{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:09:48Z","timestamp":1791115788332,"version":"4.1.0"},"reference-count":28,"publisher":"Mark Allen Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> This study aimed to evaluate the safety and performance of a new sustained silver-releasing dressing, Contreet Foam (Coloplast A\/S), in the treatment of moderately to highly exuding chronic venous leg ulcers in which healing is delayed due to the presence of bacteria. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> The clinical performance of Contreet Foam was studied for four weeks in 25 patients with moderately to highly exuding delayed-healing venous leg ulcers. Healing was assessed on a weekly basis with reference to the wound-bed tissue composition, degree of odour and pain, dressing performance and the dressing's effect on the peri-ulcer area. Blood samples were analysed for silver content. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Twenty-three out of 25 patients completed the study. One ulcer healed and no wound infections occurred during the study period. A mean 56% reduction in ulcer area (from 15.6 to 6.9cm<jats:sup>2<\/jats:sup>) was recorded during the four weeks, and there was a mean 25% reduction in granulation tissue from dull to healthy after one week. Wound odour reduced significantly after one week. Mean dressing wear time was 3.1 days, and there were only minimal incidences of leakage. Serum silver levels did not exceed reference values. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Contreet Foam was found to be safe and performed well when used in the treatment of delayed-healing chronic venous leg ulcers, combining effective antibacterial properties with excellent exudate management. <\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest:<\/jats:title><jats:p> This study was supported by Coloplast A\/S, Humleb\u00e6k, Denmark. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2003.12.9.26534","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T15:58:28Z","timestamp":1400860708000},"page":"351-354","source":"Crossref","is-referenced-by-count":76,"title":["Clinical performance of a new silver dressing, Contreet Foam, for chronic exuding venous leg ulcers"],"prefix":"10.12968","volume":"12","author":[{"given":"T.","family":"Karlsmark","sequence":"first","affiliation":[{"name":"Copenhagen Wound Healing Centre, Bispebjerg University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.H.","family":"Agerslev","sequence":"additional","affiliation":[{"name":"Coloplast A\/S, Humleb\u00e6k, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Bendz","sequence":"additional","affiliation":[{"name":"Coloplast A\/S, Humleb\u00e6k, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Coloplast A\/S, Humleb\u00e6k, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Roed-Petersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gentofte County Hospital, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Odense University Hospital, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"p_1","volume-title":"Mouton, R.P., Brumfitt,W., Hamilton Miller, J.M.T. (eds).The Rational Choice of Antibacterial Agents","author":"Lowbury E.J.","year":"1977"},{"key":"p_3","volume-title":"a new topical therapy for Pseudomonas aeruginosa in burns.Arch Surg 1968"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6008.493"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199811000-00013"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2002.11.5.26398"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2002.11.4.26389"},{"key":"p_10","volume-title":"Spain","author":"Larsen K.","year":"2002"},{"key":"p_12","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/clinchem\/37.10.1683","volume":"37","author":"Determination","year":"1991","journal-title":"Clin Chem"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00415.x"},{"key":"p_15","first-page":"446","volume":"42","author":"Wundauflagen","year":"1991","journal-title":"Hautartz"},{"key":"p_17","first-page":"22","volume":"45","author":"Evaluating","year":"2002","journal-title":"Ostomy Wound Manage"},{"key":"p_18","volume-title":"Local environment of chronic wounds under synthetic dressings.Arch Dermatol 1986","author":"Varghese M.C."},{"key":"p_19","first-page":"510","volume":"6","author":"Bale S.","year":"1991","journal-title":"Prof Nurse"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1994.3.3.132"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1038\/193293a0"},{"key":"p_22","volume-title":"Tentative reference values for gold, silver and platinum: literature data and analysis.The Science of the Total Environment 1992","author":"Perelli G."},{"key":"p_23","first-page":"40","volume":"101","author":"Boosalis M.G.","year":"1987","journal-title":"Surgery"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(93)90111-N"},{"key":"p_26","volume-title":"One developed a urinary tract infection and the other a systemic infection","author":"Two"},{"key":"p_28","unstructured":"In the course of the four-week treatment period a mean reduction in ulcer area of 56% from 15.6cm2(range: 3.0-58.1cm2) to 6.9cm2(range: 0.1-38.4cm2) was recorded (Fig 1). All but one ulcer reduced in size (five had regressed to less than 2cm2) and one healed completely after four weeks of treatment with Contreet Foam."},{"key":"p_37","series-title":"Fig 3","volume-title":"Within the first week of the Contreet Foam treatment period, only 20% were malodorous. Severe odour was not reported during the rest of the study","author":"Odour"},{"key":"p_38","unstructured":"At the start of the study 18 patients reported intermittent or constant pain of moderate intensity, and seven had disturbed sleep patterns. Eighty percent reported a stinging or shooting pain of low intensity 0-2 hours after dressing application, which lasted for one to two hours. After four weeks of treatment all patients were able to sleep normally and only 50% reported pain lasting for 30 minutes. Pain intensity was more or less constant throughout the study period."},{"key":"p_40","unstructured":"Abackground level of silver of less than 4nmol\/l was recorded in 19 out of 25 blood samples analysed in the run-up period. Three patients showed an argyraemia of 5.7-9.5nmol\/l, suggesting a previous but unknown exposure to silver. There was no increase in argyraemia after treatment with Contreet Foam."},{"key":"p_44","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(92)90067-5"},{"key":"p_46","first-page":"5","volume":"13","year":"2001","journal-title":"Wounds"},{"key":"p_47","volume-title":"Nanocrystalline silver: where the old and familiar meets a new frontier.Wounds 2001","author":"Ovington L.G."},{"key":"p_49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb01109.x"},{"key":"p_51","doi-asserted-by":"crossref","unstructured":"Metallothioneins: potential therapeutic aids for wound healing in the skin.Wound Repair Regen 2002; 10: 130-132.","DOI":"10.1046\/j.1524-475X.2002.20101.x"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2003.12.9.26534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T02:54:08Z","timestamp":1653360848000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2003.12.9.26534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.12968\/jowc.2003.12.9.26534"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2003.12.9.26534","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}