{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:53:18Z","timestamp":1790207598764,"version":"4.1.0"},"reference-count":26,"publisher":"IMR Press","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Hosp Med"],"published-print":{"date-parts":[[2025,10,25]]},"abstract":"<jats:p>Aims\/Background Acute myeloid leukemia (AML) is a hematologic malignancy that often requires prolonged hospitalization and intensive treatment, leading to substantial psychological distress and impaired quality of life (QoL). The positive psychology\u2013based PERMA (positive emotion, engagement, relationships, meaning, and accomplishment) model encompasses five dimensions and has demonstrated benefits in various chronic diseases, though evidence in AML remains limited. This study aims to investigate the effects of PERMA model\u2013based nursing on psychological well-being and QoL in hospitalized AML patients.<\/jats:p>\n                  <jats:p>Methods We conducted a single-center, retrospective case\u2013control study of 555 AML inpatients admitted between March 2022 and March 2025. Patients received either PERMA model\u2013based nursing (PERMA group) or conventional nursing (control group). Propensity score matching (PSM; 1:1; caliper = 0.2) was applied to balance baseline characteristics, resulting in 242 matched patients (121 per group). Psychological status was assessed using the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS), and QoL was evaluated using the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ\u2011C30).<\/jats:p>\n                  <jats:p>Results After matching, baseline characteristics were comparable across the two groups. In the control group, SAS scores increased significantly (p = 0.001) while SDS scores showed a slight decrease. Scores of global health status-quality of life (GHS-QoL), physical functioning (PF), emotional functioning (EF), and social functioning (SF) declined markedly (all p &lt; 0.001); nausea\/vomiting (NV) and appetite loss (AP) increased, diarrhea (DI) decreased, and financial difficulties (FI) increased significantly. In the PERMA group, SAS and SDS scores decreased significantly (both p &lt; 0.001), PF declined (p &lt; 0.001), role functioning (RF) improved (p = 0.024), while fatigue (FA), NV, AP, and FI all increased significantly. At discharge, the PERMA group recorded significantly lower SAS and SDS scores and higher GHS-QoL, EF, and SF scores than the control group (p &lt; 0.01).<\/jats:p>\n                  <jats:p>Conclusion PERMA model\u2013based nursing significantly alleviated anxiety and depression and improved key QoL domains in hospitalized AML patients. This structured, low-cost intervention is feasible in clinical practice and merits further validation in multicenter prospective studies.<\/jats:p>","DOI":"10.12968\/hmed.2025.0767","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:17:14Z","timestamp":1761301034000},"page":"1-16","source":"Crossref","is-referenced-by-count":2,"title":["PERMA Model-Based Nursing Improves Psychological Well-Being and Quality of Life in Hospitalized Patients With Acute Myeloid Leukemia: A Propensity Score\u2013Matched Retrospective Study"],"prefix":"10.31083","volume":"86","author":[{"given":"Yuniang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Hematology, Ganzhou People\u2019s Hospital, Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ganzhou People\u2019s Hospital, Ganzhou, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.24.18_suppl.6565"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017314"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-025-01403-7"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/00912174251341978"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00439229"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9788122"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2025.1498078"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq726"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.34_suppl.154"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V112.11.1949.1949"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.139"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay0214"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000001140"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01109"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.20593"},{"key":"B18","first-page":"728","volume":"50","author":"Tu M","year":"2021","journal-title":"Iranian Journal of Public Health"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1159\/000536152"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01722"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn417"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/jep.70175"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-024-01503-y"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13624-z"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(71)71479-0"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hmed.2025.0767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:00:09Z","timestamp":1770372009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/86\/10\/10.12968\/hmed.2025.0767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,25]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,25]]}},"alternative-id":["10.12968\/hmed.2025.0767"],"URL":"https:\/\/doi.org\/10.12968\/hmed.2025.0767","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,25]]}}}