{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:24:36Z","timestamp":1773865476130,"version":"3.50.1"},"reference-count":27,"publisher":"Mark Allen Group","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p> This small case series involved four patients with vascular impairment and multiple comorbidities whose wounds had not responded to standard treatment. Use of this novel therapy help initiate wound healing and improve quality of life <\/jats:p>","DOI":"10.12968\/jowc.2009.18.2.38746","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T15:57:45Z","timestamp":1400860665000},"page":"70-74","source":"Crossref","is-referenced-by-count":7,"title":["Use of a biological extracellular matrix wound therapy to heal complex, chronic wounds"],"prefix":"10.12968","volume":"18","author":[{"given":"T.","family":"Rando","sequence":"first","affiliation":[{"name":"The Royal Melbourne Hospital, Victoria, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01375.x"},{"key":"p_3","first-page":"155","volume":"12","author":"Kantor J.","year":"2000","journal-title":"Wounds"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.01.042"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200506000-00012"},{"key":"p_26","unstructured":"Treatment with the test product was initiated on 20 December 2005. The test product was applied"},{"key":"p_27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2702.2003.00859.x"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00284-8"},{"key":"p_30","first-page":"8","volume":"12","author":"Pressure","year":"1999","journal-title":"Adv Wound Care"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(94)90094-9"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(00)00113-3"},{"key":"p_35","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00156-8"},{"key":"p_36","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(01)00729-9"},{"key":"p_37","unstructured":"After 3-4 weeks the wound began to heal rapidly and its total wound surface area had reduced by 88.5% at week 12 after 11 applications of the test wound product (Figs 1 and 2). No change in pain levels was reported (baseline score 0\/10). Offloading continued with the pressure-reducing ankle foot orthosis boot post-study."},{"key":"p_39","volume-title":"peripheral arterial disease, a history of infection with Stenotrophomonas and previous necrotising fasciitis of the wounded area (January","author":"Patient","year":"2004"},{"key":"p_40","unstructured":"She had a 23.1cm2ulcer on her right Achilles (posterior ankle) with a large amount of haemoserous exudate that was causing maceration and irritation of the peri-wound skin (Fig 3). This fullthickness wound had been present for 2.25 years and had been unsuccessfully treated with a variety of management tools. A wound biopsy showed chronic inflammation and fibrosis. The patient reported mild wound pain (1-2\/10) before treatment at baseline."},{"key":"p_41","volume-title":"The test product was changed weekly","author":"Treatment"},{"key":"p_45","unstructured":"Patient K is a 79-year-old male with peripheral arterial disease, chronic obstructive airways disease, hypertension, chronic atrial fibrillation, gout, chronic obstructive pulmonary disease and chronic renal impairment. He has a history of acute myocardial infarction and smoking, and had had a transmetatarsal amputation in June 2005."},{"key":"p_47","unstructured":"Treatment started on 20 December 2005. The test product, primary and secondary dressings were changed weekly. The wound began to heal rapidly, with the wound surface area reducing by 75% at week 5 (Fig 2). The wound had completely healed at week 12 (Fig 4). Fig 1. Case study 1: patient E's wound at baseline (a) and after 11 weeks of treatment with the test dressing (b)"},{"key":"p_48","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19971215)67:4<478::AID-JCB6>3.0.CO;2-P"},{"key":"p_49","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1879"},{"key":"p_50","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107496"},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03478.x"},{"key":"p_52","first-page":"825","volume":"63","author":"Wysocki A.B.","year":"1990","journal-title":"Lab Invest"},{"key":"p_53","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12359590"},{"key":"p_54","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200610000-00012"},{"key":"p_57","volume-title":"Mr Paul Philcox and Ms Wendy White for their editor","author":"Dr Paul Wraight"},{"key":"p_61","unstructured":"The challenge for clinicians is to identify wounds that are unlikely to heal with standard wound care and initiate a more active or advanced treatment strategy such as the test dressing. Published studies have found that wounds that are not healing adequately (30% or more surface area reduction) within 2-4 weeks of standard wound care are unlikely to heal with continued standard wound care.13-15This suggests that, in such cases at this point, systemic factors should be re-evaluated, a differential diagnosis made and complications such as undiagnosed infection or uncontrolled oedema considered. Once practitioners are confident of the wound diagnosis and standard of care required, and an existing proposal for a wound exudate diagnostic indicator is finalised and made commercially available, a more active treatment strategy, such as use of OASIS Wound Matrix, could be initiated.13"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2009.18.2.38746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:50:23Z","timestamp":1653353423000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2009.18.2.38746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.12968\/jowc.2009.18.2.38746"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2009.18.2.38746","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}