{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:14:56Z","timestamp":1773285296121,"version":"3.50.1"},"reference-count":23,"publisher":"Mark Allen Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> To investigate the threshold of transcutaneous oxygen tension (TcPO<jats:sub>2<\/jats:sub>) values in predicting ulcer healing in patients with critical limb ischaemia in a prospective study. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p> 50 patients suffering from critical limb ischaemia with chronic ischemic ulcers or gangrenous toes were enrolled in this study between January and December 2008. Their demographic data and ankle brachial pressure index (ABPI) were collected. Baseline ulcers were measured with a wound measurement system (Visitrak, Smith &amp; Nephew). TcPO<jats:sub>2<\/jats:sub> was measured at rest in the supine position and with 30\u00b0 leg elevation. The patients with infective and ischemic ulcers underwent debridement and gangrenous toes were amputated. Ulcer outcome was classifi ed as either: (1) A healing ulcer, showing good epithelialisation or granulation at both base and edges, or a decrease in ulcer area during the study; or (2) A non-healing ulcer, showing poor granulation tissue formation or a pale base and necrotic edges, or deterioration in an ischaemic ulcer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The mean age of the patients was 67.6 \u00b1 10.8 years. The most common risk factor was hypertension (90%). Mean ABPI was 0.75 \u00b1 0.39. 13 patients (26%) had a TcPO<jats:sub>2<\/jats:sub> of less than 20mmHg, of which none showed any improvement in ulcer healing (p&lt;0.001). 15 patients (30%) had a TcPO<jats:sub>2<\/jats:sub> of more than 40mmHg, of which all progressed to complete ulcer healing (p&lt;0.001). In the borderline group (20\u201340mmHg, 22 patients, 44%), 10 patients (45%) had a TcPO<jats:sub>2<\/jats:sub> drop of &lt;10mmHg with 30\u00b0 leg elevation, of which 8 achieved complete ulcer healing (p&lt;0.001). 12 patients (55%) had a TcPO<jats:sub>2<\/jats:sub> drop of &gt;10mmHg with 30\u00b0 leg elevation, of which 11 showed no ulcer healing (p&lt;0.001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> TcPO<jats:sub>2<\/jats:sub> measurement is an accurate, non-invasive, and good predictor of ischemic ulcer healing, for cut-off TcPO<jats:sub>2<\/jats:sub> values of less than 20mmHg and more than 40mmHg. In addition, the leg elevation method for TcPO<jats:sub>2<\/jats:sub> might provide an important adjunct in the assessment of patients with borderline values. <\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest<\/jats:title><jats:p> None. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2010.19.5.48048","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T12:00:08Z","timestamp":1400846408000},"page":"202-206","source":"Crossref","is-referenced-by-count":75,"title":["Transcutaneous oxygen tension: a useful predictor of ulcer healing in critical limb ischaemia"],"prefix":"10.12968","volume":"19","author":[{"given":"C.","family":"Ruangsetakit","sequence":"first","affiliation":[{"name":"Vascular Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chinsakchai","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mahawongkajit","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Wongwanit","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mutirangura","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.09.024"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.1.147"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70018-8"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S6759"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.12.027"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.4.2.289"},{"key":"p_19","unstructured":"TcPO2values are illustrated in Fig 3, which shows that most patients had values of 11-20mmHg. The outcomes for different groups are presented in Table 3. None of patients with a TcPO2of <20mmHg (group 1) showed signs of ulcer healing, whereas all of the patients with a TcPO2of >40mmHg (group 3) showed a progression towards healing during the study period (p<0.001). In the borderline group (20-40mmHg, group 2), 10 patients had a decrease in TcPO2of <10mmHg with leg elevation (subgroup 1), of whom eight (80%) healed (p<0.001). In contrast, 12 patients had a decrease in TcPO2 of >10mmHg with leg elevation (subgroup 2), and 11 of these (92%) failed to heal (p<0.001)."},{"key":"p_22","unstructured":"Our results suggest that TcPO2values of <20mmHg or >40mmHg when supine, and leg elevation TcPO2values of 20-40mmHg are clinically useful in predicting healing outcomes in patients with critical limb ischaemia."},{"key":"p_29","unstructured":"0 0-10 11-20 21-30 31-40 41-50 51-60"},{"key":"p_33","unstructured":"Based on our data, TcPO2values of <20mmHg and >40mmHg can accurately predict ulcer healing outcomes. Furthermore, we have been able to correctly predict more than 80% of outcomes for patients with TcPO2values of 20-40mmHg (group 2). Although these values have previously been used to assess amputated patients,7they may be applicable to outcomes in patients with critical limb ischaemia, chronic ischaemic ulcers and ulcers following gangrenous toe amputation, as examined here."},{"key":"p_34","unstructured":"When assessing ulcers, we have regarded healthy granulation tissue at the base or edges to be an indication of healing.13In addition, we have evaluated outcomes within 2-4 weeks, which is consistent with Keast et al.11who showed that the percentage decrease in ulcer area (measured with the Visitrak system) during that period was a predictor of healing at 12-24 weeks."},{"key":"p_45","unstructured":"Group 2 (20-40mmHg) 9 13 22"},{"key":"p_49","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(92)90196-F"},{"key":"p_50","first-page":"43","volume":"36","author":"Fife C.E.","year":"2009","journal-title":"Undersea Hyperb Med"},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1007\/BF02001886"},{"key":"p_52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2007.01790.x"},{"key":"p_53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.0123S1.x"},{"key":"p_54","first-page":"41","volume":"35","author":"Shah J.B.","year":"2008","journal-title":"Undersea Hyperb Med"},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7536.285"},{"key":"p_56","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690040093015"},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1136\/jech.42.2.128"},{"key":"p_58","doi-asserted-by":"publisher","DOI":"10.1067\/mva.1987.avs0060147"},{"key":"p_59","first-page":"32","volume":"45","author":"Dormandy J.A.","year":"1995","journal-title":"Rev Prat."}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2010.19.5.48048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T22:36:56Z","timestamp":1653345416000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2010.19.5.48048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.12968\/jowc.2010.19.5.48048"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2010.19.5.48048","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}