{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:03:45Z","timestamp":1770411825725,"version":"3.49.0"},"reference-count":39,"publisher":"IMR Press","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Dupuytren's disease is a common, costly and recurrent health issue. This review compares Clostridum histolyticum collagenase with current operative treatments. Collagenase management is an effective non-surgical alternative associated with lower risks of serious adverse events, but higher incidence of non-serious adverse events.<\/jats:p>","DOI":"10.12968\/hmed.2012.73.8.432","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T08:40:54Z","timestamp":1400834454000},"page":"432-436","source":"Crossref","is-referenced-by-count":5,"title":["<i>Clostridium histolyticum<\/i>\n                    collagenase in the treatment of Dupuytren's contracture"],"prefix":"10.31083","volume":"73","author":[{"given":"Ernest","family":"Azzopardi","sequence":"first","affiliation":[{"name":"Burns Plastic Reconstructive and Aesthetic Surgery, Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea SA6 6NL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean E","family":"Boyce","sequence":"additional","affiliation":[{"name":"Hand and Peripheral Nerve Surgeon in the Hand Surgery Unit, Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea SA6 6NL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000330236"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2007.04.002"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(03)00135-9"},{"key":"B4","first-page":"68","volume":"74","author":"Bobinski R","year":"2009","journal-title":"Chir Narzadow Ruchu Ortop Pol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181f83129"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(94)90075-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/230949900801600120"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(03)00221-3"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsb.2005.07.001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000205819.53215.52"},{"key":"B11","volume-title":"A treatise on dislocations and on fractures of the joints","author":"Cooper A","year":"1823"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410397971"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2011.03.002"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsb.2006.05.005"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(88)90078-2"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(03)00013-5"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-73"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.08.007"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.027425"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0072-968X(71)90010-6"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810866"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01546.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsb.2005.05.004"},{"key":"B26","first-page":"775","volume":"48","author":"Matton G","year":"1982","journal-title":"Acta Orthop Belg"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(64)80043-6"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(96)80195-1"},{"key":"B29","volume-title":"Needle fasciotomy for Dupuytren's contracture","author":"National Institute for Clinical Excellence","year":"2004"},{"key":"B30","volume-title":"Radiation therapy for early Dupuytren's disease.","author":"National Institute for Health and Clinical Excellence","year":"2010"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000101054.80392.88"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000305932.46121.84"},{"key":"B33","first-page":"557","volume":"6","author":"Thomas A","year":"2010","journal-title":"Clostridium histolyticum collagenase in the treatment of Dupuytren disease. Ther Clin Risk Manag"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(84)80018-2"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7538.397"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.91B3.21054"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsb.2006.03.174"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2006.02.021"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.01.003"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1080\/02844310310000662"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2011.05.016"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hmed.2012.73.8.432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:09:28Z","timestamp":1770372568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/73\/8\/10.12968\/hmed.2012.73.8.432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.12968\/hmed.2012.73.8.432"],"URL":"https:\/\/doi.org\/10.12968\/hmed.2012.73.8.432","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}