{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:35:54Z","timestamp":1776108954359,"version":"3.50.1"},"reference-count":25,"publisher":"Mark Allen Group","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate the efficacy of a plant-derived wound dressing, a mixture of hypericum oil (Hypericum perforatum) and neem oil (Azadirachta indica), in scalp wounds with exposed bone. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> A retrospective review was conducted of all patients presenting with scalp wounds with exposed bone following the excision of skin tumours and treated with a plant-derived wound dressings (1 Primary Wound Dressing; Phytoceuticals AG), from January to July 2011. Time to healing, wound size, area of exposed bone, ease of handling, pain and complications were evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Nine consecutive patients were analysed retrospectively. The patients' mean age was 81.2 \u00b1 8.5 years (63\u201390 years), with a mean wound size of 13.2 \u00b1 6.8cm<jats:sup>2<\/jats:sup> (0.4\u201322.6cm<jats:sup>2<\/jats:sup>) and 6.8 \u00b1 6.5cm<jats:sup>2<\/jats:sup> (0.3\u201320.7cm<jats:sup>2<\/jats:sup>) of exposed bone. The time to complete healing by secondary intention was 4\u201320 weeks. A rapid induction of granulation tissue was observed, which covered the entire exposed bone surface in six out of nine cases (67%) after 4 weeks, and showed a reduction in the mean area of exposed bone of 95%. Dressing change was easy and without pain and there were no complications. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This retrospective, non-controlled analysis suggests that ONE is a very simple to use, safe and potentially effective therapy for the treatment of scalp wounds with exposed bone. <\/jats:p><\/jats:sec><jats:sec><jats:title>Declaration of interest:<\/jats:title><jats:p> There were no external sources of funding for this study. The authors have no conflict of interest to declare. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2012.21.5.228","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T12:59:46Z","timestamp":1400849986000},"page":"228-233","source":"Crossref","is-referenced-by-count":26,"title":["Post-surgical scalp wounds with exposed bone treated with a plant-derived wound therapeutic"],"prefix":"10.12968","volume":"21","author":[{"given":"S.","family":"L\u00e4uchli","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hafner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Wehrmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.E.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hunziker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital (Inselspital), Bern, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.01.002"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/hn.1999.v121.a98216"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/193293a0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000237094.58891.fb"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-010-2089-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000154210.60284.C6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2009.05.038"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-009-2355-3"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70209-8"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000180450.21350.3e"},{"issue":"1","key":"B11","first-page":"S141","volume":"129","author":"Schintler M.V.","year":"2004","journal-title":"Zentralbl Chir."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200001000-00030"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01913.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181d08cee"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-005-0929-2"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31820fe354"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200045020-00003"},{"issue":"3","key":"B18","first-page":"357","volume":"34","author":"Koenen W.","year":"2008","journal-title":"Dermatol Surg"},{"issue":"11","key":"B19","first-page":"890","volume":"8","author":"Inhoff O.","year":"2010","journal-title":"J Dtsch Dermatol Ges"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050555"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1977.01370030057010"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2000.00046.x"},{"issue":"12","key":"B23","first-page":"1107","volume":"28","author":"Gohari S.","year":"2002","journal-title":"Dermatol Surg"},{"key":"B24","first-page":"112","volume":"6","author":"Sharman D.","year":"2003","journal-title":"Diabetic Foot"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2010.19.Sup4.48418"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2012.21.5.228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T14:18:42Z","timestamp":1653315522000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2012.21.5.228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.12968\/jowc.2012.21.5.228"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2012.21.5.228","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}