{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:28:45Z","timestamp":1770744525751,"version":"3.49.0"},"reference-count":6,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hospital Medicine"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>Aman aged 41 years was referred in 1995 for investigation of longstanding gastrointestinal symptoms. He was found to have an alanine transferase activity of 244 iu\/litre and to be hepatitis C positive, both by antibody testing and polymerase chain reaction. He was human immunodeficiency virus negative. He was later confirmed to have cirrhosis on liver biopsy and was started on interferon-alpha (IFN-a) 3 MU three times weekly. Past medical history included irritable bowel syndrome, appendicectomy and intussuception. His surgery may have been accompanied by blood transfusion. He drank moderately, occasionally smoked marijuana and had a past history of injection drug use. His wife was also known to be hepatitis C positive following multiple blood transfusions. He had a positive family history of thyroid disease. His thyroid function tests before starting IFN-a showed free thyroxine (T4) 15.6 pmol\/litre (normal range 9.6\u201426.5 pmol\/litre) and thyroid-stimulating hormone (TSH) 0.2 mu\/litre (normal range 0.6\u20144.8 mU\/litre). Thyroid antibodies were not measured.<\/jats:p>","DOI":"10.12968\/hosp.2001.62.4.1559","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T11:27:52Z","timestamp":1400844472000},"page":"241-241","source":"Crossref","is-referenced-by-count":1,"title":["Thyrotoxicosis induced by alpha interferon therapy for hepatitis C"],"prefix":"10.31083","volume":"62","author":[{"given":"P","family":"De","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Gwent Hospital, Newport NP20 2UB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MC","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Gwent Hospital, Newport NP20 2UB"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.37.246"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92475-4"},{"issue":"3","key":"p_3","first-page":"922","volume":"80","author":"Imagawa A","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1320587"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00259-8"},{"issue":"1","key":"p_6","first-page":"1","volume":"22","author":"Weissel M","year":"1995","journal-title":"Acta Med Austriaca"}],"container-title":["Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hosp.2001.62.4.1559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T01:42:26Z","timestamp":1770687746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/62\/4\/10.12968\/hosp.2001.62.4.1559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.12968\/hosp.2001.62.4.1559"],"URL":"https:\/\/doi.org\/10.12968\/hosp.2001.62.4.1559","relation":{},"ISSN":["1462-3935","2053-4299"],"issn-type":[{"value":"1462-3935","type":"print"},{"value":"2053-4299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}