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Pre-operative counselling of patients with clear communication and educational resources helps to educate patients on the negative effects overuse of opioids can have post-operatively. Novel strategies are being investigated to reduce opioid dependence, particularly in the areas of artificial intelligence (AI) and machine learning (ML), which can help predict patients at increased risk of opioid dependence post-operatively and therefore provide personalised treatment to prevent the harmful sequelae.<\/jats:p>","DOI":"10.12968\/hmed.2024.1022","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:10:07Z","timestamp":1751602207000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Mitigating Opioid Dependence in Orthopaedic Surgery: Current Strategies and Future Directions"],"prefix":"10.31083","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5364-8515","authenticated-orcid":false,"given":"Hugo","family":"Humphries","sequence":"first","affiliation":[{"name":"Department of Trauma and Orthopaedic Surgery, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5547-288X","authenticated-orcid":false,"given":"Andreas","family":"Fontalis","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedic Surgery, University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"Division of Surgery and Interventional Science, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-1516","authenticated-orcid":false,"given":"Warran","family":"Wignadasan","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedic Surgery, University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"Division of Surgery and Interventional Science, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6272-0156","authenticated-orcid":false,"given":"Fares S","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedic Surgery, University College London Hospitals NHS Foundation Trust, London, UK"},{"name":"Division of Surgery and Interventional Science, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"B1","first-page":"2351","volume":"13","author":"Aldanyowi SN.","year":"2023","journal-title":"Life (Basel, Switzerland)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000001251"},{"key":"B3","first-page":"35318","volume":"14","author":"Berardino K","year":"2022","journal-title":"Orthopedic Reviews"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.106B6.BJJ-2023-0889.R1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.106B11.BJJ-2024-0453.R1"},{"key":"B6","first-page":"2266751","volume":"7","author":"Darville-Beneby R","year":"2023","journal-title":"Canadian Journal of Pain = Revue Canadienne De La Douleur"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.106B7.BJJ-2024-0136"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.106B12.BJJ-2024-0021.R1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.106B3.BJJ-2023-0827.R1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.105B5.BJJ-2022-1123.R1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.106B8.BJJ-2024-0183.R1"},{"key":"B12","first-page":"495","volume":"96","author":"Helmerhorst GTT","year":"2014","journal-title":"The Journal of Bone and Joint Surgery. 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