{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T20:38:13Z","timestamp":1770410293106,"version":"3.49.0"},"reference-count":13,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2025,2,25]]},"abstract":"<jats:p>Aims\/Background Improved life expectancy has led to an increased recognition of kidney dysfunction as a common complication in adults with Duchenne muscular dystrophy (DMD). However, data on renal impairment with Becker muscular dystrophy (BMD) especially in pediatric populations, and remains scarce.<\/jats:p>\n                  <jats:p>Case Presentation We present the case of a 5-year-old male with a two-month history of foamy urine. Laboratory investigations revealed nephrotic-range proteinuria and elevated serum creatine kinase (CK) levels. A subsequent muscle biopsy and genetic analysis confirmed the diagnosis of BMD.<\/jats:p>\n                  <jats:p>Results The patient accepted oral deflazacort for two months. Surprisingly, this targeted treatment at BMD not only led to a reduction in CK levels, but also resolved proteinuria during the two-year follow-up.<\/jats:p>\n                  <jats:p>Conclusion This clinical presentation of nephrotic-range proteinuria in pediatric BMD patients is novel and highlights a rare renal manifestation. Chronic kidney impairment in pediatric BMD warrants attention, and the role of kidney biopsy in characterizing DMD\/BMD-associated nephropathy should be explored. Given the lifelong and heterogeneous nature of BMD, multicenter study and long-term follow-up are required to better understand the progression, underlying mechanisms, and clinical outcomes of renal complications in these patients.<\/jats:p>","DOI":"10.12968\/hmed.2024.0569","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T03:35:11Z","timestamp":1739244911000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Becker Muscular Dystrophy and Nephrotic-Range Proteinuria: Chance or True Association?"],"prefix":"10.31083","volume":"86","author":[{"given":"Qunlan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University), Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University), Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaona","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University), Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University), Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-019-04454-w"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2015.01.005"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-024-00858-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5461-0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/path.5704"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-020-04587-3"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05499-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.04.019"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11837-5"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26757"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.688246"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000739"},{"key":"B13","first-page":"425","volume":"38","author":"Zhong X","year":"2021","journal-title":"Chinese Journal of Medical Genetics"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hmed.2024.0569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:59:36Z","timestamp":1770371976000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/86\/2\/10.12968\/hmed.2024.0569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,25]]}},"alternative-id":["10.12968\/hmed.2024.0569"],"URL":"https:\/\/doi.org\/10.12968\/hmed.2024.0569","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]}}}