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MASLD is now recognized as the hepatic manifestation of the metabolic syndrome and is the most common cause of liver disease in the UK, affecting up to 20% of adults. The incidence of MASLD-related cirrhosis and HCC is expected to rise significantly by 2030, highlighting the need for early diagnosis and treatment. For over two decades, effective medical therapies for MASLD were elusive. However, recent trials of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), thyroid hormone receptor-\u03b2 (THR-\u03b2) agonist resmetirom, and fibroblast growth factor 21 (FGF21) agonists have shown promising results in reversing steatohepatitis and potentially fibrosis. These agents potentially offer new disease-modifying treatment options for MASLD, with GLP-1 RAs particularly effective in achieving weight loss and all drugs showing promising histological benefits in patients with MASH. This review summarizes nomenclature changes, provides an update on the UK\u2019s SLD burden, with a particular focus on MASLD and MASH, and discusses new therapeutic strategies for managing this complex and increasingly prevalent condition.<\/jats:p>","DOI":"10.12968\/hmed.2024.0655","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T09:51:31Z","timestamp":1755683491000},"page":"1-18","source":"Crossref","is-referenced-by-count":4,"title":["New Names, New Drugs, Better Outcomes in Steatotic Liver Disease"],"prefix":"10.31083","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-6699","authenticated-orcid":false,"given":"Matthew","family":"Peverelle","sequence":"first","affiliation":[{"name":"Institute of Liver Studies, King\u2019s College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1342-2275","authenticated-orcid":false,"given":"Mzamo","family":"Mbelle","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King\u2019s College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9547-2809","authenticated-orcid":false,"given":"Deepak","family":"Joshi","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King\u2019s College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14271"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30419-4"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.08.002"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.04.003"},{"key":"B5","first-page":"E3451","volume":"113","author":"Alonso-Merino E","year":"2016","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00803-X"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.10.024"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.006"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100232"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265153"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2022-000998"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-023-01346-w"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101351"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.036"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15673"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03351-5"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00443-0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-049767"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3278"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12134"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.06.023"},{"key":"B25","first-page":"511","volume":"8","author":"Loomba R","year":"2023","journal-title":". 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