{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:14:12Z","timestamp":1791825252937,"version":"4.3.4"},"reference-count":35,"publisher":"IMR Press","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2025,10,25]]},"abstract":"<jats:p>Irritable Bowel Syndrome with Constipation (IBS-C) is a functional gastrointestinal disorder characterised by abdominal pain, bloating, and altered bowel habits. Emerging research highlights the role of colonic microbiota in its pathophysiology, with IBS-C patients often exhibiting dysbiosis marked by reduced beneficial bacteria (Bifidobacterium, Lactobacillus) and increased inflammatory microbes (Enterobacteriaceae, Escherichia coli). Dysbiosis in IBS-C leads to reduced short-chain fatty acid production, impaired gut motility, and altered serotonin signalling, affecting peristalsis and sensitivity. It also increases intestinal permeability, inflammation, and gut-brain axis interactions, worsening pain and gastrointestinal dysfunction. These alterations impact gut motility, serotonin metabolism, and gut-brain axis signalling, contributing to IBS-C symptoms. Despite growing evidence, inconsistencies in study findings highlight the need for standardised research methods. Future studies should focus on long-term microbiota dynamics, targeted therapies, and personalised treatment strategies to improve symptom management and clinical outcomes. This review systematically summarises the changes in gut microbiota connected to IBS-C and provides a reference for future personalised treatment strategies.<\/jats:p>","DOI":"10.12968\/hmed.2025.0184","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:49:56Z","timestamp":1761133796000},"page":"1-11","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Colonic Microbiota in Constipation Predominant Irritable Bowel Syndrome: A Literature Review"],"prefix":"10.31083","volume":"86","author":[{"given":"Yohan Joe","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Medicine, Sofia Medical University, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeshaa","family":"Mirani","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Aintree University Hospital, Liverpool, 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