{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:22:07Z","timestamp":1770744127262,"version":"3.49.0"},"reference-count":7,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hospital Medicine"],"published-print":{"date-parts":[[2000,2]]},"abstract":"<jats:p>The management of acute meningococcal disease (MD) exemplifies what is best and worst about modern paediatric intensive care. The best because, in the face of well-staffed teams with centralized experience, survival has improved dramatically (clinical scoring systems such as the Glasgow Meningococcal Septicaemia Prognostic Score indicate that for the highest risk patients (score &gt;12) the mortality has fallen from 100% (Thomson et al, 1991) to 37% (unpublished data, Peters et al, 2000)). The worst because there are no randomized trial data supporting many widely used interventions. This has caused problems in recent years as enthusiasts for novel therapies suggest that trials are now unethical because of improved outcome (Smith et al, 1997), while across the board outcomes are better than previously.<\/jats:p>","DOI":"10.12968\/hosp.2000.61.2.1877","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T11:35:28Z","timestamp":1400844928000},"page":"80-81","source":"Crossref","is-referenced-by-count":0,"title":["Albumin in meningococcal disease"],"prefix":"10.31083","volume":"61","author":[{"given":"Mark","family":"Peters","sequence":"first","affiliation":[{"name":"Institute of Child Health London WC1N 1EH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7153.235"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01587.x"},{"key":"p_3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1242\/jcs.102.4.821","volume":"102","author":"Klein NJ","year":"1992","journal-title":"J Cell Sci"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.5.384"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050647"},{"key":"p_6","volume-title":"Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans Lancet 350: 1590-3","author":"Smith OP","year":"1997"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199101000-00010"}],"container-title":["Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hosp.2000.61.2.1877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T01:43:02Z","timestamp":1770687782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/61\/2\/10.12968\/hosp.2000.61.2.1877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["10.12968\/hosp.2000.61.2.1877"],"URL":"https:\/\/doi.org\/10.12968\/hosp.2000.61.2.1877","relation":{},"ISSN":["1462-3935","2053-4299"],"issn-type":[{"value":"1462-3935","type":"print"},{"value":"2053-4299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}