{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:17:09Z","timestamp":1790972229651,"version":"4.1.0"},"reference-count":13,"publisher":"IMR Press","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>A 39-year-old woman presented with headache and drowsiness. Computed tomography scan confirmed aneurysmal subarachnoid haemorrhage with acute hydrocephalus, necessitating insertion of an external ventricular drain. This improved her consciousness level but she remained restless and confused. Cerebral angiography revealed an aneurysm arising at the origin of the posterior communicating artery. On the third day following haemorrhage the aneurysm was successfully treated by endovascular coiling. During this time she was often noticed to be scratching her vulval area as well as the scalp at the site of insertion of the drain. On vaginal speculum examination copious curdy white discharge was seen. A vaginal swab confirmed this to be caused by Candida albicans.<\/jats:p>\n                  <jats:p>\n                    On the eighth day, her condition deteriorated again. She became drowsy with high grade fever, pyrexia, neck stiffness, vomiting and left hemiparesis. On the tenth day she became very ill and toxic with fulminant signs of meningitis-ventriculitis requiring a transfer to the intensive care unit. The CSF showed a high white cell count of 9500\/mm\n                    <jats:sup>3<\/jats:sup>\n                    with 90% neutrophils. No bacterial organisms were detected on direct microscopy but the culture grew Candida albicans. With aggressive antimicrobial therapy using vaginal clotrimazole pessaries, intravenous fluconazole and intraventricular vancomycin, her neurological condition gradually improved over the next 4 weeks. Clinical improvement also correlated with normalization of CSF picture and eradication of Candida on subsequent cultures. Vaginal discharge also gradually diminished and vulval redness subsided. Six weeks later, she was discharged with mild residual left hemiparesis. She did not have any itching or vaginal discharge.\n                  <\/jats:p>","DOI":"10.12968\/hmed.2007.68.5.23337","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T09:44:14Z","timestamp":1400838254000},"page":"274-275","source":"Crossref","is-referenced-by-count":3,"title":["Life-threatening fungal meningitis-ventriculitis secondary to vaginal candidiasis"],"prefix":"10.31083","volume":"68","author":[{"given":"Yashashri K","family":"Choudhari","sequence":"first","affiliation":[{"name":"Lagan Valley Hospital, Lisburn, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishor A","family":"Choudhari","sequence":"additional","affiliation":[{"name":"Regional Neurosciences Unit, Royal Victoria Hospital, Belfast BT12 6BA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1991.tb02829.x"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.634"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999870"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1007\/BF02387644"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1007\/BF02718273"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1080\/00365540310017573"},{"key":"p_7","first-page":"1303","volume":"18","author":"Lai PH","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(97)00105-8"},{"key":"p_9","first-page":"110","volume":"6","author":"Krome J","year":"1997","journal-title":"J South Orthop Assoc"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(97)70292-1"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.49.11.944"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800840322"},{"key":"p_13","volume-title":"J Bone Joint Surg 75-B: 316-17","author":"von Schroeder HP","year":"1993"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hmed.2007.68.5.23337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:18:49Z","timestamp":1770373129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/68\/5\/10.12968\/hmed.2007.68.5.23337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.12968\/hmed.2007.68.5.23337"],"URL":"https:\/\/doi.org\/10.12968\/hmed.2007.68.5.23337","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}