{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T07:00:35Z","timestamp":1761980435404,"version":"build-2065373602"},"reference-count":37,"publisher":"Mark Allen Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate whether the topical application of an amino acid dressing, Vulnamin, aids the management of chronic wounds. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> A total of 160 patients with non-infected cutaneous chronic wounds were recruited. Before treatment, wound size was assessed using digital planimetry. Treatment lasted for a maximum of six weeks. Wound area measurements were repeated two and six weeks after starting treatment. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> There was a significant reduction in the mean wound area after two weeks (7.4 \u00b1 8.7cm<jats:sup>2<\/jats:sup>) and six weeks (4.6 \u00b1 6.3cm<jats:sup>2<\/jats:sup>) of treatment, when compared with baseline (11.2 \u00b1 12.1cm<jats:sup>2<\/jats:sup>, p&lt;0.01). At the final follow up, 23% of patients (n=36) healed and 34% (n=54) achieved a greater than 60% reduction in wound size. Seventy-six per cent (n=120) achieved positive outcomes (defi ned as a greater than 40% reduction in the ulcer size). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Although further investigations on the potential effects of this product on chronic wound healing are required, these data suggest it may promote healing in venous, pressure and diabetic ulcers. <\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest:<\/jats:title><jats:p> This study was sponsored by Professional Dietetics, Milan (Italy). <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2010.19.1.46096","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T15:58:09Z","timestamp":1400860689000},"page":"29-34","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of topical application of amino acids to chronic wounds: a prospective observational study"],"prefix":"10.12968","volume":"19","author":[{"given":"R.","family":"Cassino","sequence":"first","affiliation":[{"name":"Critical Wounds Unit, San Luca Clinic, Pecetto Torinese, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ricci","sequence":"additional","affiliation":[{"name":"Critical Wounds Unit, San Luca Clinic, Pecetto Torinese, Turin, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"volume-title":"Wound bed preparation: science applied to practice","author":"Falanga V.","key":"p_1"},{"volume-title":"MEP","year":"2004","key":"p_2"},{"volume-title":"White, J.R. (ed). Trends in Wound Care","year":"2003","key":"p_4"},{"key":"p_5","unstructured":"British Association for Parenteral and Enteral Nutrition. MUST (Malnutrition Universal Screening Tool) Nutritional Assessment Tool. BAPEN; 2003. Available at: http:\/\/ www.bapen.org.uk\/"},{"volume-title":"NICE","year":"2006","author":"National Institute for Health and Clinical Excellence.","key":"p_6"},{"volume-title":"http:\/\/guidance. nice.org.uk\/CG32","author":"Available","key":"p_7"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.04.012"},{"key":"p_9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.12968\/jowc.1994.3.5.231","volume":"3","author":"Pinchcofsky-Devin G","year":"1994","journal-title":"J Wound Care"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1986.tb03411.x"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7330.160"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2001.10.3.26058"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2009.03.002"},{"volume-title":"Skin barrier: principles of percutaneous absorption","year":"1996","author":"Schaefer H.","key":"p_14"},{"volume-title":"Available at: http:\/\/www.professionaldietetics. it\/products\/vulnamin\/Vulnamin%2 0sterile%20powder.pdf","author":"Vulnamin","key":"p_15"},{"key":"p_17","first-page":"41","volume":"6","author":"Azione","year":"2008","journal-title":"Acta Vulnologica"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)00815-2"},{"key":"p_20","first-page":"111","volume":"3","year":"2005","journal-title":"Acta Vulnologica"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2000.00347.x"},{"edition":"4","volume-title":"Methods in Medical Research","year":"2002","key":"p_24"},{"edition":"2","volume-title":"Statistica non Parametrica","year":"1992","key":"p_26"},{"volume-title":"University of California Press","year":"2009","author":"Statistical Software","key":"p_27"},{"key":"p_29","first-page":"22","volume":"188","year":"2004","journal-title":"Am J Surg"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-9-2"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03478.x"},{"key":"p_32","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107496"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890460053006"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19629.x"},{"key":"p_37","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1879"},{"key":"p_39","first-page":"40","volume":"40","author":"Predictors","year":"1994","journal-title":"Ostomy Wound Manage"},{"key":"p_40","first-page":"625","volume":"36","author":"van Rijswijk L","year":"1993","journal-title":"J Fam Pract"},{"key":"p_41","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00379-X"},{"key":"p_42","first-page":"51","volume":"19","author":"Jones K.R.","year":"2007","journal-title":"Wounds"},{"key":"p_43","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6862.1119"},{"key":"p_44","first-page":"46","volume":"7","author":"Thomas D.R","year":"2006","journal-title":"JAMDA"},{"key":"p_46","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00379-X"},{"key":"p_48","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.12.M795"},{"key":"p_49","first-page":"294","volume":"19","author":"Romanelli M.","year":"2007","journal-title":"Wounds"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2010.19.1.46096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:53:13Z","timestamp":1653353593000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2010.19.1.46096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.12968\/jowc.2010.19.1.46096"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2010.19.1.46096","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"type":"print","value":"0969-0700"},{"type":"electronic","value":"2052-2916"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}