{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:10:20Z","timestamp":1791115820804,"version":"4.1.0"},"reference-count":29,"publisher":"Mark Allen Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate the clinical impact of using a silver-releasing hydroalginate dressing to minimise the risk of local infection in colonised chronic wounds. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> This was a randomised (stratification according to wound type) open-label multicentre comparative two-arm parallel-group study. Thirteen centres recruited 99 patients with either a venous leg ulcer or a pressure ulcer. None of the wounds required systemic antibiotics or were associated with lymphangitis and\/or fever, but at least two of the following criteria had to be present: continuous pain; erythema; oedema; heat; and moderate to high levels of serous exudate. Patients were allocated to receive either a silver-releasing hydroalginate dressing (Silvercel, the test group) or a pure calcium alginate dressing (Algosteril, the control group). Wounds were assessed daily over 14 days to complete a modified ASEPSIS index to evaluate risk of infection, and then weekly for two additional weeks. A global wound severity score and area tracings were recorded weekly. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Fifty-one and 48 patients were randomised in the test and control groups respectively: 28 pressure ulcers and 71 venous leg ulcers. The total mASEPSIS score over 14 days did not differ significantly between groups: 95.4 \u00b1 62.2 and 104.2 \u00b1 72.8 in control and test groups respectively (p=0.791). Of the patients who completed the total four-week study duration, four out of 38 (10.5%) in the control group and none of the 40 in the test group were treated with systemic antibiotics at the final visit (p=0.053). According to the investigators, fewer wounds developed a clinical infection over the four-week follow-up in the test group (33% versus 46%; p=0.223). Overall, the four-week closure rate was statistically greater in the test group (0.32 \u00b1 0.57cm<jats:sup>2<\/jats:sup>\/day versus 0.16 \u00b1 0.40cm<jats:sup>2<\/jats:sup>\/day; p=0.024). Compared with baseline, the absolute decrease in wound severity score at week four was higher in the test group (\u22125.6 \u00b1 3.2 versus \u22124.1 \u00b1 4.3; p=0.063); this was also true of the percentage reduction (\u221232 \u00b1 17% versus \u221223 \u00b1 25%; p=0.034). Poor dressing acceptability and\/or tolerability was noted in five out of 48 patients (10.4%) in the control group and in five out of 51 (9.8%) in the test group. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This study suggests that the use of silver-releasing dressings in the management of wounds at high risk of infection may have a clinically favourable influence on wound prognosis; the dressings also appeared to be well tolerated. However, the evaluation of these advantages in controlled clinical trials is complex and requires potent studies and the development of more specific endpoints than those currently used. <\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest:<\/jats:title><jats:p> This study was funded by a grant from Johnson and Johnson Wound Management. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2005.14.9.26835","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T15:58:47Z","timestamp":1400860727000},"page":"411-419","source":"Crossref","is-referenced-by-count":115,"title":["Evaluation of a silver-releasing hydroalginate dressing in chronic wounds with signs of local infection"],"prefix":"10.12968","volume":"14","author":[{"given":"S.","family":"Meaume","sequence":"first","affiliation":[{"name":"H\u00f4pital Charles Foix, Ivry sur Seine, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Vallet","sequence":"additional","affiliation":[{"name":"CH G\u00e9riatrique du Mont D\u2019Or, Chemin Notre Dame, Albigny sur Sa\u00f4ne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nguyen Morere","sequence":"additional","affiliation":[{"name":"angiologist-Le Plessis Bouchard, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"T\u00e9ot","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lapeyronie, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"p_2","volume-title":"Surg Clin North Am 1980"},{"key":"p_5","first-page":"123","volume":"1","year":"1989","journal-title":"Wounds"},{"key":"p_7","first-page":"14","volume":"46","author":"Preparing","year":"2000","journal-title":"Ostomy Wound Manage"},{"key":"p_8","first-page":"421","volume":"13","author":"Verdu