{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:53:32Z","timestamp":1789192412897,"version":"build-2803163510"},"reference-count":50,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2025,2,25]]},"abstract":"<jats:p>Aims\/Background The classification of polypoidal choroidal vasculopathy (PCV) as a subtype of neovascular age-related macular degeneration (nAMD) remained an ongoing controversy. This meta-analysis examines the efficacy of intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents in nAMD patients with or without PCV.<\/jats:p>\n                  <jats:p>Methods A systematic search was conducted in four databases, including PubMed, EMBASE, MEDLINE, and Cochrane Library, from their inception to 1 July 2023. The outcome measure was the change in best-corrected visual acuity (BCVA) and center retinal thickness (CRT) from the baseline to different follow-up durations. Furthermore, sensitivity analysis was performed when significant heterogeneity was detected.<\/jats:p>\n                  <jats:p>Results This meta-analysis included sixteen studies involving 6679 patients, comprising 5070 non-PCV and 1609 PCV cases. The findings revealed that the improvement in BCVA at 6-month follow-up (mean difference (MD) = 0.05; 95% confidence interval (CI), 0.02 to 0.07; p = 0.0001) and the reduction in CRT at 3-month follow-up duration (MD = 10.29; 95% CI, 0.93 to 19.66; p = 0.03) were significantly greater in the PCV group compared to the non-PCV group.<\/jats:p>\n                  <jats:p>Conclusion This meta-analysis indicates that PCV may exhibit better short-term efficacy in response to anti-VEGF therapy than non-PCV.<\/jats:p>\n                  <jats:p>Systematic Review Registration PROSPERO ( CRD42023445591 ).<\/jats:p>","DOI":"10.12968\/hmed.2024.0673","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T04:47:26Z","timestamp":1739162846000},"page":"1-22","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Intravitreal Anti-VEGF Agents in Neovascular Age-Related Macular Degeneration Patients with or without Polypoidal Choroidal Vasculopathy: A 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