{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T03:52:09Z","timestamp":1676951529158},"reference-count":0,"publisher":"Mark Allen Group","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent Update"],"published-print":{"date-parts":[[2006,10,2]]},"abstract":"<jats:p> It is almost a decade since the recognition of the emergence of a new infectious disease termed variant Creutzfeldt-Jakob disease (vCJD) caused by prions (PrP<jats:sup>TSE<\/jats:sup>), abnormal variants of a normal human cell surface protein (PrP). This disease has a number of similarities to other forms of CJD - lethal disorders characterized by a prolonged incubation period, and progressive mental deterioration. In relation to oral tissues, PrP<jats:sup>TSE<\/jats:sup> have been found in neural, gingival, pulpal, lingual, lymphoreticular and salivary gland tissue in animal models. In both sporadic and variant CJD, PrP<jats:sup>TSE<\/jats:sup> is detectable in the trigeminal ganglion and, in vCJD, in lymphoreticular tissues, but infectivity has not been tested in other human oral tissues. <\/jats:p>","DOI":"10.12968\/denu.2006.33.8.454","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T10:13:39Z","timestamp":1501582419000},"page":"454-460","source":"Crossref","is-referenced-by-count":1,"title":["CJD: Update for Dental Staff"],"prefix":"10.12968","volume":"33","author":[{"given":"Crispian","family":"Scully","sequence":"first","affiliation":[{"name":"Eastman Dental Institute, University of London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J","family":"Smith","sequence":"additional","affiliation":[{"name":"Dental School, University of Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bagg","sequence":"additional","affiliation":[{"name":"Dental School, University of Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","container-title":["Dental Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/denu.2006.33.8.454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T18:49:50Z","timestamp":1653418190000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/denu.2006.33.8.454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,2]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,10,2]]}},"alternative-id":["10.12968\/denu.2006.33.8.454"],"URL":"https:\/\/doi.org\/10.12968\/denu.2006.33.8.454","relation":{},"ISSN":["0305-5000","2515-589X"],"issn-type":[{"value":"0305-5000","type":"print"},{"value":"2515-589X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,2]]}}}