{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T20:10:30Z","timestamp":1770408630267,"version":"3.49.0"},"reference-count":42,"publisher":"IMR Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2025,3,26]]},"abstract":"<jats:p>Arrhythmogenic cardiomyopathy (ACM) is a genetically inherited cardiomyopathy characterised by the fibro-fatty replacement of the myocardium. Patients can present with symptoms of arrhythmia or heart failure; it is a common cause of sudden cardiac arrest and death in young adults. Originally considered as right ventricular arrhythmogenic cardiomyopathy or dysplasia, this terminology has been updated to include left-dominant and biventricular phenotypes. We report a case of a 41-year-old man who presented with an out-of-hospital cardiac arrest due to ventricular arrhythmia as a first presentation. The patient underwent cardiac magnetic resonance imaging, which revealed severe left ventricular (LV) dysfunction with LV fibro-fatty infiltration and a ring-like subepicardial and mid-wall late gadolinium enhancement in the LV. Genetic sequencing identified a pathogenic desmoplakin gene variant. A diagnosis of left-dominant ACM (ALVC) was made based on his presentation, imaging, and genetic findings. Guideline-directed medical therapy with a beta-blocker and an angiotensin-converting enzyme inhibitor was initiated in the first instance. An implantable cardioverter-defibrillator was inserted for secondary prevention. This report highlights the presentation, current diagnostic criteria with a particular focus on ALVC, and the importance of the multimodality approach in the recognition and management of patients with ACM.<\/jats:p>","DOI":"10.12968\/hmed.2024.0674","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:10:26Z","timestamp":1741176626000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Left-Dominant Arrhythmogenic Cardiomyopathy Presenting with Cardiac Arrest"],"prefix":"10.31083","volume":"86","author":[{"given":"Simran","family":"Piya","sequence":"first","affiliation":[{"name":"Department of Cardiology, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Queen Elizabeth University Hospital, Glasgow, UK"},{"name":"School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline J","family":"Coats","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Queen Elizabeth University Hospital, Glasgow, UK"},{"name":"School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Nordin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Queen Elizabeth University Hospital, Glasgow, UK"},{"name":"School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.023"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"B3","first-page":"326","volume":"21","author":"Augusto JB","year":"2020","journal-title":"European Heart Journal. 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