{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:58:30Z","timestamp":1778151510867,"version":"3.51.4"},"reference-count":18,"publisher":"Mark Allen Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent Update"],"published-print":{"date-parts":[[2015,6,2]]},"abstract":"<jats:p> Most dental professionals will have, or will soon, encounter patients prescribed this novel alternative antiresorptive drug to bisphosphonates, denosumab (Prolia<jats:sup>\u00ae<\/jats:sup>, Xgeva<jats:sup>\u00ae<\/jats:sup>). Denosumab is licensed in the UK for the prevention of osteoporotic fractures in postmenopausal women and the prevention of skeletal-related events (SRE) in adults with bone metastases. The presence of osteonecrosis of the jaw in patients receiving non-bisphosphonate antiresorptives has led to the introduction of the term antiresorptive-related osteonecrosis of the jaw or ARONJ. This paper discusses the basic physiology of bone remodelling, the pharmacology of bisphosphonates and denosumab, and the risk of ARONJ. <\/jats:p><jats:p> CPD\/Clinical Relevance: What is the potential risk of ARONJ arising from dental treatment that we should be advising for our patients? <\/jats:p>","DOI":"10.12968\/denu.2015.42.5.436","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T10:22:21Z","timestamp":1501582941000},"page":"436-440","source":"Crossref","is-referenced-by-count":7,"title":["Denosumab, an alternative to bisphosphonates but also associated with osteonecrosis of the jaw \u2013 what is the risk?"],"prefix":"10.12968","volume":"42","author":[{"given":"Harlene Kaur","family":"Sidhu","sequence":"first","affiliation":[{"name":"The University of Central Lancashire, Lancashire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"B4","first-page":"c85","volume":"78","author":"Troeltzsch M","year":"2012","journal-title":"J Can Dent Assoc"},{"key":"B5","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1002\/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.0.CO;2-L","volume":"88","author":"Rogers MJ","year":"2000","journal-title":"Cancer"},{"key":"B6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s002239900519","volume":"63","author":"Colucci S","year":"1998","journal-title":"Calcif Tissue Int"},{"key":"B7","first-page":"3890","volume":"57","author":"Boissier S","year":"1997","journal-title":"Cancer Res"},{"key":"B8","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1172\/JCI118841","volume":"98","author":"Van der Pluijm G","year":"1996","journal-title":"J Clin Invest"},{"key":"B9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s007740050071","volume":"17","author":"Koshihara Y","year":"1999","journal-title":"J Bone Miner Metab"},{"key":"B10","first-page":"w13624","volume":"142","author":"Lippuner K","year":"2012","journal-title":"Swiss Med Wkly"},{"issue":"2","key":"B11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1308\/rcsfdj.2014.5.2.90","volume":"5","author":"Ruggiero S.","year":"2014","journal-title":"Faculty Dent J"},{"issue":"1","key":"B12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-6632.2010.05768.x","volume":"1218","author":"Ruggiero SL.","journal-title":"Annls NY Acad Sci"},{"issue":"10","key":"B13","doi-asserted-by":"crossref","first-page":"672","DOI":"10.12968\/denu.2011.38.10.672","volume":"38","author":"Arrain Y","year":"2011","journal-title":"Dent Update"},{"key":"B14","author":"SDCEP","year":"2011","journal-title":"Oral Health Management of Patients Prescribed Bisphosphonates"},{"issue":"1","key":"B15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ctrv.2012.07.002","volume":"39","author":"Peddi P","year":"2013","journal-title":"Cancer Treat Rev"},{"issue":"1","key":"B16","first-page":"48","volume":"33","author":"Qiao GL","year":"2013","journal-title":"TUMOR"},{"issue":"2","key":"B17","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ejca.2012.07.016","volume":"49","author":"Ford JA","year":"2013","journal-title":"Eur J Cancer"},{"issue":"2","key":"B18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10147-013-0561-6","volume":"19","author":"Qi WX","year":"2014","journal-title":"Int J Clin Oncol"},{"issue":"9","key":"B19","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/sj.bdj.2014.360","volume":"216","author":"Renton T","year":"2014","journal-title":"Br Dent J"},{"issue":"11","key":"B20","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.14219\/jada.archive.2011.0108","volume":"142","author":"Hellstein JW","year":"2011","journal-title":"J Am Dent Assoc"},{"issue":"2","key":"B21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/157488611795684686","volume":"6","author":"Rejnmark L","year":"2011","journal-title":"Curr Drug Safety"}],"container-title":["Dental Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/denu.2015.42.5.436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T18:38:59Z","timestamp":1653417539000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/denu.2015.42.5.436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,2]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,6,2]]}},"alternative-id":["10.12968\/denu.2015.42.5.436"],"URL":"https:\/\/doi.org\/10.12968\/denu.2015.42.5.436","relation":{},"ISSN":["0305-5000","2515-589X"],"issn-type":[{"value":"0305-5000","type":"print"},{"value":"2515-589X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,2]]}}}