Jane","family":"Roberts","sequence":"first","affiliation":[{"name":"Clinical Nurse Specialist, Manchester Children's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Stewart","sequence":"additional","affiliation":[{"name":"Clinical Nurse Specialist, Birmingham Children's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shauna","family":"Kearney","sequence":"additional","affiliation":[{"name":"Lead Paediatric Neuropsychologist, Birmingham Children's hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.7.2134"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.1.77"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1703-y"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.69.3.403"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-1967-x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9572-0"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.065482"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.019"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1274"},{"issue":"1","key":"B10","first-page":"CD005040","author":"Jesner OS","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-009-1119-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.12.010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02680.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1350"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker394"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000232477.37660.fb"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0999"},{"key":"B18","author":"Muenzer J","year":"2015","journal-title":"Genet Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-013-9665-4"},{"key":"B20","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Neufeld EF","year":"2001","edition":"8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2009.10.008"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-72"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00212.x"},{"key":"B24","volume-title":"Vineland Adaptive Behavior Scales (Vineland\u2122-II)","author":"Sparrow SS","year":"2005"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1997)10:5<361::AID-HUMU5>3.0.CO;2-I"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0635-4"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31817701e6"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/02699050701482470"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.1981.tb00838.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1983.tb13794.x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.6.408"}],"container-title":["British Journal of Nursing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/bjon.2016.25.1.22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T15:36:02Z","timestamp":1653406562000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/bjon.2016.25.1.22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,14]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,14]]}},"alternative-id":["10.12968\/bjon.2016.25.1.22"],"URL":"https:\/\/doi.org\/10.12968\/bjon.2016.25.1.22","relation":{},"ISSN":["0966-0461","2052-2819"],"issn-type":[{"value":"0966-0461","type":"print"},{"value":"2052-2819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,14]]}}}