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Five interconnected areas of research are examined, addressing critical gaps in our understanding and our response to opioid overdose events. We analyse epidemiological evidence establishing the scope and patterns of opioid-related mortality, explore laboratory-based overdose research, investigate technological solutions for overdose detection through wearable devices, examine emergency alert systems and community-based interventions, and address innovations in overdose prevention, encompassing both current developments in naloxone formulations and emerging technological advances that may shape future interventions. A comprehensive examination describes how recent innovations enable experimental investigation of heroin overdose in the clinical laboratory alongside the testing of wearable sensors to detect overdose, and the development of new formulations of naloxone, which are more tailored for use by a non-medical and non-clinical workforce. Through such approaches, we can examine previously overlooked areas of research and will, in future, be able to detect and intervene more effectively to prevent opioid overdose deaths.<\/jats:p>","DOI":"10.12968\/hmed.2024.0941","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:34:34Z","timestamp":1759995274000},"page":"1-22","source":"Crossref","is-referenced-by-count":3,"title":["Recent Innovations to Detect and Intervene to Prevent Opioid Overdose Deaths"],"prefix":"10.31083","volume":"86","author":[{"given":"John","family":"Strang","sequence":"first","affiliation":[{"name":"National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King\u2019s College London, London, UK"},{"name":"South London and Maudsley NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Appiah-Kusi","sequence":"additional","affiliation":[{"name":"National Addiction Centre, 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