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Barrier methods of prevention have been extensively tested and licensed, and this article examines the evidence <\/jats:p>","DOI":"10.12968\/jowc.2008.17.9.30939","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T16:00:38Z","timestamp":1400860838000},"page":"405-411","source":"Crossref","is-referenced-by-count":13,"title":["Use of barrier products in the prevention of adhesion formation following surgery"],"prefix":"10.12968","volume":"17","author":[{"given":"B.","family":"Darmas","sequence":"first","affiliation":[{"name":"Department of General Surgery, Royal Gwent Hospital, Newport, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(73)80123-0"},{"key":"p_4","first-page":"60","volume":"72","author":"Intestinal","year":"1990","journal-title":"Ann R Coll Surg"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236862"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.8.1764"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh321"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000225097.60142.68"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.567"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237441"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01394.x"},{"key":"p_19","first-page":"672","volume":"64","year":"1984","journal-title":"Obstet Gynecol"},{"key":"p_20","unstructured":"Preclinical studies using Interceed in laboratory animals indicated that it significantly reduces adhesion formation but its effectiveness is significantly diminished in the presence of blood.40,41This may have special significance in humans when operating on inflamed tissues such as peritonitis, intra-abdominal abscesses or acute diverticulitis as inflamed tissues bleed easily and may reduce the membrane's anti-adhesion effect. Although results obtained from these studies in terms of the adhesion prevention properties of Interceed were encouraging, they were not confirmed by others.42-44It is possible that this apparent ineffectiveness may be related to species differences between animals and humans.38,39The conflicting results of animal tests eventually led to the assessment of Seprafilm and Interceed in clinical studies in humans"},{"key":"p_22","unstructured":"Becker et al45carried out a multicentre prospective randomised double-blind controlled trial (RCT) using Seprafilm in 183 patients undergoing panproctocolectomy and ileal pouch-anal anastomosis (resection of the whole large bowel and rectum and creation of the new rectum using the terminal part of the small bowel). This is a two-stage procedure and anastomosis is normally protected by the formation of loop ileostomy, which is usually reversed within 8-12 weeks. 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