{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:54:12Z","timestamp":1784069652108,"version":"3.55.0"},"reference-count":42,"publisher":"Mark Allen Group","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:title>EObjective<\/jats:title><jats:p> To estimate the efficacy of negative pressure wound therapy (NPWT), on the basis of a systematic review of reported randomised controlled trials (RCTs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p> A systematic literature search for relevant RCTs was carried out. The credibility of the outcome of each study was evaluated using a specially constructed instrument. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> We identified 17 RCTs, of which five had not been included in previous reviews or health technology assessments. For diabetic foot ulcers (seven RCTs), there was consistent evidence of the benefit of NPWT compared with control treatments. For pressure ulcers (three RCTs), results were conflicting. In trials involving mixed wounds (five RCTs), evidence was encouraging but of inadequate quality. Significant complications were not increased. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> There is now sufficient evidence to show that NPWT is safe, and will accelerate healing, to justify its use in the treatment of diabetes-associated chronic leg wounds. There is also evidence, though of poor quality, to suggest that healing of other wounds may also be accelerated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conflict of interest<\/jats:title><jats:p> None. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2010.19.11.79697","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T16:00:09Z","timestamp":1400860809000},"page":"490-495","source":"Crossref","is-referenced-by-count":89,"title":["The clinical effectiveness of negative pressure wound therapy: a systematic review"],"prefix":"10.12968","volume":"19","author":[{"given":"X.","family":"Xie","sequence":"first","affiliation":[{"name":"Technology Assessment Unit"},{"name":"McGill University Health Centre, Montr\u00e9al, Quebec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"McGregor","sequence":"additional","affiliation":[{"name":"Department of Medicine and Chair, Technology Assessment Unit, University Health Centre;"},{"name":"McGill University Health Centre, Montr\u00e9al, Quebec, Canada;"},{"name":"Cardiovascular Division, Department of Medicine, McGill University, Montr\u00e9al, Quebec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dendukuri","sequence":"additional","affiliation":[{"name":"Technology Assessment Unit, University Health Centre;"},{"name":"McGill University Health Centre, Montr\u00e9al, Quebec, Canada;"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montr\u00e9al, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"p_1","volume-title":"35 have drawn attention to the fact that a lack of access to unpublished studies of NPWT raises doubts as to the completeness of the evidence base. In","author":"Peinemann","year":"2008"},{"key":"p_2","volume-title":"Although seven19,20,25-27,30,31 of the 17 studies evaluated here reported partial funding by the manufacturer","author":"Also"},{"key":"p_8","unstructured":"ulcer n (%) of foot ulcer improvement 5 (56) 1 (11) <0.05 armstrong following 77\/85\u2020 n (%) complete healing by 112 days 43 (56) 33 (39) 0.040 b and lavery20\u00a7 diabetic foot median days to >76% granulation (iQr) 42 (40-56) 84 (57-112) 0.002"},{"key":"p_12","volume-title":"21 foot ulcer % change in wound surface area","author":"Il"},{"key":"p_17","unstructured":"vuerstaek chronic 30\/30\u2020** days to healing; median (95% ci) 29 (26-33) 45 (36-54) <0.05 b etal26\u00a7 venous or n (%) healed in 43 days 25 (90) 12 (48) <0.001 \u2020\u2020"},{"key":"p_18","unstructured":"microsangiopathic Wound preparation days; mean (95% ci) 7 (5.7-8.3) 17 (10-24) 0.005 leg ulcer"},{"key":"p_19","unstructured":"braakenburg Wounds 32\/33\u2020 days to