Soriano J.","year":"2004","journal-title":"J Wound Care"},{"key":"p_9","first-page":"109S","volume":"45","author":"Brown D.L.","year":"1999","journal-title":"Ostomy Wound Manage"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1998.7.8.389"},{"key":"p_12","doi-asserted-by":"crossref","unstructured":"evaluating wound infection. Home Healthc Nurse 1999; 17: 3):159-64; quiz 165.","DOI":"10.1097\/00004045-199903000-00008"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.11.s2.1.x"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(86)90089-1"},{"key":"p_16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0749-0690(18)30160-5","volume":"13","author":"Stotts N.A.","year":"1997","journal-title":"Clin Geriatr Med"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.7.701"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/134.1.19"},{"key":"p_20","first-page":"1","volume":"4","author":"O'Meara S.","year":"2000","journal-title":"Health Technol Assess"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2001.01631.x"},{"key":"p_24","first-page":"311","volume":"1","year":"1986","journal-title":"Lancet"},{"key":"p_33","volume-title":"Johnson & Johnson) were used as secondary dressings","author":"Both"},{"key":"p_46","unstructured":"Wound type (leg or pressure ulcer) was balanced between the groups, as was the total number of wounds per subject. There was a non-significant trend of wounds with a longer duration in the test group compared with the control (Tables 4). While global wound areas did not differ significantly between groups for each of the two wound types, the wound surface area of leg ulcers was on average larger in the test group (44.8 - 46.3cm2versus 24.5 + 21.3cm2in the control group)."},{"key":"p_47","unstructured":"Mean wound severity scores at baseline were 16.9 - 3.0 in the control group and 17.5 - 2.5 in the test group (p=0.289). Similarly, there were no significant differences between the groups within the two wound-type strata."},{"key":"p_50","unstructured":"Regardless of the population concerned (ITT or PP) or the calculation procedure (LOVCF or not), no significant between-group differences were detected (Table 6). For the ITT population, the mean mASEPSIS score was 95.4 - 62.2 and 104.2 - 72.8 in the control and test groups respectively (p=0.791). The mASEPSIS score was lower, on average, in the test group for pressure ulcers than in the control group. The reverse was the case for leg ulcers."},{"key":"p_55","unstructured":"Compared with baseline, the absolute reduction in surface area (Table 6) was -8.9 - 16.0cm2in the test group and -4.4 - 11.3cm2in the control group (p=0.117). Expressed in terms of percentage woundarea regression over the four weeks, this was -23.7 - 43.6% and -24.0 - 41.6% in the test and control groups, respectively (p=0.923). While not statistically significant, mean wound areas differed substantially between the groups at inclusion."},{"key":"p_56","unstructured":"To account for this difference, closure rate (CR) was calculated. At each week CR was greater in the test group (Table 7). Overall, the four-week closure rate was statistically greater in the test group (0.32 - 0.57cm2\/day versus 0.16 - 0.40cm2\/day; p=0.024 by ANOVA on log-transformed data)."},{"key":"p_58","volume-title":"the absolute decrease in wound severity score at week 4 was higher in the test group than in the control group (-5.6 - 3.2 versus -4.1 - 4.3","author":"Compared"},{"key":"p_62","first-page":"28","volume":"51","author":"Cutting K.F.","year":"2005","journal-title":"Ostomy Wound Manage"},{"key":"p_63","first-page":"23","volume":"49","author":"Sibbald R.G.","year":"2003","journal-title":"Ostomy Wound Manage"},{"key":"p_65","doi-asserted-by":"publisher","DOI":"10.1159\/000057729"},{"key":"p_66","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.t01-1-10602.x"},{"key":"p_67","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200404000-00004"},{"key":"p_68","first-page":"1S","volume":"50","author":"Ovington L","year":"2004","journal-title":"Ostomy Wound Manage"},{"key":"p_69","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2001.00178.x"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2005.14.9.26835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T02:48:30Z","timestamp":1653360510000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2005.14.9.26835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.12968\/jowc.2005.14.9.26835"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2005.14.9.26835","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}