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The mainstays of management are largely supportive, consisting of fluid management and respiratory support. Pharmacological interventions including nebulized bronchodilators, steroids and antibiotics generally have limited or no evidence of efficacy and are not advised by National Institute of Health and Care Excellence. Antiviral therapeutics remain in development.<\/jats:p>\n                  <jats:p>As treatments are limited, there have been extensive efforts to develop vaccines, mainly targeting respiratory syncytial virus. At present, the only licensed product is a monoclonal antibody for passive immunisation. Its cost restricts its use to those at highest risk. Vaccines for active immunisation of pregnant women and young infants are also being developed.<\/jats:p>","DOI":"10.12968\/hmed.2019.80.5.278","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T13:50:01Z","timestamp":1557150601000},"page":"278-284","source":"Crossref","is-referenced-by-count":19,"title":["Bronchiolitis: an update on management and prophylaxis"],"prefix":"10.31083","volume":"80","author":[{"given":"Konstantinos","family":"Karampatsas","sequence":"first","affiliation":[{"name":"Specialist Registrar in Paediatrics, Paediatric and Adolescent Division, University College Hospitals NHS Foundation Trust, London NW1 2BU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kong","sequence":"additional","affiliation":[{"name":"Specialty Trainee in Paediatrics, Paediatric and Adolescent Division, University College Hospitals NHS Foundation Trust, 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