{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:10:54Z","timestamp":1782810654401,"version":"3.54.5"},"reference-count":16,"publisher":"Mark Allen Group","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Wound Care"],"published-print":{"date-parts":[[2015,11,2]]},"abstract":"Objective:<\/jats:title> The effects of a collagen dressing on hard-to-heal venous leg ulcers (vlUs) were evaluated in this prospective, randomised, controlled study. <\/jats:p><\/jats:sec>Method:<\/jats:title> Patients with hard-to-heal vlU were included and divided into two groups using the block randomisation method. The first group was treated with a collagen and an alginate dressing (group A), and the second group with an alginate dressing alone (group b). both groups also had a short-stretch compression system applied at every dressing change. The dressings were changed twice a week for 12 weeks or until the ulcer was healed. Granulation tissue improvement, wound size, overall dressing performance and dressing comfort were evaluated and recorded. <\/jats:p><\/jats:sec>Results:<\/jats:title> A total of 40 patients completed the study evaluation period. Group A had a 65% increase in granulation tissue compared to 38% in group b. The mean ulcer area was reduced to 45% in group A compared to 20% in group b at 12 weeks. no significant side effects were detected in either group. Patients of both groups were satisfied with their treatment and healing progress. <\/jats:p><\/jats:sec>Conclusion:<\/jats:title> The results of this study showed the effectiveness and safety of a collagen dressing in hard-to-heal vlUs as an adjunctive therapy with compression bandaging. These encouraging results may positively affect the quality of life of patients with chronic wounds. <\/jats:p><\/jats:sec>","DOI":"10.12968\/jowc.2015.24.11.543","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T15:06:49Z","timestamp":1447081609000},"page":"543-547","source":"Crossref","is-referenced-by-count":18,"title":["The use of a collagen matrix in hard-to-heal venous leg ulcers"],"prefix":"10.12968","volume":"24","author":[{"given":"M.","family":"Romanelli","sequence":"first","affiliation":[{"name":"Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mulder","sequence":"additional","affiliation":[{"name":"University of California San Diego, California, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Paggi","sequence":"additional","affiliation":[{"name":"Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Macchia","sequence":"additional","affiliation":[{"name":"Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Panduri","sequence":"additional","affiliation":[{"name":"Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Dini","sequence":"additional","affiliation":[{"name":"Wound Healing research Unit, Department of Dermatology, University of Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5130","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000453728.12032.6f"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0634"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2003.11615.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12151"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12156"},{"issue":"5","key":"B6","first-page":"259","volume":"85","author":"Plotner A.N.","year":"2010","journal-title":"Cutis"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"issue":"1","key":"B8","first-page":"5","volume-title":"Wound Repair Regen","volume":"8","author":"Bailey A.","year":"2000"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000414705.56138.65"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3109\/2000656X.2011.633392"},{"issue":"9","key":"B11","first-page":"245","volume":"20","author":"Bertone M.","year":"2008","journal-title":"Wounds"},{"issue":"9","key":"B12","first-page":"258","volume":"20","author":"Romanelli M","year":"2008","journal-title":"Wounds"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.7.369"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31245"},{"key":"B16","volume-title":"Poster at 11th Annual Wound Healing Science and Industry","author":"Wieland M.","year":"2010"}],"container-title":["Journal of Wound Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/pdf\/10.12968\/jowc.2015.24.11.543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T15:42:00Z","timestamp":1653406920000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.magonlinelibrary.com\/doi\/10.12968\/jowc.2015.24.11.543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,2]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11,2]]}},"alternative-id":["10.12968\/jowc.2015.24.11.543"],"URL":"https:\/\/doi.org\/10.12968\/jowc.2015.24.11.543","relation":{},"ISSN":["0969-0700","2052-2916"],"issn-type":[{"value":"0969-0700","type":"print"},{"value":"2052-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,2]]}}}