{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:58:11Z","timestamp":1782799091067,"version":"3.54.5"},"reference-count":6,"publisher":"Mark Allen Group","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>\u2022 Objective:<\/jats:title><jats:p> To determine the effect of topically applied amelogenin extracellular matrix protein (AEMP) in patients with non-healing venous leg ulcers combined with atrophie blanche. <\/jats:p><\/jats:sec><jats:sec><jats:title>\u2022 Method:<\/jats:title><jats:p> This retrospective case series of patients with non-healing venous leg ulcers with atrophie blanche of the distal proportion of their lower legs, where non-healing was defined as no progress toward healing for 3 months previously, under standard therapy. Patient records were reviewed for associated diseases, wound diagnoses, distal blood pressure, previous treatments and changes in wound area. Patients were treated with AEMP once a week, for a period of 12 weeks, or until full healing. <\/jats:p><\/jats:sec><jats:sec><jats:title>\u2022 Results:<\/jats:title><jats:p> Eleven patient records were reviewed retrospectively. The median age of the patients was 81 years (range 40\u201395 years), with a mean wound size of 4.7 \u00b1 3.5cm<jats:sup>2<\/jats:sup> and median wound duration of 6 months (range 3\u2013444 months). All patients had venous or combined arterial\/venous insufficiency. After 12 weeks' treatment with AEMP, complete healing, defined as 100% re-epithelialisation, was documented in four patients (36%), marked improvement (&gt; 50% epithelialisation) in three patients (54%, 55% and 83% wound closure, respectively), slight improvement in one patient (9.4% wound closure), no change for two patients and worsening in one. AEMP was well tolerated, and no patients reported side effects. <\/jats:p><\/jats:sec><jats:sec><jats:title>\u2022 Conclusion:<\/jats:title><jats:p> The results of this retrospective study suggest that AEMP improves healing in chronic venous leg ulcers combined with atrophie blanche. <\/jats:p><\/jats:sec><jats:sec><jats:title>\u2022 Declaration of interest:<\/jats:title><jats:p> Amelogenin extracellular matrix protein (XelmaR) was provided by M\u00f6lnlycke Health Care, Denmark. There were no external sources of funding for this study and M\u00f6lnlycke Health Care had no role in the study design or data collection. The authors have no conflicts of interest to declare. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2012.21.12.612","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T12:59:38Z","timestamp":1400849978000},"page":"612-614","source":"Crossref","is-referenced-by-count":4,"title":["Effect of amelogenin ECM protein on the healing of chronic leg ulcers with atrophie blanche"],"prefix":"10.12968","volume":"21","author":[{"given":"K.","family":"Fogh","sequence":"first","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.B.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Dam","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","volume-title":"Dermatology","author":"Lin P.","year":"2003"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2009.18.Sup2.40778"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00117.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2007.16.5.27043"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S1846"},{"issue":"1","key":"B7","first-page":"20","volume":"18","author":"Romanelli M.","year":"2008","journal-title":"J Wound Care"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2012.21.12.612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T14:11:56Z","timestamp":1653315116000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2012.21.12.612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":6,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.12968\/jowc.2012.21.12.612"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2012.21.12.612","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}