healing; median (95% ci) 16 (9-23) 20 (16-24) 0.32 c et al.25\u00a7 37% acute; 63% chronic"},{"key":"p_23","volume-title":"22\u2020) % change in wound","volume":"52"},{"key":"p_24","volume-title":"30\u00a7 chronic wounds","volume":"78","author":"Joseph"},{"key":"p_25","unstructured":"79% due (total: 24\u2020) % change in wound depth -66 -20 <0.001 to pressure"},{"key":"p_26","volume-title":"or one or more authors received research grants from the manufacturer","author":"Wt"},{"key":"p_34","first-page":"261","volume":"200","journal-title":"Wound J"},{"key":"p_35","first-page":"45","volume":"200","journal-title":"J Wound care"},{"key":"p_36","first-page":"233","volume":"200","journal-title":"Wound J"},{"key":"p_37","volume-title":"d.t.,Westerbos, s.J., evans, d. et al.topical negative pressure for treating chronic wounds. cochrane database syst rev 2009","author":"Ubbink","year":"1898"},{"key":"p_64","volume-title":"d.t.,Westerbos, s.J., nelson, e.a.,vermeulen, h.a systematic review of topical negative pressure therapy for acute and chronic wounds. br J surg 2008","author":"Ubbink"},{"key":"p_65","volume-title":"s., maegele, m., de laat, e. et al. negative pressure wound therapy: a vacuum of evidence? arch surg 2008","author":"Gregor"},{"key":"p_66","volume-title":"m., de laat, e.d., spauwen, p., schoonhoven, l. the effectiveness of topical negative pressure in the treatment of pressure ulcers: a literature review. eur J plast surg 2008"},{"key":"p_67","first-page":"5","volume":"200","journal-title":"Wma"},{"key":"p_68","volume-title":"negative pressure Wound therapy:an evidence-based analysis.available from: http:\/\/ www.health.gov.on.ca\/english\/ providers\/program\/mas\/tech\/ reviews\/pdf\/rev_npwt_070106.pdf [accessed september 11","year":"2010"},{"key":"p_69","unstructured":"negative pressure wound therapy 2006. cologne: Germany. http:\/\/ www.iqwig.de\/download\/"},{"key":"p_70","volume-title":"b.J.,atienza, m.G.vacuum-assisted closure effectiveness for chronic wounds therapy (technical report)","author":"Gastelu","year":"2005"},{"key":"p_72","unstructured":"has-sante.fr\/portail\/upload\/docs\/ application\/pdf\/2010-02\/ rapport_traitement_plaies_ pression_negative.pdf [accessed september 11, 2010]."},{"key":"p_75","volume-title":"K.,abbotts, J., downie, s. et al.topical negative pressure therapy for wounds.","year":"2010"},{"key":"p_76","unstructured":"nhshealthquality.org\/nhsqis\/files\/ hta12_JUl10.pdf [accessed october 19, 2010]."},{"key":"p_77","volume-title":"mcGregor, m. negative pressure wound therapy","author":"Xie X.","year":"2010"},{"key":"p_78","volume-title":"canada.available from: http:\/\/www.mcgill.ca\/files\/ tau\/npWt_final.pdf [accessed september 11","author":"montreal:technology assessment Unit of the mcGill University health center","year":"2010"},{"key":"p_79","volume-title":"esp\u00edndola, m., maureira, m. et al. negativepressure wound therapy versus standard wound dressing in the treatment of diabetic foot amputation.a randomised controlled trial. cir esp 2009","author":"\u00falveda G."},{"key":"p_80","doi-asserted-by":"crossref","unstructured":"blume, p.a.,Walters, J., payne, W. etal comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. diabetes care 2008; 31: 4, 631-636.","DOI":"10.2337\/dc07-2196"},{"key":"p_83","doi-asserted-by":"crossref","unstructured":"lancet 2005; 366: 9498,1704-1710. 21 mccallon, s.K., Knight, c.a., valiulus, J.p. et al.vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds. ostomy Wound manage 2000; 46: 8, 28-32, 34.","DOI":"10.1016\/S0140-6736(05)67695-7"},{"key":"p_84","volume-title":"K.r., seabrook, G.r. et al.a prospective randomized evaluation of negative-pressure wound dressings for diabetic foot wounds.ann vasc surg. 2003"},{"key":"p_85","first-page":"264","volume":"200","author":"\u00f6z","journal-title":"Wounds"},{"key":"p_87","volume-title":"randomized controlled trial. 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