{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:04:25Z","timestamp":1779375865290,"version":"3.53.1"},"reference-count":17,"publisher":"Mark Allen Group","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> A randomised clinical trial (n=42) compared the effectiveness of two approaches to debriding chronic leg ulcers: TenderWet 24, which is designed to support the autolytic degradation process, and Iruxol N (Santyl), an enzymatic treatment claimed to enhance the degradation process. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Patients were randomly assigned to one of the two treatment groups for three weeks. Wounds were evaluated weekly for the amount of eschar\/slough, the area of healthy granulation and the re-epithelialised area. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> During days 1\u201314 slough within the groups was reduced by almost 19% for TenderWet 24 and by 9% for Iruxol N, followed by an increase of 26% and 10% respectively in granulation tissue. These effects were less accentuated during days 7\u201321. There was a further 11% improvement in tissue debridement for the TenderWet 24 group and a relapse (+9.1%) in the Iruxol N group. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Although TenderWet 24 appeared to be more efficient in a few cases, the general efficacy of the two products appeared to be almost the same as no statistically significant superiority of either product was found. <\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest:<\/jats:title><jats:p> This study was sponsored by Paul Hartmann AG, Heidenheim, Germany. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2005.14.7.26813","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T15:59:07Z","timestamp":1400860747000},"page":"320-323","source":"Crossref","is-referenced-by-count":69,"title":["Enzymatic versus autolytic debridement of chronic leg ulcers: a prospective randomised trial"],"prefix":"10.12968","volume":"14","author":[{"given":"M.","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"Dermatology Praxis, Gundelfingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Vanscheidt","sequence":"additional","affiliation":[{"name":"Dermatology Praxis, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Augustin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Clinics of Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kapp","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Paul Hartmann AG, Heidenheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2003.12.4.26490"},{"key":"p_3","first-page":"3","volume":"98","author":"Compression","year":"2002","journal-title":"Nursing Times"},{"key":"p_4","first-page":"41","volume":"144","author":"Ukat A.","year":"2002","journal-title":"MMW Fortschr Med"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70307-7"},{"key":"p_7","first-page":"32","volume":"10","author":"Maklebust J","year":"1997","journal-title":"Adv Wound Care"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-003-0582-6"},{"key":"p_9","first-page":"42","volume":"50","author":"Vanscheidt W.","year":"2004","journal-title":"Ostomy Wound Manage"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1097\/00152193-200404000-00040"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0353.2004.04053.x"},{"key":"p_12","first-page":"34","volume":"49","author":"Paustian C.","year":"2003","journal-title":"Ostomy Wound Manage"},{"key":"p_13","unstructured":"Bradley, M., Cullum, N., Sheldon, T. The neous increase of 25% (TenderWet 24) and 10% (Iruxol N) in granulation tissue (Fig 2). These effects were less accentuated in the second period (days 7-21). There was about an 11% further improvement in tissue debridement in the TenderWet 24 group and a relapse (+9.1%) in the Iruxol N group (Fig 1). Percentage changes of epithelialisation are given in Fig 3."},{"key":"p_25","unstructured":"Iruxol N was easily handled and safe, although dry conditions may be less favourable to the overall outcome in wound cleansing and healing, requiring more effort in dressing changes (extensive and thorough wound irrigation to effectively loosen surface wound debris). In contrast, TenderWet 24 allowed for a `one-step removal' of slough, performed once daily. Its major properties (removal of slough, provision of moisture, absorption and protection) are exerted simultaneously, thus avoiding the potential adverse effects of topical enzymes in wound tissue, while also improving quality of life in patients with chronic venous leg ulcers. \u25a0 debridement of chronic wounds: a systematic review. Health Technol Assess 1999; 3(17, pt 1)."},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1159\/000060629"},{"key":"p_27","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00284-8"},{"key":"p_29","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40021"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00307-6"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-001-0335-3"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2005.14.7.26813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T02:49:03Z","timestamp":1653360543000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2005.14.7.26813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.12968\/jowc.2005.14.7.26813"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2005.14.7.26813","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}