{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T20:13:17Z","timestamp":1770408797787,"version":"3.49.0"},"reference-count":13,"publisher":"IMR Press","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2021,10,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims\/Background<\/jats:title>\n                    <jats:p>Gastrointestinal bleeding significantly increases morbidity and mortality rates postoperatively in patients undergoing cardiac surgery. The prophylactic prescribing of proton pump inhibitors post-cardiac surgery is currently a class IIa recommendation of the European Association of Cardio-Thoracic Surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective review of patients who underwent cardiac surgery between July and December 2019 in the authors' hospital was carried out, using discharge summaries. New treatment charts were introduced with a pre-printed proton pump inhibitor included in the \u2018regular medication\u2019 section of the treatment chart and two reaudits were performed using the same methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Before the intervention, 47% were prescribed omeprazole postoperatively, compared to 74% (P&lt;0.001) and 66% (P=0.008) in the first and second reaudits respectively. Gastrointestinal bleeding was more common pre-intervention (4% vs 1% respectively; P=0.10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This intervention resulted in a statistically significant improvement in the prescription of postoperative omeprazole and a decrease in gastrointestinal bleeds. However, other risk factors such as diabetes mellitus, arteriosclerosis and procedure urgency may have contributed to the absence of statistical significance in the latter.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12968\/hmed.2021.0339","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T13:48:51Z","timestamp":1633441731000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Prophylactic use of proton pump inhibitors post-cardiac surgery"],"prefix":"10.31083","volume":"82","author":[{"given":"Matthew","family":"Azzopardi","sequence":"first","affiliation":[{"name":"Cardiothoracic Surgery Department, Mater Dei Hospital, Imsida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Paris","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Department, Mater Dei Hospital, Imsida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sladden","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Department, Mater Dei Hospital, Imsida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/121836"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.092129"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.331"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.02.012"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199203000-00004"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5813"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.07.003"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2009.00985.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs019"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx314"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1053\/cr.2000.5849"},{"issue":"1","key":"B13","first-page":"25","volume":"11","author":"Yoshida K","year":"2005","journal-title":"Ann Thorac Cardiovasc Surg"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hmed.2021.0339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:02:28Z","timestamp":1770372148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/82\/10\/10.12968\/hmed.2021.0339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,2]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,2]]}},"alternative-id":["10.12968\/hmed.2021.0339"],"URL":"https:\/\/doi.org\/10.12968\/hmed.2021.0339","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,2]]}}}