{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:25:29Z","timestamp":1778631929837,"version":"3.51.4"},"reference-count":47,"publisher":"Mark Allen Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p>To determine the qualitative bacteriological changes that occurred during a four-week treatment period with either manuka honey or a hydrogel dressing. This was the secondary outcome of a randomised controlled trial (RCT) that compared the efficacy of the two treatments in desloughing venous leg ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>This was a prospective open label multicentre RCT with blinded microbiological outcome analysis. Randomisation was conducted via remote telephone. To be included, the wound bed needed to comprise at least 50% slough. Wound swabs were taken at the start of treatment and after four weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In all, 108 patients (35 males, 73 females) aged 24\u201389 years (mean 68) enrolled into the study. Both groups were comparable at baseline. Eighteen patients (17%) were withdrawn due to a wound infection: six in the honey group and 12 in the hydrogel group. Staphylococcus aureus was the most common isolate, being identified in 41 wounds (38%). At baseline, meticillin-resistant Staphylococcus aureus was identified in 16 wounds (10 honey versus six hydrogel). After four weeks 70% (n=7) of the manuka-honey treated wounds versus 16% (n=1) of the hydrogel treated wounds had MRSA eradicated. Pseudomonas aeruginosa was reported in 14% (n=16) of all wounds at baseline. After four weeks 33% (n=2) treated with honey and 50% (n=5) treated with hydrogel had this eliminated. The number of wounds (n=11 at baseline; n=15 at week 4) with \u22653 bacteria species remained constant over the four weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Manuka honey was effective in eradicating MRSA from 70% of chronic venous ulcers. The potential to prevent infection is increased when wounds are desloughed and MRSA is eliminated. This can be beneficial to prevent cross-infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest:<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2008.17.6.29583","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T15:59:59Z","timestamp":1400860799000},"page":"241-247","source":"Crossref","is-referenced-by-count":81,"title":["Bacteriological changes in sloughy venous leg ulcers treated with manuka honey or hydrogel: an RCT"],"prefix":"10.12968","volume":"17","author":[{"given":"G.","family":"Gethin","sequence":"first","affiliation":[{"name":"Research Centre, Faculty of Nursing and Midwifery, Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cowman","sequence":"additional","affiliation":[{"name":"Faculty of Nursing and Midwifery, Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"p_2","first-page":"14","volume":"3","year":"2003","journal-title":"EWMA J"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6485.1855"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1007\/BF03166911"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch075"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013825924765"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02638600"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.1.126"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00379-X"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/24.5.407"},{"key":"p_18","first-page":"3","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"p_19","unstructured":"Himel, H. 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