{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:12:44Z","timestamp":1770412364209,"version":"3.49.0"},"reference-count":6,"publisher":"IMR Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>A 64-year-old man presented with proximal lower limb muscle weakness that had ascended over 3 months to involve the upper limb, bulbar and periocular muscles. In addition, he had muscle aches, dry eyes and mouth, with 10 kg of weight loss. He was an ex-smoker of 50 pack-years.<\/jats:p>\n                  <jats:p>On examination, he had mild dysarthria, bilateral ptosis and proximal muscle weakness (MRC power 4\/5) in all limbs that improved transiently after muscle use. All limb tendon reflexes were absent at rest but returned after sustained muscle contraction for 10 seconds.<\/jats:p>\n                  <jats:p>The serum voltage-gated calcium-channel antibody titre was 237 pmol\/litre (normal &lt;45 pmol\/litre). High frequency repetitive nerve stimulation (Figure 1) produced a successive increase in compound muscle action potential amplitude, confirming the diagnosis of Lambert\u2013Eaton myasthenic syndrome. On spiral computed tomography there was a pretracheal mass extending into the right paratracheal region (Figure 2). Tissue biopsy confirmed small cell lung carcinoma.<\/jats:p>","DOI":"10.12968\/hmed.2009.70.3.40574","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T09:46:46Z","timestamp":1400838406000},"page":"168-169","source":"Crossref","is-referenced-by-count":2,"title":["Lambert\u2013Eaton myasthenic syndrome"],"prefix":"10.31083","volume":"70","author":[{"given":"Yi Zhen","family":"Chiang","sequence":"first","affiliation":[{"name":"Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool L7 8XP,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kian Tjon","family":"Tan","sequence":"additional","affiliation":[{"name":"University Hospitals of South Manchester NHS Foundation Trust, Manchester and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian K","family":"Hart","sequence":"additional","affiliation":[{"name":"Walton Centre for Neurology and Neurosurgery, Liverpool"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.24.7636"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506013322203"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000171169.79816.4c"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1383\/medc.32.11.114.53367"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000281663.81079.24"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01476.x"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hmed.2009.70.3.40574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:16:47Z","timestamp":1770373007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/70\/3\/10.12968\/hmed.2009.70.3.40574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.12968\/hmed.2009.70.3.40574"],"URL":"https:\/\/doi.org\/10.12968\/hmed.2009.70.3.40574","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}