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All agents are effective in treating ulcerative colitis, while Upadactinib is the only SMD for Crohn\u2019s disease. There is growing interest in the use of JAK inhibitors for acute severe colitis. However, safety profiles are distinct from biologics. Clinicians need to be aware of the need for additional lipid monitoring for JAK inhibitors. S1P inhibitors require pre-treatment electrocardiograms to reduce the risk of bradycardia and retinal exams at least in high-risk patients to avoid macular oedema. In this review we highlight the key evidence on efficacy and safety for general hospital physicians.<\/jats:p>","DOI":"10.12968\/hmed.2024.0798","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T06:30:38Z","timestamp":1749105038000},"page":"1-14","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Novel Small Molecule Drugs in the Management of Inflammatory Bowel Disease"],"prefix":"10.31083","volume":"86","author":[{"given":"Nadia","family":"Eden","sequence":"first","affiliation":[{"name":"Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Gaunt","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Ming San","family":"Ong","sequence":"additional","affiliation":[{"name":"Leeds 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