{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T20:38:13Z","timestamp":1770410293084,"version":"3.49.0"},"reference-count":19,"publisher":"IMR Press","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:p>Aims\/Background Patients receiving kidney transplant experience immunosuppression, which increases the risk of bacterial, viral, fungal, and parasitic infections. Q fever is a potentially fatal infectious disease that affects immunocompromised renal transplant recipients and has implications in terms of severe consequences for the donor's kidney.<\/jats:p>\n                  <jats:p>Case Presentation A patient with acute Q fever infection following kidney transplantation was admitted to the Tsinghua Changgung Hospital in Beijing, China, in March 2021. Next-generation sequencing (NGS) was used to diagnose Q fever in the patient. Based on the patient's blood test, we detected Rickettsia, the causative agent of Q fever and a zoonotic disease that can manifest in acute or chronic forms in humans. Comprehensive data on clinical symptoms, blood tests, chest computed tomography (CT), NGS, Immunoglobulin G (IgG) antibody titer, and therapeutic efficacy associated with Q fever infection following renal transplantation in this patient were gathered.<\/jats:p>\n                  <jats:p>Conclusion This is the first reported case of acute Q fever occurring in a Chinese renal transplant recipient detected using metagenomic NGS. This case underscores the need to consider acute Q fever as a possible differential diagnosis in kidney transplant recipients with fever of unknown origin.<\/jats:p>","DOI":"10.12968\/hmed.2024.0604","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T03:48:59Z","timestamp":1737085739000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["Acute Q Fever after Kidney Transplantation: A Case Report"],"prefix":"10.31083","volume":"86","author":[{"given":"Junjie","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Organ Transplant Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenwang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-6505","authenticated-orcid":false,"given":"Junsheng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Organ Transplant Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruohan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Immunity, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.1441"},{"key":"B2","first-page":"1","volume":"62","author":"Anderson A","year":"2013","journal-title":"MMWR. Recommendations and Reports: Morbidity and Mortality Weekly Report. Recommendations and Reports"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-413"},{"key":"B4","first-page":"20407","volume":"18","author":"Georgiev M","year":"2013","journal-title":"Euro Surveillance: Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.03.022"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3201\/eid1804.111478"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12023"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32490-0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/15303660260613747"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.1580"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2008.07.008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70135-3"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155884"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70052-9"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S265644"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.301-302.2001"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13699"},{"key":"B18","first-page":"654","volume":"94","author":"Tasci HI.","year":"2023","journal-title":"Annali Italiani di Chirurgia"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.12.014"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hmed.2024.0604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:59:32Z","timestamp":1770371972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/86\/1\/10.12968\/hmed.2024.0604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,24]]}},"alternative-id":["10.12968\/hmed.2024.0604"],"URL":"https:\/\/doi.org\/10.12968\/hmed.2024.0604","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]}}}