{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:24:46Z","timestamp":1784046286740,"version":"3.55.0"},"reference-count":40,"publisher":"Mark Allen Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2015,10,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Aloe vera is a medicinal plant that has been traditionally used to accelerate wound healing. Olive oil is also a natural product that may contribute to wound healing owing to its antimicrobial and anti-inflammatory effects. The present study aimed to evaluate the effect of an Aloe vera\u2013olive oil (AVO) combination cream on the healing process of chronic wounds. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> In this randomised, double-blind, comparator-controlled, parallel-group trial, patients with chronic wounds were treated with either AVO cream or phenytoin cream as the standard treatment for a period of 30 days. Wound healing was evaluated using Bates-Jensen assessment tool and the severity of pain was assessed using a visual analogue scale (VAS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> After initial assessment, 60 patients with chronic wounds (41 with pressure ulcer, 13 with diabetic wounds and 6 with venous ulcers), were recruited and randomised into 2 groups of 30. After 30 days of treatment, significant improvements in the wound size, depth, and edges; necrotic tissue type and amount; exudate type and amount; colour of wound surroundings; and peripheral tissue oedema score were observed in the AVO cream group (p&lt;0.001). The total score of wound healing showed significant improvement with both AVO (p&lt;0.001) and phenytoin (p&lt;0.01) creams, although AVO was more efficacious (p&lt;0.001). Likewise, although both treatments reduced the initial VAS score, the efficacy of AVO was significantly greater (p&lt;0.001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2015.24.10.459","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T17:47:06Z","timestamp":1445449626000},"page":"459-465","source":"Crossref","is-referenced-by-count":47,"title":["Comparative trial of <i>Aloe vera<\/i>\/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds"],"prefix":"10.12968","volume":"24","author":[{"given":"Y.","family":"Panahi","sequence":"first","affiliation":[{"name":"Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, 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