{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:57:45Z","timestamp":1773777465259,"version":"3.50.1"},"reference-count":41,"publisher":"Mark Allen Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate the efficacy, tolerability and acceptability of a new two-bandage compression system in the local management of venous or mixed aetiology ulcers predominantly of venous origin. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> This was a prospective non-comparative open label phase III clinical study. Forty-two patients were recruited from 12 centres. Inclusion criteria included ulcers with at least 50% granulation tissue, a surface area of 2\u201320cm<jats:sup>2<\/jats:sup>, an ulcer duration of 1\u201324 months, an ankle circumference of less than 28cm, and no history of deep vein thrombosis in the three months before enrolment. The primary endpoint was reduction in ulcer surface area, and secondary endpoints were the evolution of leg oedema and patient comfort. During the six-week follow-up, patients underwent weekly clinical assessments and their ulcer surface area was measured by planimetry and photography every alternate week. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The mean ulcer surface area at inclusion was 7 \u00b1 6cm<jats:sup>2<\/jats:sup>. The mean surface reduction after six weeks was 58.5%, with 24% of the treated wounds healing in a mean time of 25.9 \u00b1 9.46 days. The patients considered that the new compression system had a better effect on quality of life, evaluated by parameters such as pain, heat, itching and general comfort, than the system worn before entry into the study. Patient concordance with the new system was excellent and 86% of leg ulcers improved or healed after six weeks. Local tolerance was considered very good. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This new two-bandage compression system is effective and well accepted by patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest:<\/jats:title><jats:p> This study was sponsored by Laboratoires Urgo, Chen\u00f4ve, France. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2007.16.9.27866","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T15:59:38Z","timestamp":1400860778000},"page":"385-390","source":"Crossref","is-referenced-by-count":38,"title":["Efficacy, safety and acceptability of a new two-layer bandage system for venous leg ulcers"],"prefix":"10.12968","volume":"16","author":[{"given":"J.P","family":"Benigni","sequence":"first","affiliation":[{"name":"Sainte Genevi\u00e8ve des Bois, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Lazareth","sequence":"additional","affiliation":[{"name":"Vascular Unit, Saint Joseph Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Parpex","sequence":"additional","affiliation":[{"name":"Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L","family":"Gerard","sequence":"additional","affiliation":[{"name":"Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Alves","sequence":"additional","affiliation":[{"name":"Autun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Vin","sequence":"additional","affiliation":[{"name":"Neuilly-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Meaume","sequence":"additional","affiliation":[{"name":"Charles Foix Hospital, Ivry-sur-Seine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Senet","sequence":"additional","affiliation":[{"name":"Rothschild Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.A","family":"Allaert","sequence":"additional","affiliation":[{"name":"Cenbiotech, Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sauvadet","sequence":"additional","affiliation":[{"name":"Research and Development, Laboratoires Urgo, Chen\u00f4ve, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Bohbot","sequence":"additional","affiliation":[{"name":"Research and Development, Laboratoires Urgo, Chen\u00f4ve, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2005.14.2.26732"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.104103"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.152"},{"key":"p_6","first-page":"611","volume":"27","year":"2001","journal-title":"Dermatol Surg"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1038\/193293a0"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1038\/197091b0"},{"key":"p_9","volume-title":"Leg ulcers. In","author":"Moffatt C.","year":"2001"},{"key":"p_10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.12968\/jowc.1998.7.3.143","volume":"7","author":"Vowden P","year":"1998","journal-title":"J Wound Care"},{"key":"p_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/120347549800300101","volume":"3","author":"Bello Y.M.","year":"1998","journal-title":"J Cutan Med Surg"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1159\/000018051"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2003.10.014"},{"key":"p_15","first-page":"D000265","volume":"2","author":"Cullum N.","year":"2001","journal-title":"Cochrane Database Syst Rev."},{"key":"p_16","volume-title":"La contention m\u00e9dicale. Collection Abr\u00e9g\u00e9s de M\u00e9decine, edition MASSON","author":"Gardon-Mollard C.","year":"1999"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2000.9.6.25992"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1007\/s005239970002"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1007\/s005230050032"},{"key":"p_24","volume-title":"Wound Repair Regen 2003"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526.30.2.108"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012206.x"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2004.13.1.26563"},{"key":"p_41","unstructured":"At the end of the six-week treatment, the mean surface area was 2.42 - 3.60cm\u00b2 (median 1.05cm2) p<0.0001), compared with 6.97 - 6.43cm\u00b2 (median 4.96cm2) at baseline."},{"key":"p_42","unstructured":"Ten ulcers (24%) healed in a mean of 25.9 - 9.46 days (range 7-41). Their baseline mean surface area was 6.2cm\u00b2 and the mean duration was 6.7 months. The baseline surface area reduced by more than 40% in 32 of the 42 patients in a mean of 18.8 days."},{"key":"p_54","unstructured":"Only three patients (7%) withdrew from the study, all for reasons unrelated to healing or the new system. This is indicative of a high level of patient concordance.15,17-19"},{"key":"p_61","unstructured":"It would be inappropriate to compare the percentage of healed ulcers recorded in this six-week study with the results of studies where the follow-up was 12 weeks. (Six weeks was chosen because the endpoint was not total wound closure.) However, it is worth noting that the mean reduction in ulcer surface area observed after six weeks of treatment (58.51%) is at least comparable with data recorded at six weeks in venous ulcer studies that used other compression therapy systems26-28or compression bandaging plus lipidocolloid primary dressings,29-31where the baseline leg ulcer surface areas and durations were similar. The fact that compression was used in combination with the lipidocolloid dressing in the latter three studies29-31suggests that the primary dressing was not solely responsible for the positive outcomes recorded here."},{"key":"p_62","unstructured":"More than 75% of the leg ulcers in our study showed a 40% or more reduction of their initial surface area in a mean time of 18.8 days. In venous leg ulcers a reduction of 40% of the initial surface area after four weeks of treatment is highly predictive of complete healing at 20-24 weeks.32-34"},{"key":"p_64","unstructured":"Only three topical adverse events were recorded during trial, which is lower than reported elsewhere in the literature.15,17-19"},{"key":"p_65","first-page":"215","volume":"80","author":"Scriven J.M.","year":"1998","journal-title":"Ann R Coll Surg Engl"},{"key":"p_68","volume-title":"Association meeting","author":"Management","year":"2007"},{"key":"p_69","volume-title":"Interface pressure measurements and usability between three compression bandage systems. 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