{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:20:22Z","timestamp":1770744022971,"version":"3.49.0"},"reference-count":7,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hospital Medicine"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>A 33-year-old nulliparous women presented with a 4-week history of a painful vaginal swelling. There had been no relevant medical or gynaecological history of note and she was using the combined oral contraceptive pill (Cilest, Janssen-Cilag, High Wycombe, Bucks) for contraception. On pelvic examination, she had a tender right labial swelling 3\u00d73\u00d72 cm in size. The surrounding area showed no evidence of inflammation.<\/jats:p>\n                  <jats:p>Systemic examination was unremarkable. The clinical diagnosis made was of a right Bartholin cyst. At examination under anaesthesia and excisional biopsy, the lesion appeared to be a cystic, fleshy-looking lesion located on the right labia majora, but was also seen to be extending towards the right ischiorectal fossa. The area was excised and multiple grey fragments (the largest being 110\u00d745\u00d720 mm) were submitted for pathological examination.<\/jats:p>\n                  <jats:p>The lesion was well sampled and consisted of a mass of rather featureless spindled and stellate cells set in a myxoid and fibrillary background. It was highly vascular with considerable areas of red cell spillage into the stroma and some of the larger vessels showed medial hypertrophy. There was evidence of infiltration into adjacent muscle.<\/jats:p>\n                  <jats:p>The other main differential diagnosis considered was angiomyofibroblastoma, but the perivascular condensation and zonality was not seen, nor was the plasma cell or epithelioid component. The tumour was positive for desmin (marker for intermediate cytoskeletal filaments), but negative for smooth muscle actin, S100 and epithelial membrane antigen. The appearance was in keeping with an aggressive angiomyxoma.<\/jats:p>\n                  <jats:p>On confirmation of histology, the patient was sent to the gynaecological oncology team for further follow up, and magnetic resonance imaging was planned for identification of any invasion by tumour in case of recurrence.<\/jats:p>","DOI":"10.12968\/hosp.2004.65.4.12744","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T13:14:30Z","timestamp":1400850870000},"page":"248-249","source":"Crossref","is-referenced-by-count":2,"title":["Aggressive angiomyxoma of the vulva"],"prefix":"10.31083","volume":"65","author":[{"given":"S","family":"Baruah","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Latthe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NR","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SS","family":"Ghataura","sequence":"additional","affiliation":[{"name":"Department of Pathology, City Hospital NHS Trust, Birmingham B18 7QH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80112-X"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<79::AID-CNCR13>3.0.CO;2-4"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199204000-00006"},{"key":"p_4","first-page":"605","volume":"68","author":"Hilgers RD","year":"1986","journal-title":"Obstet Gynaecol"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90058-7"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199709000-00016"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(91)90235-W"}],"container-title":["Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/hosp.2004.65.4.12744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T01:40:13Z","timestamp":1770687613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/65\/4\/10.12968\/hosp.2004.65.4.12744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.12968\/hosp.2004.65.4.12744"],"URL":"https:\/\/doi.org\/10.12968\/hosp.2004.65.4.12744","relation":{},"ISSN":["1462-3935","2053-4299"],"issn-type":[{"value":"1462-3935","type":"print"},{"value":"2053-4299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}