{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:10:39Z","timestamp":1755925839776},"reference-count":22,"publisher":"Mark Allen Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p> If left undetected or treatment is delayed or inappropriate, diabetic foot ulcers can become limb- and life-threatening. In an attempt to reduce morbidity and mortality rates, efforts are being made, through good glycaemic control and patient\/staff education, to prevent diabetic foot ulcers occurring. When this approach fails, effective diagnostic, prognostic and therapeutic strategies must be employed to reduce the human and financial costs. <\/jats:p>","DOI":"10.12968\/jowc.2005.14.6.26795","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T16:00:35Z","timestamp":1400860835000},"page":"260-263","source":"Crossref","is-referenced-by-count":6,"title":["Antibiotic treatment of infected diabetic foot ulcers"],"prefix":"10.12968","volume":"14","author":[{"given":"S.J.","family":"Sheppard","sequence":"first","affiliation":[{"name":"Rotherham General Hospital NHS Trust, Rotherham, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"p_2","volume-title":"Adv Skin Wound Care 2002"},{"key":"p_5","volume-title":"Arch Intern Med 1999"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2000.9.7.25999"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520330051036"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.Supplement_2.S283"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/6.Supplement_1.S171"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1177\/107110078800900301"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1999.tb01398.x"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00390160058013"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2000.tb04760.x"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/7.2.151"},{"key":"p_19","unstructured":"Approximately 50-60% of serious foot infections are complicated by osteomyelitis.17Many studies do not appear to have sampled the bone either by biopsy or surgical excision\/debridement. Lipsky found that the microbiological cause of osteomyelitis did not correlate with samples from infected soft tissue.17While some believe there may be a risk to undertaking a bone biopsy, such as inducing infection or necrosis, this is the only way of accurately diagnosing osteomyelitis, and thus of improving success rates of culture-guided antibiotic treatment.15,16"},{"key":"p_24","unstructured":"These infections not only present with deep ulceration and purulent discharge but also may have marked necrosis and gangrene. Patients generally present with pyrexia, reflecting the bacteraemia that may progress to full-blown septic shock.10Symptoms can present suddenly and require urgent expert attention. Again, Staphyloccocus aureus and anaerobes such as Bacteroides fragilis are often involved.20With such an acute infection in a structure like the foot, conservative treatment is not appropriate. Surgery is needed to remove the necrotic tissue and pus and relieve the pressure within the compartment.8"},{"key":"p_27","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199602)13:2<156::AID-DIA59>3.0.CO;2-U"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.6.638"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199706)14:6<487::AID-DIA373>3.0.CO;2-Q"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.1999.07.602"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520330042035"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/24.4.643"},{"key":"p_35","first-page":"S48","volume":"18","author":"Van der Meer J.W.M.","year":"1995","journal-title":"Diabet Med"},{"key":"p_36","doi-asserted-by":"publisher","DOI":"10.1179\/joc.1996.8.4.284"},{"key":"p_39","volume-title":"Diabet Care 1982"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2005.14.6.26795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T02:30:05Z","timestamp":1653359405000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2005.14.6.26795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.12968\/jowc.2005.14.6.26795"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2005.14.6.26795","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}