{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:29:39Z","timestamp":1792794579480,"version":"4.5.0"},"reference-count":12,"publisher":"IMR Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2025,3,26]]},"abstract":"<jats:p>We describe the case of a 63-year-old man presenting with fevers, hyperferrintinaemia and pancytopaenia. He was known to have psoriatic arthritis, managed with adalimumab and methotrexate. Haemophagocytic lymphohistiocytosis (HLH) was diagnosed, and he was treated with intravenous anakinra whilst searching for an aetiology. Despite previous treatment for latent tuberculosis, he developed changes typical for miliary tuberculosis and was started on antituberculosis therapy; whole genome sequencing later demonstrated isoniazid monoresistance. This case demonstrates both the importance of recognising Mycobacterium tuberculosis as a trigger of HLH, and also the risk of latent tuberculosis treatment failure in the setting of monoresistance.<\/jats:p>","DOI":"10.12968\/hmed.2024.0462","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:10:26Z","timestamp":1741176626000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Disseminated Tuberculosis Driving Secondary Haemophagocytic Lymphohistiocytosis Following Adalimumab and Treatment for Latent Tuberculosis"],"prefix":"10.31083","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5955-4014","authenticated-orcid":false,"given":"Timothy","family":"Seers","sequence":"first","affiliation":[{"name":"The Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Quah","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Whittington Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdad","family":"Noursadeghi","sequence":"additional","affiliation":[{"name":"The Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"North Central London Tuberculosis Hub (South), Whittington Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brown","sequence":"additional","affiliation":[{"name":"The Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"North Central London Tuberculosis Hub (South), Whittington Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David AJ","family":"Moore","sequence":"additional","affiliation":[{"name":"The Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"North Central London Tuberculosis Hub (South), Whittington Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica J","family":"Manson","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102143"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30695-4"},{"key":"B3","first-page":"e51","volume":"6","author":"Cox MF","year":"2024","journal-title":"Rheumatology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.118935"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12165366"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1405427"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad697"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.11.018"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4103\/0970-2113.168100"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028510"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000797"},{"key":"B12","volume-title":"WHO treatment guidelines for isoniazid-resistant tuberculosis: supplement to the WHO treatment guidelines for drug-resistant tuberculosis","author":"World Health Organization.","year":"2018"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hmed.2024.0462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:59:40Z","timestamp":1770371980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/86\/3\/10.12968\/hmed.2024.0462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,26]]}},"alternative-id":["10.12968\/hmed.2024.0462"],"URL":"https:\/\/doi.org\/10.12968\/hmed.2024.0462","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]}}}