{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:29:20Z","timestamp":1759177760178},"reference-count":0,"publisher":"Mark Allen Group","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent Update"],"published-print":{"date-parts":[[2007,10,2]]},"abstract":"<jats:p> Plaque bacteria are the primary initiators of periodontal disease in susceptible persons and therapy is largely based on mechanical bacterial biofilm disruption. Patients' response to periodontal treatment is unpredictable and periodontal stability is not always achieved. Locally delivered antimicrobials (LDAs) may be used as adjuncts to mechanical therapy in treatment of recalcitrant deep (&gt; 5mm), active, non-responding sites, providing the patient's oral hygiene is adequate. Their use as a monotherapy cannot be justified. The literature reveals that LDAs are safe and that they achieve statistically significant, yet clinically modest, gains in clinical attachment and reductions in pocket depths. <\/jats:p>","DOI":"10.12968\/denu.2007.34.8.494","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T10:15:46Z","timestamp":1501582546000},"page":"494-506","source":"Crossref","is-referenced-by-count":7,"title":["Locally Delivered Antimicrobials in the Management of Periodontitis: A Critical Review of the Evidence for their Use in Practice"],"prefix":"10.12968","volume":"34","author":[{"given":"Iyad","family":"Hussein","sequence":"first","affiliation":[{"name":"StatExam, Staff Grade in Periodontology\/Clinical Teacher, Dundee Dental Hospital and School, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meena","family":"Ranka","sequence":"additional","affiliation":[{"name":"Senior House Officer, Birmingham Dental Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Senior Lecturer in Periodontology, Dundee Dental Hospital and School, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Davey","sequence":"additional","affiliation":[{"name":"Lecturer in Periodontology, Dundee Dental Hospital and School, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","container-title":["Dental Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/denu.2007.34.8.494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T17:39:28Z","timestamp":1653413968000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/denu.2007.34.8.494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,2]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,10,2]]}},"alternative-id":["10.12968\/denu.2007.34.8.494"],"URL":"https:\/\/doi.org\/10.12968\/denu.2007.34.8.494","relation":{},"ISSN":["0305-5000","2515-589X"],"issn-type":[{"value":"0305-5000","type":"print"},{"value":"2515-589X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,2]]}}}