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Lifestyle modification and alteration of aggravating factors, the use of simple laxatives and, when essential, the addition of newer laxatives or opioid antagonists (naloxone, naloxegol or methylnaltrexone) can be used to treat OIC. This review discusses the recent literature regarding the management of OIC and provides a rational approach to assessing and managing constipation in individuals receiving opioids.<\/jats:p>","DOI":"10.12968\/bjon.2016.25.10.s4","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T15:43:05Z","timestamp":1464363785000},"page":"S4-S11","source":"Crossref","is-referenced-by-count":45,"title":["Management of opioid-induced constipation"],"prefix":"10.12968","volume":"25","author":[{"given":"David","family":"Prichard","sequence":"first","affiliation":[{"name":"Senior Associate Consultant, Division of Gastroenterology, Mayo Clinic Health System La Crosse, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Norton","sequence":"additional","affiliation":[{"name":"Professor of Clinical Nursing Practice Research, Florence Nightingale Foundation, King's College London, 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